Children's Hospital Of Fudan University

This study follows five patients with beta-thalassemia for two years after they received an experimental gene therapy called CS-101. The goal is to monitor the long-term safety of the treatment and see if patients remain free from needing blood transfusions. Researchers will trac…

This study is testing whether using two types of medications together works better than using just one to control Crohn's disease in children and teenagers. Researchers will compare how well the treatments reduce symptoms and gut inflammation over about a year. The goal is to fin…

This study is testing a new two-step treatment for children with a rare, severe genetic condition that causes both type 1 diabetes and a weakened immune system. First, doctors transplant umbilical cord blood stem cells to try to rebuild the child's immune system. If that is succe…

This study is testing whether hydroxychloroquine, a medication used for malaria and autoimmune diseases, can help children with rare genetic lung disorders breathe easier. Researchers will compare children who receive the drug to those who don't to see if it improves oxygen level…

This study is testing whether a continuous blood filtering treatment helps children with severe bloodstream infections (sepsis) survive and recover better than standard care. Researchers will compare two groups of children to see if early use of this blood purification improves 2…

This 3-year study is testing a new remote therapy program called STAR, designed to help parents learn skills to support their toddlers with autism. The trial will compare the STAR program, delivered online, to standard community care. Researchers aim to see if this accessible, pa…

This study is testing whether dietary supplements called prebiotics and probiotics can help control appetite and weight gain in children with Prader-Willi syndrome, a rare genetic disorder that causes constant hunger and severe obesity. Sixty children will be divided into groups …

This study is looking back at past medical records to see if a treatment called gamma globulin helps children with severe infections. These children have a dangerous overreaction of their immune system, called an inflammatory storm, which can lead to organ failure. Researchers wi…

This study is testing whether a combination of traditional Chinese herbal medicine and small, shallow acupuncture needles can help slow down early puberty in girls. Researchers want to see if this approach can reduce early breast development and delay bone maturation compared to …

This study is testing whether a 12-week high-fiber diet can help protect the body's ability to produce insulin in children recently diagnosed with type 1 diabetes. Researchers will compare children who follow the special diet to those who receive usual care. They will measure ins…

This study is looking at a medication called dupilumab for children with a severe, hard-to-treat form of stomach and gut inflammation. It aims to see if the drug can help heal ulcers and reduce inflammation in kids who haven't responded well to other treatments. The researchers w…

This study is testing two different types of filters used in a blood-cleaning treatment for children with sepsis, a life-threatening response to infection. The goal is to see which filter is better at removing harmful inflammation-causing substances from the blood, which could he…

This study is testing whether a time-efficient exercise program called High-Intensity Interval Training (HIIT) can improve heart and metabolic health in children and teens who already show early warning signs. It will involve 336 participants aged 7-18 who have conditions like pr…

This small pilot study is testing a specific, lower dose of the blood thinner rivaroxaban in Chinese children who have developed a giant bulge (aneurysm) in their heart arteries after Kawasaki disease. The goal is to see if this dose is safe and effective at preventing dangerous …

This study aims to find out if a more comprehensive genetic test (whole genome sequencing) is better than a standard one (whole exome sequencing) at identifying the genetic causes of chronic diarrhea and intestinal problems in infants. Researchers will enroll 180 infants and rand…

This study is testing whether a faster genetic sequencing technology can improve how quickly doctors diagnose birth defects and genetic diseases in newborns. It will involve 2,000 babies in neonatal intensive care units who have unexplained health problems. The goal is to see if …

This study aims to see if measuring a substance in the blood called copeptin can help doctors quickly diagnose a water-balance disorder called central diabetes insipidus (CDI) in children after brain surgery. Researchers will track copeptin levels in 100 children in the intensive…

This study is testing a bundled care plan designed to prevent children from becoming dependent on mechanical ventilators (breathing machines). The plan involves carefully timed intensive rehabilitation, nutrition support, and procedures like tracheostomies. Researchers will compa…

This study is testing whether a special nurturing approach called 'developmental care' helps very small premature babies. Researchers want to see if this gentle care helps babies leave the hospital sooner and allows families to be more involved in their care. The study involves 4…

This study is testing a new program where nurses start conversations about palliative care early in a child's cancer treatment. It aims to see if these regular talks improve the child's quality of life, manage symptoms better, and reduce stress for family caregivers compared to s…

This study aims to understand how a powerful antibiotic moves through and works in the bodies of children with severe infections who are on life support. Researchers will observe 30 children already receiving this antibiotic as part of their standard hospital care. The goal is to…

This study aims to collect health information from 5,000 children in China who have severe infections like sepsis or pneumonia. Researchers will use this data to understand how common these illnesses are, how they affect children, and which treatments work best. The goal is to bu…

This study aims to understand how the antifungal drug caspofungin is processed by the bodies of critically ill children. Researchers will measure drug levels in the blood of 60 children in intensive care who are receiving the drug for severe fungal infections. The goal is to see …

This study is testing whether a specific planning tool helps nurses make better decisions when selecting intravenous (IV) devices for children in the hospital. Researchers will train nurses to use the tool and a decision guide, then track if it improves their knowledge and reduce…

This study aims to find out if a simple blood test taken before surgery can help predict the long-term outcome for infants with biliary atresia. Researchers will measure a protein called FGF19 in the blood of 200 children who have had surgery for this liver condition. The goal is…

This study aims to see if genetic testing can help doctors choose better treatments for babies who have seizures. Researchers will perform genetic tests on up to 2,000 babies in China who started having seizures before their first birthday. The goal is to learn if a baby's specif…

This project aims to sequence the genes of 100,000 newborns in China over five years. The goal is to build a large genetic database to understand how common certain inherited diseases are in newborns. This information will help create better standards for genetic testing and coun…

This study aims to look back and summarize the use of ECMO, a form of life support, for children in China over the past decade. Researchers will collect information from hospitals about 500 children who received this treatment to understand survival rates, treatment duration, and…

This study aims to create a large database and sample bank for newborns with serious brain conditions in China. It will collect medical information, blood, urine, and spinal fluid from up to 2,000 babies to help researchers better understand these conditions. The goal is to use t…

This study aims to understand how social behaviors and brain connections develop differently in infants who have a higher chance of developing autism. Researchers will follow 100 infants, some with an older sibling with autism and some without, from 3 months to 3 years old. They …

This study aims to better understand severe infections in children who are critically ill and admitted to pediatric intensive care units (PICUs) across China. Researchers will collect information from 2,000 patients over ten years to track what germs cause infections, how they ar…

This large, multi-hospital project aims to improve the safety and success of placing feeding tubes in children. It will review the latest medical evidence, update nurse training, and create standardized procedures to reduce errors. The goal is to ensure hospitalized children rece…

This study aims to better understand a rare form of chronic diarrhea in children called congenital diarrhea and enteropathy (CODE). Researchers will collect detailed health information from 60 children with CODE and use advanced lab tests to look for biological markers. The goal …

This study aims to understand how common seizures are in newborn babies in China and what factors might increase the risk. Researchers will monitor 1,400 newborns (0-28 days old) who have been diagnosed with seizures, using brain wave tests (EEG) and collecting health information…

This study looks back at medical records to understand what makes children in a pediatric intensive care unit (PICU) more likely to get or carry dangerous, drug-resistant bacteria called CRE. Researchers will analyze data from over 500 children hospitalized between 2018 and 2019.…