Amgen

This study tested a new medicine, ABP 938, against an existing treatment (Eylea) for wet age-related macular degeneration, a leading cause of vision loss in older adults. About 576 people aged 50 and older with active disease received injections of either drug into the eye. The m…

This early-phase study tested a drug called sotorasib (AMG 510) in 12 people of Chinese descent with advanced solid tumors that have a specific KRAS G12C mutation. The main goals were to check safety and how the drug moves through the body. While the drug aims to shrink tumors, t…

This study tested a new two-drug combination (anvumetostat and IDE397) in 53 adults with advanced solid tumors that lack a gene called MTAP. The goal was to find a safe dose and see if the drugs shrink tumors, especially in lung cancer. The trial is now complete, and results will…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who had low platelets from chemotherapy. The goal was to see if romiplostim could prevent dose delays or reductions. Results showed it helped maintain chemotherapy sc…

This study tested a new medicine called rocatinlimab, given as an injection, along with standard topical creams, in 746 adults with moderate-to-severe eczema (atopic dermatitis). The goal was to see if the combination could clear the skin and reduce itching better than creams alo…

This study looked at the safety of the drug sotorasib in 102 Chinese adults with a specific type of advanced lung cancer (KRAS G12C-mutated NSCLC) who had already tried other treatments. Researchers tracked side effects like liver problems, lung inflammation, and kidney issues. T…

This study tested whether teenagers and adults with moderate-to-severe eczema (atopic dermatitis) could successfully give themselves injections of the drug rocatinlimab at home using special devices. The main goal was to see how many full doses were self-administered correctly up…

This study tested a drug called bemarituzumab in 260 adults with solid tumors that have too much of a protein called FGFR2b. The main goals were to see if the drug is safe and if it can shrink tumors. Participants had cancers that stopped responding to standard treatments.

This study tested a new medicine called rocatinlimab for adults with moderate-to-severe eczema (atopic dermatitis). 769 people took part. The goal was to see if the drug could clear the skin and reduce itching better than a placebo over 24 weeks. Results showed meaningful improve…

This early-stage study tested a new drug called AMG 133 in 110 adults with obesity. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers tracked side effects and drug levels in the blood.

This early-phase study tested two drugs, tarlatamab and AMG 404, together in 23 adults with small cell lung cancer that had worsened after standard chemotherapy. The main goal was to check safety and find the right dose for future studies. While the treatment aims to control the …

This study tested a combination of three drugs (carfilzomib, pomalidomide, and dexamethasone) in 54 adults with multiple myeloma that had come back after initial treatment. The goal was to see how many patients responded to the treatment. Most participants had a significant reduc…

This study tested a new drug, ABP 206, to see if it works as well as the approved drug OPDIVO for people with advanced melanoma that has been removed by surgery. The trial involved 256 adults who had their melanoma completely removed within the last 12 weeks. The goal was to comp…

This study tested a monthly injection called erenumab in 620 adults with chronic migraine who also overused headache medications. The goal was to see if the drug could reduce how often they needed painkillers and lower their headache days. Results showed that more people on erenu…

This early-stage study tested a single injection of a new drug called AMG 133 (Maridebart Cafraglutide) in 20 Chinese adults who are overweight or have obesity. The main goal was to see how the drug moves through the body and to check for any safety issues. Participants were heal…

This study looked at how safe and effective OTEZLA is for people with psoriasis (skin plaques) or psoriatic arthritis when used in normal doctor visits. Over 1,000 adults who had not gotten enough relief from creams or other skin treatments took part. Researchers tracked side eff…

This study tested a combination of two drugs, sotorasib and panitumumab, in 160 adults with advanced colorectal cancer that has a specific KRAS G12C mutation and has not responded to prior treatments. The goal was to see if this combination helps keep the cancer from growing long…

This early-stage study tested a new drug called Tarlatamab in 41 men with a rare and aggressive form of prostate cancer (neuroendocrine prostate cancer). The main goal was to check the drug's safety and find the best dose. The drug works by helping the body's immune cells attack …

This early-phase study tested a new drug, AMG 305, in 37 adults with advanced solid tumors who had no other treatment options. The main goals were to check the drug's safety and find the best dose for future studies. Researchers monitored side effects and how the drug moved throu…

