Amgen

This study tests two drugs, inebilizumab and blinatumomab, in people with hard-to-treat lupus or rheumatoid arthritis. The goal is to see if they are safe and can control the disease. About 220 adults will take part. This is not a cure, but aims to reduce symptoms and improve qua…

This study looks at the long-term safety of a drug called dazodalibep for people with Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. About 844 adults who already completed a prior phase 3 study will receive the drug for up to 48 more weeks. Researchers …

This study tests a new drug, anvumetostat, combined with other treatments for people with advanced gastrointestinal, bile duct, or pancreatic cancers that have a specific gene deletion (MTAP). The main goals are to find the safest dose and check for side effects. About 350 adults…

This study tests whether adding two targeted drugs (sotorasib and panitumumab) to standard chemotherapy helps people with a specific type of advanced colorectal cancer (KRAS G12C mutation) live longer without their cancer growing. About 450 people who have not had prior treatment…

This study looks at whether adding Repatha® to usual care lowers the risk of major heart problems like heart attacks, strokes, or heart-related death in Chinese patients with hardened arteries. About 7,000 adults will be followed to compare those getting Repatha® plus standard ca…

This study tests whether the drug apremilast can reduce painful mouth ulcers in children aged 2 to 17 with Behçet's disease. About 60 children will receive either apremilast or a placebo for 12 weeks to see if the drug helps heal ulcers and reduce pain. The goal is to find a bett…

This study tests the long-term safety of avacopan in 300 adults with ANCA-associated vasculitis, a rare autoimmune disease that causes blood vessel inflammation. Participants receive either avacopan or a placebo alongside standard treatments. The goal is to see if avacopan is saf…

This early-stage study tests a new drug called AMG 410, alone or with other medicines, in people with advanced solid tumors that have a specific genetic change (KRAS alteration). The main goal is to find a safe dose and check for side effects. About 434 adults who have no other t…

This study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in 106 children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab reduces the number of…

This study tests a combination of two drugs, tarlatamab and ZL-1310, with or without a third drug (durvalumab) in people with small cell lung cancer that has come back after standard treatment. The main goal is to find safe doses and check for side effects. About 160 adults will …

This study tests whether adding xaluritamig to standard abiraterone therapy helps men with metastatic castration-resistant prostate cancer live longer. About 750 participants who have not had chemotherapy will be randomly assigned to receive the combination or another standard tr…

This study tests a new drug called maridebart cafraglutide in 180 adults who are overweight or obese and have high liver fat. Participants will receive the drug or a placebo, along with a reduced-calorie diet and more physical activity. The goal is to see if the drug safely reduc…

This study tests whether a new drug called ABP 692 works as well as the approved drug Ocrevus for people with relapsing-remitting multiple sclerosis (RRMS). About 444 adults with RRMS will receive either ABP 692 or Ocrevus to compare how the drugs move through the body, reduce ne…

This study tests a drug called etelcalcetide in children aged 28 days to under 18 years who have chronic kidney disease and are on dialysis. The goal is to see if the drug can safely lower high levels of parathyroid hormone, which can cause bone and heart problems. About 56 parti…

This study tests whether the drug avacopan, given alongside standard treatments, can help children aged 6 to 17 with active ANCA-associated vasculitis (a disease where the immune system attacks blood vessels) achieve remission. About 20 participants will receive avacopan plus eit…

This study tests whether Prolia can improve bone density in people whose bones have weakened from taking steroids. About 100 adults in China who are on steroid treatment will receive the drug and be monitored for 12 months. The main goal is to see if bone mass in the lower spine …

This study tests a new drug, maridebart cafraglutide, to see if it can reduce breathing pauses during sleep in adults with obstructive sleep apnea who are overweight or obese and not using a CPAP machine. About 250 participants will receive either the drug or a placebo for 52 wee…

This study tests a new drug called anvumetostat in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP deletion) and has not responded to at least one prior treatment. About 200 participants will receive the drug to see if it shrinks tumors an…

This study tests a drug called inebilizumab in children aged 2 to 17 with neuromyelitis optica spectrum disorder (NMOSD), a rare disease that causes inflammation in the eyes and spinal cord. The goal is to see how the drug works in the body, how safe it is, and whether it can hel…

This study tests whether adding the drug tarlatamab to standard chemotherapy helps people with advanced small-cell lung cancer live longer. About 330 adults who have not yet been treated will be randomly assigned to receive either the new combination or standard treatment alone. …

This early-phase study tests a new drug called xaluritamig in 40 adults with a type of advanced prostate cancer that has stopped responding to standard hormone therapy. The main goal is to check the drug's safety and side effects. Researchers will also measure how the drug moves …

This study tests a drug called inebilizumab in children aged 2 to 17 with generalized myasthenia gravis, a condition that causes muscle weakness. The goal is to see how the drug moves through the body, how safe it is, and if it helps control symptoms. About 15 children will take …

This study tests a new form of the drug tarlatamab given as a shot under the skin for people with extensive stage small cell lung cancer that has come back after chemotherapy. About 220 adults will take part to see if the shot is safe and how the body handles it. The goal is to c…

This early-phase study tests a new drug called anvumetostat, alone or with other treatments, in adults with advanced lung or chest cancers that have a specific genetic deletion (MTAP-deleted). The main goals are to find the safest dose and understand side effects. About 500 parti…

This study tests whether a new medication, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have both heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a pl…

