POSTOPERATIVE DELIRIUM

This study tests whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in patients aged 65 and older. About 4,000 participants will be randomly assigned to either rout…

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery in adults aged 60 and older. About 80 participants will receive either the drug or a placebo for three nights after surgery. Researchers will track delirium symp…

This study tests whether doing simple, home-based brain exercises for a few weeks before heart surgery can help prevent postoperative delirium (sudden confusion) and long-term memory problems. Researchers will enroll 100 adults scheduled for elective heart surgery. Half will do t…

This study tests whether relaxing before heart surgery using virtual reality, nature sounds, or binaural beats can reduce stress and prevent postoperative confusion (delirium) and memory decline. About 125 adults having elective heart surgery will be randomly assigned to one of t…

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

This observational study is testing whether non-invasive monitors that track brain electrical activity and oxygen levels can help determine the best blood pressure to maintain during major non-cardiac surgery in people over 60. The goal is to see if these monitors can reliably gu…

This study looks at whether the Naples Prognostic Score, a combination of blood markers, can predict postoperative delirium in elderly patients having hip fracture surgery. Researchers will enroll 168 people aged 60 and older and check for delirium daily using a standard assessme…

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study watches 270 patients aged 65 and older who are having non-cardiac surgery to see how many develop postoperative delirium—sudden confusion or disorientation after the procedure. Researchers will track risk factors like age, frailty, and health conditions, and follow out…

This study looks at whether feeling distressed before surgery is linked to delirium, pain, and longer hospital stays in elderly patients having major orthopedic surgery. Researchers will measure distress levels before surgery and track outcomes afterward. The goal is to better un…

This study looks at how two different anesthesia methods—one given through a vein and one inhaled as a gas—affect thinking and recovery after sleeve gastrectomy (weight-loss surgery). About 60 adults having this surgery for the first time will take part. Researchers will measure …

This study follows 1,500 adults having planned heart surgery to learn why some become confused or delirious afterward. Researchers will look at factors before surgery that raise the risk, and track patients over time to see how delirium affects their recovery and long-term health…

This study looks at 100,000 adults having surgery to find out if one type of anesthesia (propofol or sevoflurane) is better at preventing postoperative delirium—a state of confusion that can happen after surgery. Researchers will track who develops delirium in the first 5 days af…

This study is looking for a way to predict which older adults with diabetes might become confused after surgery. Researchers will measure specific proteins in the blood before surgery and see if they are linked to confusion in the days after. The goal is to better understand and …

This study is looking at whether simple blood tests can help predict which children might become confused or agitated after waking up from anesthesia for circumcision. Researchers will check inflammation levels in the blood before surgery and watch for signs of delirium in the re…