This study tested a drug called rocatinlimab in 532 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't get better with standard creams. The goal was to see if the drug could clear the skin and reduce itching. Participants received either the drug or a placebo for …

This study tested a new medicine called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe eczema (atopic dermatitis). The main goal was to see if the drug is safe and tolerable over 52 weeks. Participants had not responded well to standard creams or ointments. T…

This study looked at the safety of the drug Kyprolis (carfilzomib) in 101 Indian adults whose multiple myeloma had come back or stopped responding to treatment. Researchers tracked side effects and how long patients lived without their cancer getting worse. The goal was to confir…

This early-stage study tested a new medicine called AMG 890 in about 80 people with high levels of lipoprotein(a), a genetic risk factor for heart disease. The main goal was to check the drug's safety and how the body processes it. Participants received a single dose of the drug …

This study tested an investigational drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that was not well controlled by standard treatments. Participants received either daxdilimab or a placebo to see if the drug could reduce disease activity and…

This study followed about 500 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctors. Researchers tracked how well the drug controlled symptoms like joint pain and skin plaques over up to 100 weeks in real-world clinics. The goal w…

This study tested a new medicine called olpasiran in 281 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to see if olpasiran could safely lower lipop…

This study tested whether a gout medication (pegloticase) given every 4 weeks with methotrexate works as well as the standard every-2-week schedule for people with hard-to-control gout. About 262 adults with uncontrolled gout took part. The goal was to see if the less frequent do…

This study tested three different doses of a new drug, AMG 133, against a placebo in 592 adults with overweight or obesity. Some participants also had type 2 diabetes. The main goal was to see how much weight people lost after 52 weeks of treatment. The drug aims to help control …

This study tested a gout medication called KRYSTEXXA given every 4 weeks along with weekly methotrexate in 50 adults with severe gout that didn't respond to standard treatments. The goal was to see if this combination could lower uric acid levels and be safe. The results help gui…

This study looked at the long-term safety and effects of the drug apremilast in children aged 6 to 17 with moderate to severe plaque psoriasis. Participants who had already completed one year of treatment could continue taking the drug for up to 208 weeks (about 4 years). Researc…

This study looked at how safe and tolerable different lengths of treatment with teprotumumab are for adults with thyroid eye disease. 313 participants received the drug for varying durations to see if shorter treatment works as well and reduces side effects. The goal was to find …

This study tested a daily pill called apremilast in 203 Chinese adults with moderate to severe plaque psoriasis. Participants took either the drug or a placebo for 16 weeks. The main goal was to see if the drug could reduce psoriasis severity by at least 75% compared to no treatm…

This early-stage study tested the safety of blinatumomab in 6 Japanese adults newly diagnosed with a type of leukemia (B-ALL). The main goal was to see what side effects occurred. Participants received the drug through an IV after initial chemotherapy. Results help guide future r…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study looked at whether giving the gout medication pegloticase over a shorter time is safe and works well for people with uncontrolled gout who are also taking methotrexate. About 191 adults took part. The main goal was to check for infusion reactions, and a key measure was …

This study looked at how well the drug teprotumumab works for thyroid eye disease, a condition that can cause bulging eyes. It involved 5 people in China who received the drug. The main goal was to see if their eye bulging improved by at least 2 millimeters after treatment.

This study tested a daily pill called sotorasib in 42 adults with advanced lung cancer that has a specific genetic change (KRAS G12C) and has not been treated yet. The goal was to see if the drug shrinks tumors and how safe it is. Participants received either a 960 mg or 240 mg d…

This study tested whether evolocumab, a cholesterol-lowering drug, can reduce major heart problems like heart attacks and strokes in adults at high risk but who have never had one before. Over 12,000 participants aged 50-80 with high cholesterol took either evolocumab or a placeb…

This early-stage study tested a new drug called AMG 256 in 34 adults with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the best dose for future studies. The study is now complete, but it does not offer …

This study tested the safety of a drug called romosozumab (EVENITY) in 100 postmenopausal women in India who have osteoporosis and a high risk of breaking a bone. The main goal was to see what side effects occurred. The drug is already approved and aims to strengthen bones, but t…

