Amgen

This study tested whether a drug called daxdilimab could reduce skin disease activity in adults with moderate-to-severe discoid lupus erythematosus, a condition causing scarring skin rashes. About 72 participants received either the drug or a placebo injection every four weeks fo…

This was a first-in-human study to test the safety and find the right dose of an experimental drug called AMG 794. It was for adults with advanced or metastatic cancers, like lung or ovarian cancer, that have a specific protein marker called claudin 6 (CLDN6). The trial was termi…

This study aimed to see if taking the drug HZN-825 for an additional 52 weeks was safe and effective for people with a severe form of scleroderma, a disease that hardens skin and can damage internal organs. It was an extension of a previous trial, enrolling 174 participants who h…

This early-stage study tested an experimental drug called AMG 420 in patients with multiple myeloma that had returned or stopped responding to at least three prior standard treatments. The main goals were to check the safety of two different dose levels and see if the drug showed…

This study tested several experimental drug combinations for men with advanced prostate cancer that had spread and stopped responding to standard hormone treatments. The trial aimed to find safe doses and see if these new approaches could help control the cancer. It was terminate…

This study aimed to evaluate the long-term safety and effectiveness of the drug efavaleukin alfa in people with moderate to severe ulcerative colitis. It was an extension study for 25 participants who had completed a previous 52-week trial. The main goal was to monitor side effec…

This was an early safety study of a new drug called AMG 199 for adults with advanced stomach, colon, or pancreatic cancers that have a specific marker called MUC17. The main goals were to find a safe dose and see how the body handles the drug. The treatment aims to guide the pati…

This study tested an experimental oral drug called HZN-825 to see if it could slow the progression of lung scarring in people with idiopathic pulmonary fibrosis (IPF). About 153 participants were randomly assigned to receive either the drug at one of two doses or a placebo for on…

This trial tested an investigational drug called HZN-825 in adults with a severe form of systemic sclerosis, a disease that causes skin thickening and can damage the lungs. About 300 participants received either the drug or a placebo for one year to see if it could improve lung f…

This early-stage study tested a new drug called AMG 701, both alone and combined with other medications, for adults with multiple myeloma that had returned or stopped responding to many prior treatments. The main goals were to find a safe and effective dose and to see how the bod…

This study tested a new drug called efavaleukin alfa in adults with moderate to severe ulcerative colitis, a chronic bowel disease. The main goal was to see if the drug could help patients achieve remission, meaning their symptoms and bowel inflammation went away. The trial was d…

This was an early safety study for a new drug called acapatamab, designed to help the body's own immune cells attack advanced prostate cancer. It involved 212 men whose cancer had spread and was no longer responding to standard hormone and chemotherapy treatments. The main goal w…

This early-stage study aimed to check the safety of a new drug called AMG 378 and see how the body absorbs and processes it. It involved 48 healthy adults who received either the drug or a placebo. The trial was terminated, meaning it was stopped early, and its main goal was to g…