SYSTEMIC SCLEROSIS (SSC)

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases like rheumatoid arthritis or lupus, who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine is safe and triggers a…

This study is testing a new treatment for people with certain autoimmune diseases (rheumatoid arthritis, Sjögren's disease, myositis, or scleroderma) that have not responded to standard therapies. The treatment combines a natural killer cell therapy called AlloNK with the drug ri…

This study tests a new drug called tibulizumab for adults with systemic sclerosis, a rare disease that causes skin thickening and can affect internal organs. About 80 participants will receive either the drug or a placebo for 24 weeks, followed by an open-label period where every…

This early-stage study tests a new cell treatment called YTS109 in about 18 adults with autoimmune diseases like lupus or scleroderma that have not responded to standard therapies. Participants receive a single infusion of these modified immune cells. The main goal is to check sa…

This early-phase study tests a new mRNA drug called MTS109 in 15 people with moderate to severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and side effects, not to cure the disease. Participants receive the drug by IV and are monitored closel…

This early-phase study tests a new therapy called TI-0032-III for people with severe autoimmune diseases like lupus that haven't responded to other treatments. The therapy uses a special injection to create cancer-fighting cells inside the body that target and destroy faulty immu…

This study tests an investigational drug called efgartigimod in 81 adults with systemic sclerosis (scleroderma), a disease that causes skin thickening and organ damage. Participants receive either the drug or a placebo for up to 48 weeks. The main goal is to see if the drug reduc…

This early-stage study tests a new treatment called CT1190B CAR-T cell therapy in 27 adults with moderate to severe lupus or systemic sclerosis that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and calm the overactive …

This study is testing a new treatment using specially engineered immune cells (CAR-T cells) in children aged 5 and older with severe rheumatic diseases like juvenile dermatomyositis, arthritis, systemic sclerosis, and Sjögren's syndrome that haven't improved with standard therapi…

This study tests a new treatment using specially engineered immune cells (CAR-NK) from cord blood for people with severe autoimmune diseases like lupus, scleroderma, and vasculitis that haven't improved with standard treatments. The goal is to see if a single infusion can safely …

This early-phase trial tests an experimental treatment called QEL-005 in 16 adults with two autoimmune diseases: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically modifie…

This early-stage trial tests a new treatment for children with severe systemic sclerosis, a rare autoimmune disease that causes skin thickening and organ damage. The therapy uses the patient's own immune cells, modified to target and destroy faulty B cells. The study will enroll …

This early-phase study tests a new treatment called OL-CD19-GDT, which uses specially engineered immune cells (CAR-T cells) from a healthy donor to target and destroy faulty immune cells in people with severe systemic sclerosis or Sjögren's syndrome that have not responded to sta…

This early-stage study tests a universal CAR T-cell therapy designed to target and destroy certain immune cells (those with CD19 or BCMA markers) that drive autoimmune diseases. It enrolls 12 adults with severe conditions like lupus, scleroderma, or vasculitis that have not respo…

This early-stage study tests a new cell therapy called FT819 in people with moderate-to-severe autoimmune diseases like lupus, vasculitis, myositis, and scleroderma. The goal is to see if it is safe and can reduce disease activity by targeting faulty B-cells. About 244 participan…

This early-stage study is testing a new treatment for people with certain autoimmune diseases like lupus and kidney disease. The treatment uses specially engineered immune cells (CAR T-cells) that target and attack faulty immune cells causing the disease. The main goal is to chec…

This early-phase study tests the safety of a new drug called CC312 in up to 18 adults with autoimmune diseases like lupus, arthritis, or scleroderma that haven't responded to standard treatments. CC312 works by directing the body's immune T cells to attack faulty B cells, similar…

This early-stage study tests a new treatment called QT-219C, which uses specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells that cause autoimmune diseases like lupus and kidney disease. The treatment involves a one-time infusion after a short chem…

This study is testing a new blood test that may help doctors choose the most effective medicine for people with rheumatic diseases like rheumatoid arthritis, lupus, and vasculitis. Researchers will take a blood sample and use it to see how a person's immune cells react to differe…

This study tests whether injecting sodium thiosulfate directly into painful calcium deposits can shrink them and ease symptoms. It includes 20 adults with scleroderma, dermatomyositis, or mixed connective tissue disease who have calcium buildup in skin or tendons. Participants re…

This study tests whether special diets can reduce bloating and stomach pain in people with systemic sclerosis (scleroderma). Researchers will compare three diets—low FODMAP, CDED, and standard NICE guidelines—in 60 adults with moderate to severe bloating. The goal is to find whic…

This study tests whether a lotion containing 1% hemp extract (CBD) plus 10% urea can relieve itching, improve sleep, and hydrate skin in people with scleroderma. About 36 adults with chronic itching will use both the CBD lotion and a plain urea lotion at different times to compar…

This study tests if a person's own fat cells, processed and injected into the fingers, can improve hand function in people with systemic sclerosis (scleroderma). The trial will enroll 48 adults with hand stiffness and difficulty using their hands. Half will get the cell injection…

This study tests a biopsychosocial exercise program called BETY in 48 children and adults with scleroderma. The goal is to see if it improves physical function, skin health, and overall well-being. Participants are randomly assigned to BETY or standard care, and outcomes are meas…

This study tests if a wearable device called Apollo Neuro can help people with systemic sclerosis (a chronic autoimmune disease) feel less tired and have fewer Raynaud's attacks (where fingers turn white or blue in the cold). About 160 adults will use the device or a placebo vers…

This study looks at how scleroderma affects chewing and swallowing in both children and adults. Researchers will measure mouth opening, swallowing ability, and eating performance using simple tests and questionnaires. The goal is to better understand these problems and find the b…

This study aims to develop a better way to measure calcium deposits under the skin (calcinosis cutis) in people with scleroderma using CT scans. Researchers will test software that calculates the volume of these deposits and compare it to patient-reported symptoms. About 56 adult…

This study aims to find blood markers that could predict serious side effects from cancer immunotherapy. Researchers will measure interferon levels in 300 cancer patients starting immunotherapy and compare them to 40 people with autoimmune diseases like lupus. The goal is to deve…

This study looks at the link between nutrition and disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will assess the nutritional status of 460 participants using several standard tools and compare it to how a…

This study looks at how scleroderma affects physical abilities and daily functioning in both children and adults. Researchers will measure walking, stair climbing, and other tasks to understand the challenges patients face. The goal is to find better ways to support disease manag…

This study translates and tests a questionnaire called PASTUL, which helps people with scleroderma check the thickness of their skin on their arms and hands. Researchers will work with 50 Turkish-speaking adults who have scleroderma to make sure the Turkish version is accurate an…

This study tests whether artificial intelligence (AI) can help doctors find a serious lung condition called pulmonary arterial hypertension (PAH) earlier in people with systemic sclerosis (scleroderma). Researchers will compare AI-based screening to traditional methods in 350 adu…

This study tracks 70 people who have already received an infusion of KYV-101, a CAR T cell therapy, for autoimmune diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal is to watch for delayed side effects, new cancers, or other health problems over up to 15…