This early-stage study tested a new drug called AMG 786 in 65 healthy adults and people with obesity. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or multiple doses and monitored for side effects. This is a first step to se…

This study tested whether the drug erenumab can prevent migraines in children aged 6 to 17 with chronic migraine (15+ headache days per month). About 284 participants received either the drug or a placebo for 3 months. The main goal was to see if the drug reduced the number of mo…

This study tested the drug erenumab in 512 adults with high-frequency episodic migraine (7 to 14 migraine days per month) who had already tried at least one other preventive treatment without success. The main goal was to see if erenumab could reduce the total hours of moderate-t…

This early-phase study looked at how AMG 133, an experimental drug, affects how quickly the stomach empties in people who are overweight or have obesity. Researchers gave the drug or a placebo to 57 adults and measured stomach emptying using a special marker. The goal was to unde…

This study tested a single dose of the drug olpasiran in 33 adults with normal kidney function or varying degrees of kidney impairment. The goal was to see how the body processes the drug and to check for safety. Results help doctors understand dosing for patients with kidney iss…

This study looked at how the drug avacopan is processed by the body in people with normal kidney function and in those with end-stage kidney disease who need dialysis. Thirteen adults took a single dose, and researchers measured drug levels in blood and dialysis fluid, as well as…

This study looked at whether rocatinlimab, a drug for moderate-to-severe eczema, changes how well vaccines work. About 221 adults with eczema received either the drug or a placebo, then got tetanus and meningitis vaccines. The goal was to see if their immune response was differen…

This study followed 187 melanoma patients treated with IMLYGIC, a virus-based therapy, to see if the virus spreads to close contacts or healthcare workers. Researchers also checked for long-term safety issues over 5 years. The goal was to understand real-world risks, not to test …

This study looked at nearly 40,000 people with a history of heart disease to measure their levels of lipoprotein(a), a type of fat in the blood that can increase heart risk. Researchers wanted to see how these levels vary among different groups of people and regions. The goal was…

This study tested a single dose of rocatinlimab in 20 healthy Chinese adults to see how the drug moves through the body and if it is safe. The drug is being developed for atopic dermatitis (eczema). No treatment was given—only observation of drug levels and side effects.

This study looked at how a single dose of the experimental drug AMG 133 is processed in the body of people with normal kidney function compared to those with various levels of kidney problems. It involved 44 overweight adults. The goal was to gather safety and drug-level informat…

This early-phase study looked at how rocatinlimab, a potential new treatment for moderate to severe eczema (atopic dermatitis), interacts with other common drugs. 21 adults with eczema took part. The goal was to measure drug levels in the blood and check for side effects, helping…

This study looked at how the drug olpasiran is processed in people with different levels of liver impairment (mild, moderate, or severe) compared to people with healthy livers. A total of 25 adults took a single dose of the drug. The goal was to understand how liver function affe…

This study looked at how the drug teprotumumab behaves in the body of healthy Chinese adults after a single intravenous dose. Twenty participants were enrolled to measure drug levels and check for side effects. The goal was to gather safety and dosing information, not to treat an…

This study looked at how the body absorbs rocatinlimab, an experimental drug for atopic dermatitis (eczema), when given as a single shot using an autoinjector versus a traditional vial and syringe. It involved 231 healthy adults aged 18 to 60. The goal was to see if the autoinjec…

This study looked at how the body processes a single dose of the drug AMG 133 in 36 adults with mild, moderate, or severe liver problems compared to those with healthy livers. The goal was to see if liver function changes drug levels and safety. Results will help doctors decide t…

This study looked at whether taking an anti-nausea medication (ondansetron) changes the amount of AMG 133 in the blood of people who are overweight or obese. 59 adults took AMG 133 alone or with the anti-nausea drug. The goal was to measure drug levels and check for side effects,…

This completed Phase 1 study checked whether olpasiran, an experimental drug, changes heart rhythm in 32 healthy adults aged 18 to 60. Participants received a single dose of olpasiran, a placebo, or a positive control in a crossover design. The main goal was to measure any effect…

This study looked at how the body processes rocatinlimab when given as a shot from a vial versus a prefilled syringe. It involved 240 healthy adults aged 18 to 65. The goal was to see if both methods work the same way, not to treat any disease.