University Of Pittsburgh

This study looks at using radiofrequency ablation (RFA), a heat-based treatment, to control lung tumors in 72 people with early-stage lung cancer or cancer that has spread to the lungs but who cannot undergo surgery. The goal is to see if RFA can improve survival, slow tumor grow…

This study looks at 1,236 young, active people aged 14-25 who are at high risk for re-injuring their ACL after surgery. It compares two common graft types (bone-patellar-tendon-bone and quadriceps tendon) and tests whether adding an extra stabilizing procedure (lateral extra-arti…

This study tests a non-surgical way to collect sperm from men with a condition called azoospermia, where no sperm is found in the semen. Using ultrasound guidance, doctors flush and aspirate fluid from a part of the testicle called the rete testis. The goal is to safely retrieve …

This study tests whether giving people with schizophrenia or schizoaffective disorder simple time- and event-based cues can improve their memory for taking medication. About 104 adults aged 18-60 will be randomly assigned to receive the cue-based help or standard care. The goal i…

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to teens aged 12-18 who experience depression and online bullying. The goal is to see if using the chatbot reduces stress and improves safety online. About 75 marginalized you…

This study looks at whether letting people put weight on their hip right after surgery (instead of waiting weeks) helps them recover faster and feel better. About 80 people who had hip arthroscopy for a torn labrum and hip impingement will be followed. Researchers will measure pa…

This study tests a video game designed to teach self-advocacy skills to women with advanced cancer. The game lets players make decisions for characters facing similar challenges, helping them learn to communicate better with doctors and manage symptoms. The goal is to improve qua…

This study tests whether a smartphone-based mindfulness training program can help stressed adults aged 45 and older lower their blood pressure and feel less strain. About 106 participants will either use the app for four weeks or continue their normal routine. Researchers will tr…

This study tests whether adding a computer-based cognitive training program to standard esketamine treatment can improve depression symptoms more than esketamine alone. Researchers will enroll 40 adults aged 18-80 who are already receiving esketamine at a clinic. The goal is to s…

This study looks at whether a remote training program can help rehabilitation professionals become better at teaching manual wheelchair skills. About 235 clinicians will be split into three groups: one gets the remote training with feedback, another does self-study online, and a …

This study tests a program called PIC-TRFS to help patients aged 50 and older recover at home after a stay in the intensive care unit (ICU). The program includes health management, rehabilitation, social support, and care coordination through telehealth. Researchers will compare …

This study aims to understand how the brain's temporal lobe helps process sound. Researchers will use EEG recordings from 10 people aged 13-25 who have had surgery to remove a brain lesion in a key hearing area. The goal is to build a computer model of how the brain responds to s…

This study involves about 3,650 adults starting medication for opioid use disorder at 20 treatment centers. Participants will use a digital tool to track their symptoms and share results with their providers. The goal is to see if this approach helps people stay in treatment long…

This study looks at ways to help people in rural Pennsylvania become more physically active. It includes 880 adults who are overweight, have type 2 diabetes, or are not active. Participants will report their activity levels and wear a device to track movement.

This study looks at the best ways to help patients in the intensive care unit (ICU) come off a breathing tube. It compares different training methods for healthcare workers and two types of oxygen therapy after the tube is removed. Over 13,000 adults on breathing machines for mor…

This study aims to see if the inner shape (concave or convex) of a full-arch dental bridge affects bone loss around the supporting implants. Researchers will measure the bridge's shape and check bone levels, probing depth, and bleeding in 50 adults who have had such a bridge for …

This study compares two different exercise tests used after a concussion in teens aged 14-17. The goal is to see which test better measures symptoms like headache and dizziness, as well as heart rate changes. Participants will do one test within 14 days of their injury. This is a…

This study looks at whether a pharmacist's review that includes genetic test results can help employees manage their medications better and lower healthcare costs. About 600 adults from Pitt/UPMC employee health programs who already had genetic testing will take part. Half will g…

This study tests a training program for doctors and nurses who care for pregnant women. The goal is to help them use proven medications for opioid use disorder more often. Researchers will track how many patients receive treatment and look at health outcomes for mothers and babie…

This study looks at whether wearable fitness trackers can help doctors spot early signs of trouble in people recovering from bladder removal surgery. About 50 participants will wear a Fitbit and answer daily questions on their phone for two weeks before surgery and 30 days after …