SYSTEMIC SCLEROSIS (SSC)

This early-stage study is testing a new type of treatment called CAR-T cell therapy for children and young adults with severe, hard-to-treat scleroderma. Doctors will collect a patient's own immune cells, modify them in a lab to target a protein called CD19, and then infuse them …

This early-stage study is testing a new, one-time treatment called TI-0032-III for people with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard drugs. The treatment uses an injection to genetically reprogram the patient's own immune cells …

This early-stage study is testing the safety of an experimental cell therapy called FT819 for four serious autoimmune diseases: lupus, vasculitis, myositis, and scleroderma. Researchers will give FT819 to 244 participants aged 12-70 who have moderate to severe disease that hasn't…

This study is testing whether a person's own fat tissue, processed to concentrate its regenerative cells, can improve hand function in people with systemic sclerosis (scleroderma). Researchers will inject these cells into the fingers of 48 participants and compare the results to …

This early study is testing the safety of a new drug called CC312 in adults with severe autoimmune diseases that have not improved with standard treatments. The drug works by engaging the body's own immune T cells to attack harmful B cells, using a mechanism similar to some advan…

This study is testing whether adding a new type of immune cell therapy (called AlloNK) to an existing drug (rituximab) can better control several autoimmune diseases that have come back after standard treatments. The trial will enroll 90 adults with rheumatoid arthritis, Sjögren'…

This early-stage study is testing the safety and initial effects of a new type of cell therapy for people with severe autoimmune diseases that haven't responded well to standard treatments. The therapy, called 'universal' CAR-T, uses donated immune cells engineered to target and …

This early-stage study is testing a single infusion of 'universal' CAR T-cells in adults with severe autoimmune diseases like lupus and scleroderma that have not improved with standard treatments. The therapy aims to target and remove harmful immune cells to potentially control t…

This is an early-stage study to check the safety of a new treatment called OL-CD19-GDT, a type of CAR-T cell therapy, for adults with severe autoimmune diseases that haven't responded to other treatments. The study will enroll 44 people with conditions like systemic sclerosis or …

This is an early-stage study testing a new type of cell therapy called BCMA/CD70 CAR-T for children with severe rheumatic diseases that have not responded to standard treatments. The trial aims to see if this therapy is safe and can reduce disease activity in conditions like juve…

This is an early-stage study to check the safety of a new cell therapy called YTS109 for adults with severe autoimmune diseases that have not responded to standard treatments. About 18 participants with conditions like lupus, scleroderma, or vasculitis will receive a single infus…

This study is testing whether a drug called efgartigimod, given as an injection under the skin, can help control the disease in adults with systemic sclerosis (scleroderma). About 81 participants will receive either the drug or a placebo for up to 48 weeks to see if it reduces sk…

This study is testing whether an investigational drug called tibulizumab can help control systemic sclerosis, a rare autoimmune disease that causes skin thickening and can damage internal organs like the lungs. For the first 24 weeks, some participants will receive the drug while…

This early-stage study is testing a new cell therapy for people with severe autoimmune diseases that haven't improved with standard treatments. Doctors will give patients specially engineered immune cells (CAR-NK cells) to try to reset their overactive immune systems. The main go…

This early-stage study is testing a new treatment called CT1190B CAR-T cell therapy for adults with severe lupus or scleroderma that hasn't responded to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to potentially fight the disease, …

This study aims to see if artificial intelligence (AI) can improve the early detection of a serious lung condition called pulmonary arterial hypertension (PAH) in people with scleroderma. Researchers will use AI to analyze simple test results like heart scans and compare its accu…

This study is testing a new blood test designed to predict which arthritis medications will work best for individual patients before they start treatment. Researchers will analyze blood samples from 120 people with various autoimmune rheumatic diseases to see if the test can accu…

This study is testing a special exercise program called BETY, designed to help manage the symptoms of scleroderma. It will involve 48 children and adults with the condition. The goal is to see if this program can improve physical function, skin health, and overall well-being.

This study is testing whether a wearable device called Apollo Neuro can help people with systemic sclerosis (scleroderma) manage their two most troubling symptoms: severe fatigue and Raynaud's phenomenon (painful cold fingers/toes). 160 participants will wear either the real devi…

This study is testing if a lotion containing cannabidiol (CBD) and urea works better than urea lotion alone to relieve severe itching in people with systemic sclerosis (scleroderma). Researchers will enroll 36 participants to see if the CBD lotion improves skin moisture, sleep qu…

This study is testing whether injecting a medication called sodium thiosulfate directly into painful calcium deposits under the skin can shrink them and reduce pain. It will involve about 20 adults with connective tissue diseases like scleroderma or dermatomyositis who have these…

This study is testing whether specific diets can help reduce severe bloating, abdominal pain, and other gut symptoms in people with systemic sclerosis (scleroderma). Researchers will compare three different dietary approaches in 60 participants to see which works best. The goal i…

This study aims to understand if a person's nutritional status is linked to how active their rheumatic disease is. Researchers will assess the diet and body measurements of 460 patients with conditions like rheumatoid arthritis and lupus. The goal is to gather knowledge that coul…

This study is creating a Turkish version of a questionnaire that lets scleroderma patients report on their own skin thickness. Researchers will work with 50 adult patients to translate and test the questionnaire, ensuring it is clear and works well for Turkish speakers. The goal …

This study aims to understand how scleroderma affects the ability to chew and swallow in both children and adults. Researchers will measure chewing and swallowing performance using simple tests and questionnaires. The goal is to gather information to help improve future care and …

This study aims to understand the complete picture of how scleroderma affects people's lives. Researchers will observe 50 children and adults with the condition, measuring their physical performance, pain, mental health, and social participation. The goal is to gather detailed in…

This study aims to test new software that measures calcium deposits in the skin of people with scleroderma using CT scans. Researchers want to see if these detailed measurements match up with patients' reports of pain and disability. The goal is to create better tools for future …

This study aims to find a way to predict which cancer patients might develop serious side effects from immunotherapy drugs. Researchers will compare blood samples from 300 cancer patients starting immunotherapy with samples from 40 people who have autoimmune diseases. They are lo…

This study is tracking the long-term safety and effects of an experimental cell therapy called KYV-101 in people who have already received it. Researchers will follow 70 participants for up to 15 years to check for any delayed side effects and see how long the treatment's effects…