This study tests a new medicine called AMG 732 for people with moderate-to-severe active thyroid eye disease, a condition that can cause bulging eyes and discomfort. The trial has two parts: first, healthy volunteers receive a single dose to check safety; second, people with the …

This early-stage trial tests an experimental drug called xaluritamig in about 50 people (adults, teens, and children) whose Ewing sarcoma has returned or stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will…

This study offers continued access to sotorasib (with or without panitumumab) for adults with advanced solid tumors who have a KRAS G12C mutation and were already benefiting from the drug in a previous Amgen trial. The main goal is to monitor safety and side effects over time. Ab…

This study looks at the long-term safety of the drug apremilast in children. It includes kids aged 2 and older with oral ulcers from Behçet's disease, or aged 5 and older with juvenile psoriatic arthritis. All participants must have completed a previous apremilast study. The main…

This early-stage study tests whether a new drug, maridebart cafraglutide, can help the body use insulin better in people with type 2 diabetes. About 57 adults aged 18 to 70 who are already taking metformin will receive either the drug or a placebo. The main goal is to measure cha…

This early-phase study tests a combination of two drugs, tarlatamab and AB248, in adults with extensive stage small cell lung cancer that has worsened after at least one prior treatment. The main goals are to check safety and find the best dose. About 380 participants will take p…

This study tests a drug called etelcalcetide in 24 children aged 2 to 17 who have high parathyroid hormone levels due to kidney disease and are on hemodialysis. The goal is to see if the drug safely lowers these hormone levels. Participants will receive the drug during dialysis s…

This study tests if a newer under-the-skin injection of pegloticase works as well as the standard IV infusion for people with uncontrolled gout. Both groups also take methotrexate weekly. The goal is to lower uric acid levels below 6 mg/dL for most of month 6. About 270 adults wi…

This early-stage study tests a new drug called AMG 513 in 80 adults with obesity to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather initial…

This study tests a new drug, maridebart cafraglutide, in people with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and urgent visits, and improves symptoms. About 5,056 adults with a BMI of 30 or higher will take the drug o…

This early-stage study tests a new drug called AMG 509, alone or with other medications, in people with a type of advanced prostate cancer that no longer responds to hormone therapy. The main goals are to check safety and how the drug moves through the body. About 479 participant…

This early-stage study tests a new drug called xaluritamig combined with standard hormone therapies (darolutamide or abiraterone) in 60 men whose prostate cancer has spread but still responds to hormone treatment. The main goal is to check safety and side effects, while also look…

This study tests a new treatment for older adults (55 and older, or 40-54 with certain health issues) who have a specific type of leukemia called Philadelphia-negative B-cell precursor ALL. The new approach combines a drug called blinatumomab with low-intensity chemotherapy, and …

This study tests a new drug, maridebart cafraglutide, in 250 adults with obstructive sleep apnea who are overweight or obese and already use a breathing machine (PAP therapy). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 …

This study follows children and teenagers with osteogenesis imperfecta (brittle bone disease) who previously received the drug romosozumab in an earlier trial. The goal is to monitor their long-term safety by tracking any side effects. No new treatment is given—just observation. …

This study compares two first-line treatments for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation and no PD-L1 protein. One group gets the targeted pill sotorasib plus chemotherapy; the other gets the immunotherapy pembrolizumab plus chemoth…

This study is testing a new way to give the drug blinatumomab—as a shot under the skin—for people with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to other treatments. The trial includes adults and adolescents aged…

This study tests a drug called olpasiran in people with stable heart disease and high levels of lipoprotein(a), a genetic risk factor. The goal is to see if olpasiran can reduce non-calcified plaque in the heart arteries compared to a placebo over 72 weeks. About 406 adults aged …

This study tests whether the drug apremilast can help children aged 5 to 17 with active juvenile psoriatic arthritis, a condition causing joint pain and skin problems. About 60 kids will receive either the drug or a placebo for 16 weeks. The main goal is to see if apremilast redu…

This early-phase study tests a new drug called AMG 436, alone or with other cancer treatments, in people with advanced solid tumors that have specific genetic changes (MSI-H or dMMR). The main goals are to check the drug's safety and find the best dose. About 464 adults with thes…

This study tests a new drug called xaluritamig, given alone or with hormone therapy, before prostate removal surgery in men with intermediate or high-risk prostate cancer. The goal is to see if the drug is safe and if surgery afterward is still possible. About 40 men will take pa…

This study tests whether olpasiran can prevent first major heart problems (like heart attacks or urgent procedures) in people aged 50+ who have high levels of lipoprotein(a), a genetic risk factor. About 11,000 participants will receive either olpasiran or a placebo. The goal is …

This early-stage study tests whether a new drug called AMG 691 is safe for people. It includes healthy volunteers and people with mild-to-moderate asthma. Researchers will give single or multiple doses and watch for side effects. The goal is to see if the drug is safe enough for …

This study tests two different forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. The main goal is to see how the body absorbs and processes each version. Participants receive a single dose and are monitored for side effects and drug levels ove…

This study is for pregnant women with migraine who have taken or not taken the drug AIMOVIG. Researchers will compare the number of babies born with major birth defects in each group. The goal is to understand if AIMOVIG is safe to use during pregnancy.

This early-stage study looks at how a new weight-loss medication, maridebart cafraglutide, changes the way oral contraceptives are processed in the body. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth co…

This study follows 60 women with NMOSD who received UPLIZNA during pregnancy or within 6 months before getting pregnant. Researchers will collect information on pregnancy outcomes, such as birth defects, preterm birth, and low birth weight. The goal is to better understand the sa…