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Could a common anesthetic prevent post-surgery brain fog in seniors?

NCT ID NCT07523334

Symptom relief Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a drug called esketamine can help prevent confusion and memory problems that sometimes happen after surgery in older adults. The trial will involve 120 people aged 65 to 90 who are having major non-cardiac surgery. Researchers will compare three different doses of esketamine to find the best balance between protecting the brain and avoiding side effects like feeling detached.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Esketamine (a type of ketamine anesthetic)
What this could lead to
If it works, this could point toward a way to prevent or reduce confusion and memory problems after surgery in older adults.
What could go wrong
This is a small, early pilot trial with only 120 people, so results may not apply to everyone. Esketamine can cause dissociative symptoms (feeling detached) and other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged \>=65 but \<= 90 years; 2. Scheduled to undergo non-cardiac surgery with an expected duration of \>= 2 hours under general anesthesia; 3. Requiring patient-controlled intravenous analgesia (PCIA) after surgery. Exclusion Criteria: 1. Unable to communicate preoperatively due to visual or auditory impairment, language barrier, or severe dementia; 2. Comorbid with schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis; 3. Traumatic brain injury or neurosurgery; 4. Severe hepatic dysfunction (Child-Pugh Class C), severe renal dysfunction (receiving dialysis preoperatively), or American Society of Anesthesiologists physical status classification \>= Ⅳ; 5. Expected admission to the Intensive Care Unit with endotracheal intubation after surgery; 6. Anaphylaxis to esketamine; 7. Participation in other clinical studies, or any other conditions that are considered unsuitable to be involved in the study.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delayed neurocognitive recovery Elderly Esketamine Noncardiac surgery Postoperative delirium

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034, China

  • Tianjin Medical University General Hospital

    Tanjing, Tianjing, 300052, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.