POSTOPERATIVE DELIRIUM

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery. About 80 adults aged 60 and older having valve or bypass surgery will take either the drug or a placebo for three nights after surgery. Researchers will check f…

This study compares two sedative drugs, dexmedetomidine and midazolam, to see which one is better at preventing confusion (delirium) after heart bypass surgery. About 60 adults having elective bypass surgery will take part. The goal is to find out if one drug leads to fewer cases…

This study tests a digital sleep improvement program (a mobile app and a wrist tracker) in 50 older adults (65+) who are having hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surgery. Participants must have mild i…

This study tests whether relaxation techniques like virtual reality and binaural beats before heart surgery can lower stress and prevent mental problems like confusion or memory loss after the operation. About 125 adults having planned heart surgery will take part. The goal is to…

This study watches 270 elderly patients (over 65) having non-cardiac surgery to see how often they develop postoperative delirium — sudden confusion or disorientation. Researchers will track risk factors like age, frailty, and health conditions, and measure outcomes like hospital…

This study is looking at whether certain proteins in the blood can help predict if older adults with diabetes will become confused after surgery. Researchers will measure these proteins before surgery and then check patients for confusion for three days after. The goal is to find…

This study looks at whether feeling distressed before surgery is linked to confusion (delirium), pain, and longer hospital stays after major orthopedic surgery in people aged 65 and older. Researchers will measure distress before surgery and track recovery outcomes in 150 partici…

This study looks at whether a score based on routine blood tests (the Naples Prognostic Score) can predict postoperative delirium—sudden confusion—in older adults after hip fracture surgery. Researchers will enroll 168 patients aged 60 and older and check for delirium daily using…

This study looks at whether simple blood tests can predict confusion after anesthesia in children having circumcision. Researchers will check inflammation markers in the blood of 140 children aged 2-12 before surgery and see if those with higher levels are more likely to be confu…

This study is for 500 adults having elective heart surgery with a heart-lung machine. Researchers will monitor each patient's personal blood pressure limits using special brain sensors. The goal is to see if keeping blood pressure within those limits reduces the risk of brain pro…