Amgen

This study tests a drug called inebilizumab in 15 children (ages 2 to under 18) with IgG4-related disease, a rare condition that causes swelling and damage in organs. The main goals are to see how the drug works in the body and whether it is safe. Researchers will also check if i…

This study is for people with thyroid eye disease who did not respond to a previous treatment or whose symptoms returned. It tests a drug called AMG 732 to see if it can reduce eye bulging. About 30 adults will take part, and the main goal is to check for improvement after 24 wee…

This early-stage study tests a new drug, AMG 127, to see if it is safe and how the body processes it. The trial involves healthy adults aged 18-65 and people with type 2 diabetes aged 40-75. Researchers will monitor side effects and measure drug levels in the blood.

This study tests whether switching from common weight-loss drugs (GLP-1 receptor agonists) to a new medication called maridebart cafraglutide helps adults with obesity or overweight maintain weight loss. About 300 participants who have already lost at least 10% of their body weig…

This study tests if a shot under the skin (subcutaneous) of the drug blinatumomab works as well as the standard IV drip for adults with a certain type of leukemia (Ph-negative B-cell ALL). About 560 people who are in remission after initial chemo will be randomly assigned to get …

This early-stage study will compare two versions of evolocumab, a drug used to lower cholesterol, in 400 healthy adults aged 18 to 60. Participants will receive a single dose of one version, and researchers will measure how the drug moves through the body and check for side effec…