Could a gel make root canal surgery less painful?

NCT ID NCT07501585

Symptom relief Sponsor: University of Bern Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether applying a special gel (cross-linked hyaluronic acid) during root-end surgery helps the gums heal faster and reduces pain afterward. About 46 adults with a tooth infection that didn't heal after standard root canal treatment will take part. Half will get the gel during surgery, and half will have surgery alone, with follow-up for one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: cross-linked hyaluronic acid
What this could lead to: If it works, this could mean faster healing and less pain after root-end surgery for people with persistent tooth infections.
What could go wrong: This is a small early-stage trial with only 46 participants, so results may not apply to everyone. The benefit over standard surgery alone may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 46 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent * ≥18 years of age * Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment * Full mouth plaque score (FMPS) and bleeding score (BoP) \< or 20% * Periapical lesion \< or 10 mm * Four-wall bone defect morphology Exclusion Criteria: * Smokers of more than 10 cigarettes a day * Allergy to hyaluronic acid * Pregnancy or lactation * Uncontrolled Diabetes * Untreated periodontal conditions * Any conditions associated with poor compliance or failure to maintain good oral hygiene * Acute infections lesions in areas intended for surgery * Chemotherapy and radiotherapy treatment

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periapical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a gel make root canal surgery less painful?

What the study statuses mean