University Of Nebraska

This study is for men with prostate cancer that has spread to pelvic lymph nodes visible only on a special PET scan. It compares standard hormone therapy plus radiation to a stronger combination that includes abiraterone and prednisone. The goal is to see if the stronger treatmen…

This study tests a new way to give radiation for prostate cancer that has not spread. It combines two types of radiation: one placed directly into the prostate and another aimed at the prostate and nearby lymph nodes from outside the body. The goal is to see if this approach is s…

This study tests whether using a special PET scan (PSMA-PET) to guide radiation can reduce side effects while still controlling prostate cancer that has returned after surgery. About 54 men will receive a lower dose of radiation to the pelvis plus a higher dose to the exact spots…

This study looks at whether a lower dose of a common transplant drug can help older adults (60+) feel better after a stem cell transplant for blood cancers. The goal is to prevent graft-versus-host disease while improving quality of life. About 126 participants will receive eithe…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a type of brain cancer) has come back after standard treatment. The drugs are a low, continuous dose of temozolomide (a chemotherapy pill) plus abexinostat (an experimental drug). The main…

This study compares two ways to stop metastatic brain tumors from coming back after surgery. One group gets a chemotherapy wafer (GLIADEL) placed in the brain during tumor removal, while the other gets radiation within six weeks after surgery. About 100 adults with up to four bra…

This early study tests whether tamoxifen, a drug used for breast cancer, can shrink or stabilize pancreatic cysts that may turn into cancer. Up to 15 women with these cysts who are not having surgery right away will take tamoxifen daily for up to 24 weeks. The main goal is to see…

This study explores whether measuring pulse arrival time in arms and legs can detect peripheral artery disease (PAD), a condition where leg arteries narrow. Researchers will compare this new method to the standard ankle-brachial index test in 40 adults with or without PAD. Partic…

This study aims to increase colorectal cancer screening among African Americans, who face higher rates of this cancer. Researchers will provide 1,200 participants aged 45-75 with free take-home test kits and educational materials. Some participants will also see social media ads …

This study tests whether taking MitoQ for six months can improve walking ability and reduce leg pain in people with peripheral artery disease. Researchers will measure walking distance on a treadmill and during a 6-minute walk, as well as daily activity and quality of life. The s…

This study tests whether a single dose of the drug diroximel fumarate (Vumerity) can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to poor blood flow. Researchers will give 20 participants …

This study looks at whether meeting with a coach—either in person or by video—helps adults with a certain type of heart failure (HFpEF) exercise more regularly. 300 participants will be placed into one of three groups for 18 months: usual care, in-person coaching, or video coachi…

This study tests whether a spinal cord stimulator can reduce leg pain and improve quality of life in people with type 2 diabetes, painful nerve damage, and peripheral artery disease. Fifteen adults who already have a spinal cord stimulator will receive two weeks of active stimula…

This study tests whether escitalopram, a common antidepressant, can improve thinking and memory problems in people with a type of brain cancer called glioma. About 20 newly diagnosed patients will take the drug for 17 weeks while researchers measure changes in cognition, mood, an…

This study tests whether a special recovery plan (ERAS) helps people who have breast cancer surgery feel better with less pain and fewer opioid painkillers. About 260 adults with early-stage breast cancer will be randomly assigned to either the ERAS plan or standard care. Researc…

This study tests if using heat packs on the legs at home can help older adults (ages 50-90) with long COVID feel better and move more easily. Researchers will measure walking distance, physical function, and blood vessel health. The goal is to find a simple, safe way to improve d…

This study tests a training program that teaches caregivers of adolescents with profound autism how to use picture-based activity schedules. The goal is to help teens engage in activities on their own for short periods, giving caregivers time for other tasks. The study involves 3…

This study tests whether a daily nasal spray of oxytocin, a natural hormone, can lower stress and improve quality of life in female family caregivers of people with dementia. About 32 women aged 50 and older who provide unpaid care will receive either a low dose, a higher dose, o…

This study explores whether a non-invasive technique called repetitive transcranial magnetic stimulation (rTMS) can improve memory in healthy young and older adults, as well as in people with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's d…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study looks at whether LASIK or other corrective eye surgeries change the results of a common eye scan called OCT, which is used to monitor conditions like glaucoma. About 33 people who are planning to have refractive surgery will have their eyes scanned before and after the…

This study looks at whether a tailored exercise program can slow down the aging process in people aged 50 and older who have survived blood cancers like leukemia or lymphoma. Researchers want to find out how much and what type of exercise is needed to make a difference. The goal …

This study is following 1,250 people who are at higher risk for pancreas cancer, such as those with new diabetes, pancreas cysts, or a family history. Researchers will collect blood samples and health information over time to find early warning signs of the disease. The goal is t…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at how deep brain stimulation (DBS) affects attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive facial expressions. Researchers will use eye-tracking and computer tasks to compare participants before and after DBS surgery…

This study looks at whether six weeks of group therapy can change the gut microbiome in women experiencing chronic stress. Participants will fill out stress questionnaires and mail in stool samples before and after the therapy sessions. The goal is to understand the link between …

This study is testing a new app called Family Room to see if it helps family caregivers of ICU patients feel more involved, satisfied, and less stressed. About 100 caregivers will use the app or receive standard care, and their well-being will be tracked through surveys. The goal…

This study looks at how gum inflammation affects the body's healing response after a tooth is pulled. Researchers will measure signs of inflammation before extraction and take small tissue samples right after and two weeks later. 25 adults needing a back tooth removed will partic…

This study looks at whether a passive leg-paddling motion (LEAP therapy) during 2.5 hours of sitting can improve blood flow and walking ability in people with peripheral artery disease (PAD) and in healthy older adults. About 24 participants will each try both sitting with LEAP t…

This study looks at how brain tumors affect areas of the brain that control movement, sensation, and speech. Researchers will use special scans before, during, and after surgery to see how the brain reorganizes itself. The goal is to better understand brain plasticity and improve…

This study looks at how well the mouth heals after a tooth extraction in younger (14-18) and older (50-80) adults. Half of the participants will get a treatment made from their own blood, called platelet-rich fibrinogen, placed in the extraction site. Researchers will compare hea…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how using a 3D-printed prosthetic hand changes brain activity in children born with missing fingers, hands, or arms. Researchers will use a special brain scanner to measure brain responses while children perform tasks with the prosthetic. The goal is to learn …