University Of Bern

This study tests a new type of dental bridge called the T-bridge, which uses just one implant to replace three missing back teeth. About 50 adults with a gap of 21-24 mm will get this bridge made of strong ceramic. Researchers will check how well the implant and bridge hold up ov…

This study tests whether a collagen matrix can help regrow bone and gum tissue damaged by severe gum disease, compared to a standard bone-graft material. About 80 adults with deep gum pockets will receive one of the two treatments during surgery. The goal is to see which material…

This study is testing whether a special chewing gum containing galactooligosaccharides (GOS) can help overweight adults lower their body mass index (BMI) and improve their metabolism. Researchers will also look at how the gum affects bacteria in the mouth and gut. The study invol…

This study tests whether adding platelet-rich fibrin (PRF) — a concentrate from your own blood — to standard implant surgery improves bone healing around infected implants. Forty adults with peri-implantitis will receive either surgery plus PRF or surgery alone. After 12 months, …

This study tests whether a new collagen matrix can replace the standard gum graft taken from the roof of the mouth to treat receding gums. Sixty adults who had braces and now have gum recession will receive either the collagen material or the traditional graft. The goal is to see…

This study tests whether adding a weekly medicine called tirzepatide to standard insulin therapy helps adults with type 1 diabetes control their blood sugar better. About 42 people aged 18-65 who already use an automated insulin pump will take part. The goal is to see if the drug…

This early study tests a new smartphone-based system that automatically adjusts insulin delivery for adults with type 1 diabetes. Six participants will use the system for a short time under close supervision. The goal is to see if the technology works reliably and safely before l…

This study tests whether a modified ketogenic (low-carb, high-fat) diet can help people with alcohol use disorder reduce their drinking. Fifty adults who meet the criteria will follow the diet and be monitored for several weeks. Researchers will measure diet adherence, blood keto…

This study looks at 100 adults who need a lower first molar removed and replaced with a dental implant. The implant is placed 12-16 weeks after extraction, and then a crown is attached either right away or 4 weeks later. Researchers want to see if immediate or early loading leads…

This study tests a one-hour online program called UKADO for people waiting to start face-to-face therapy for anxiety or depression. About 312 adults will try different versions of the program to see which works best. The goal is to find a way to help people feel better while they…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests whether adding antidepressant medication (fluoxetine or sertraline) to the Friendship Bench talk therapy helps adults with moderate to severe depression more than talk therapy alone. About 296 adults in Zimbabwe will take part. The goal is to see if the combinati…

This study tests whether applying a cross-linked hyaluronic acid gel during root-end surgery helps gums heal faster and lowers pain. About 46 adults with a tooth infection that didn't resolve after standard root canal treatment will take part. Half will get the gel during surgery…

This study follows 3,000 childhood cancer survivors in Switzerland to understand long-term health problems caused by past cancer treatments. Researchers collect data from check-ups, lab tests, and questionnaires. The goal is to learn more about late effects so doctors can better …

This study looks at people who have ongoing health problems after getting the COVID-19 vaccine, such as fatigue, heart issues, and brain fog. Researchers want to understand what causes these symptoms by tracking how they change over time and checking blood markers. The goal is to…

This study follows 250 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to find out how often the disease returns and which tests best predict that return. Participants will have regular check-ups and tests every six months for two…

This study tests whether sensors inside a car can tell if a driver is impaired by cannabis. Forty-five healthy adults who regularly use cannabis will drive on a closed track after consuming cannabis or nothing. Researchers will use data from the car, cameras, and body sensors to …

This study is building a national registry for people of any age living in Switzerland who have a rare disease or are strongly suspected of having one. The goal is to collect information like diagnosis, genetic details, and disease history to help researchers and doctors better u…

This study looks at how everyday physical activities (like walking to the bus) affect energy and mood in people with major depression. Researchers will use activity trackers and daily diaries to collect real-time data from 180 participants. The goal is to design personalized trea…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can change how the brain processes information. Healthy adults aged 20-40 and 60-80 will do computer tasks while receiving either real or placebo stimulation, and their brain activity will be me…

This study is building a national database of people with cerebral palsy (CP) in Switzerland. Researchers will collect information on diagnosis, treatments, and daily life from up to 15,000 participants. The goal is to monitor health trends, support research, and improve care and…

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and surveys to learn more about these problems and how to better diagnose and treat them. N…

This study looks at how the brain works differently in people who have attempted suicide versus those who have only thought about it. Researchers will also compare them to other psychiatric patients and healthy volunteers. Participants complete a one-time thinking and attention t…

This study is a registry that collects health information from people in Switzerland who have neuromuscular disorders like SMA, Duchenne, and Becker muscular dystrophy. The goal is to track their health over time to help improve treatments and care. Up to 2000 children and adults…

This study looks at how a short therapy program called ASSIP affects the brain and thinking of people who have attempted suicide. About 156 adults who have had at least one suicide attempt will be randomly assigned to either ASSIP or standard care. Researchers will measure change…

This study is a national registry that collects health information from people in Switzerland who have Primary Ciliary Dyskinesia (PCD), a rare lung condition. Researchers will track symptoms, lung function, treatments, and test results over time. The goal is to better understand…

This study compares two surgical techniques to build up gum tissue where a tooth is missing before placing a dental bridge. One method uses a piece of the patient's own connective tissue, the other uses a collagen material. Researchers will measure volume changes and ask about pa…

This study follows 1000 people with Primary Ciliary Dyskinesia (PCD), a rare lung condition, to track their ear, nose, and throat symptoms over two years. Researchers will collect information during regular check-ups to learn how these symptoms change over time. The goal is to be…

This study follows people with primary ciliary dyskinesia (PCD) to learn more about their symptoms, treatments, and daily life. Anyone with suspected or confirmed PCD can join from anywhere in the world. Participants fill out questionnaires when they start and then once a year, w…

This study looks at whether the chemicals we breathe out change during the day in people with and without diabetes. Researchers will compare breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to understand normal daily pattern…

This study tests a program to help doctors reduce or stop unnecessary acid reflux medications (PPIs) in 400 adults who have been taking them daily for at least 8 weeks. The goal is to see if the program is safe and effective compared to usual care. Participants will be followed f…

This study looks at why breast and colorectal cancer survivors may be at higher risk for a common liver condition called MASLD (fatty liver disease). Researchers will use painless ultrasound and MRI scans, along with blood tests, to detect liver damage early. The goal is to impro…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…