University Of Nebraska

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited condition that causes lifelong skin, brain, and eye problems due to harmful fat buildup. The goal was to see if the drug is safe and can reduce these toxic substances. Partic…

This early-phase trial tested a drug called ONC-201 in 20 people with acute myeloid leukemia or myelodysplastic syndrome who had recently received a stem cell transplant. The goal was to see if taking ONC-201 weekly for a year could help prevent the cancer from coming back. The s…

This study compared two collagen-based wound dressings (one from pigs, one from cows) placed in tooth extraction sites after bone grafting. Nineteen non-smoking adults aged 19-65 who needed a premolar or front tooth extraction took part. The main goal was to see how each dressing…

This study tested a personalized approach to treating acute myeloid leukemia (AML) in adults aged 60 and older. Instead of a one-size-fits-all plan, doctors used genetic tests and a health assessment to choose either standard intensive chemo or a gentler therapy. The goal was to …

This study tested a treatment plan for people with early-stage HER2-positive breast cancer. After surgery, they received two chemotherapy drugs (cyclophosphamide and paclitaxel) plus a targeted therapy (trastuzumab). The goal was to see if this combination is safe and helps stop …

This study tested a program called PARITY that gives pregnant Black women community-based doula support, links to resources, and a mobile app with positive messages and wellness tips. The goal was to see if the program is practical and helpful for managing blood pressure and prom…

This early-phase study tested whether a drug called Leukine (sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week. Researchers monitored side effects, immune system changes, and movement …

This study checked if a simple finger stick blood test can correctly tell if a woman is pregnant. Researchers tested 30 women who already knew they were pregnant. The goal was to see if this quick, easy method works as well as standard lab tests.

This study tested a low-cost, portable exercise program to help people with non-small cell lung cancer manage severe tiredness after surgery. 235 adults took part. The program aimed to reduce fatigue and improve quality of life by teaching patients how to self-manage their energy…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help adults with sickle cell disease feel less pain during a pain crisis and leave the hospital sooner. Eight adults with uncomplicated sickle cell pain crises received 1 to…

This pilot study tested whether combining media literacy education, text message support, and financial incentives helps young adults (ages 19-29) quit vaping. Forty participants who wanted to quit were enrolled. The study measured engagement and vaping abstinence using saliva te…

This small early study tested a new way to help people with scleroderma who have trouble opening their mouth (microstomia). Doctors used a laser to deliver a natural enzyme called hyaluronidase into the skin around the mouth. The goal was to loosen tight tissue, making it easier …

This study tested whether a robotic baby harp seal named Paro could help children aged 5 to 18 feel less anxious and more motivated during physical or occupational therapy in the hospital. 25 children took part, and researchers measured pain, mood, and how much they enjoyed thera…

This study tested a breathing technique called Holotropic Breathwork to help people recover from addiction. 25 adults in residential treatment or living in the community took part. The goal was to see if the practice is safe, acceptable, and might reduce substance use and improve…

This study looked at how stem cell transplants affect thinking, memory, and daily life in adults aged 60 to 85. Researchers measured cognitive function, physical ability, and quality of life at several points after transplant. The goal was to understand which factors, including g…

This study looked at whether virtual reality can help stroke survivors who have uneven walking patterns. 42 adults who had a stroke at least 3 months ago participated. They used virtual reality to learn a new walking task, and researchers measured how their step length and timing…

This study looked at whether a free mobile app called BounceBack Now can help people with post-traumatic stress disorder (PTSD) in a primary care setting. Researchers worked with 29 adults, including patients and healthcare providers, to see if the app was easy to use and helpful…

This study tested a new screening tool that lets women choose which health topics to discuss before pregnancy, aiming to make preconception care easier in busy family clinics. Researchers compared two versions of the tool in 286 women of childbearing age to see which one better i…

This early-phase study looked at whether the drug Leukine (sargramostim) can help identify biological markers (biomarkers) in people with Parkinson's disease. Eleven participants received the drug for 48 weeks, and researchers monitored safety, immune cell changes, and movement s…

This study looked at a new blood test to measure beta cell death in people with cystic fibrosis (CF). Beta cells make insulin, and their death can lead to diabetes. Researchers compared levels of a specific DNA marker in 40 participants with CF and healthy controls to see if it c…

This study tested a new exercise program using visual feedback to help people load their knee properly after ACL surgery. The goal was to see if this could prevent knee arthritis, which often develops within 15 years after an ACL injury. 34 participants were followed for 6 months…