Peking University First Hospital

This study tests a new treatment for a rare cancer of the upper urinary tract that has spread into the kidney or nearby lymph nodes. The treatment combines a targeted drug (disitamab vedotin) with radiation therapy, and is compared to standard chemotherapy. About 192 adults who c…

This study tests whether a supplement called TUDCA, taken by breastfeeding mothers with a fatty liver condition, can improve the health of both mother and baby. Researchers will enroll 80 mother-infant pairs and randomly give the mother either TUDCA or a placebo. The goal is to s…

This study tests whether adding darolutamide to standard hormone therapy after prostate removal can delay or prevent cancer recurrence in high-risk patients. About 40 men will receive the drug combination for 2 years, with regular PSA tests and scans to monitor outcomes. The goal…

This study tests a treatment plan for a rare cancer of the kidney and ureter that avoids removing the whole kidney. Patients first have a less invasive surgery to remove the tumor, then receive targeted drugs and radiation. The goal is to see if this approach can prevent the canc…

This trial tests if islet cells made from stem cells can safely help people with diabetes. About 30 adults who have had diabetes for over 5 years and use insulin will receive an infusion of these cells. The goal is to see if the cells can improve blood sugar control and reduce th…

This study will follow 1000 men with suspected prostate cancer to see if repeated MRI scans can better detect dangerous cancers and reduce the need for biopsies. Participants will have MRI scans over time, and doctors will track how the images change. The goal is to make prostate…

This study tests a new type of PET/CT scan that uses a special tracer to find BCMA, a protein on myeloma cells. The goal is to see if this scan can accurately detect active myeloma lesions compared to biopsy. About 300 people with suspected or known multiple myeloma will take par…

This study tests whether giving older patients (65-90) a combination of two medicines (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) around the time of surgery can prevent confusion, memory loss, and other thinking problems that often occur afte…

This study looks at whether giving older adults (65-90) a combination of two drugs (dexmedetomidine and esketamine) along with a gentle brain stimulation technique (tDCS) before non-cardiac surgery can prevent long-term memory and thinking problems. About 1160 participants with m…

This study tests whether a low dose of esketamine, a common anesthetic, can prevent confusion and memory problems in older adults after non-cardiac surgery. About 120 patients aged 65-90 will receive one of three esketamine doses or a placebo during and after surgery. The goal is…

This study tests whether taking tamsulosin (a drug that relaxes the prostate) before and after a prostate biopsy can prevent serious urination problems. About 1,844 men will either take the drug or receive no preventive medication. The goal is to see if the drug reduces the need …

This study tests whether giving a combination of two drugs, dexmedetomidine and esketamine, before and after spinal surgery can lower the chance of moderate-to-severe pain in the first three days after the operation. About 274 adults aged 40 to 79 having spine surgery will take p…

This study tests whether giving two drugs together during spinal surgery can lower the chance of long-term pain. About 274 adults aged 40-79 having spine surgery will receive either the drug combo or a placebo. The goal is to see if fewer people have pain 3 to 6 months after surg…

This study looks at 50 adults with AL amyloidosis, a rare disease where abnormal proteins damage organs. After initial chemotherapy, some patients still have tiny traces of the disease (called MRD). The study will check if a stem cell transplant can remove those traces and improv…

This study will follow about 2,500 adults with liver cirrhosis to learn who develops dangerous blood clots in the liver's main vein. Researchers will review past cases and track new patients for two years to build a prediction tool, measure how clots affect survival, and see if b…

This study looks at how deep anesthesia affects thinking and memory recovery in older adults (65+) after non-heart surgery. Researchers will compare two different anesthesia depths using a fixed drug ratio. The goal is to see if one depth leads to fewer thinking problems after su…