SYSTEMIC LUPUS ERYTHEMATOSUS

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This early-phase study tested an experimental drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). The goal was to see if multiple injections under the skin are safe and how the drug moves through the body. Researchers tracked side effects and drug levels in…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study tested four doses of cenerimod, a daily pill that calms the immune system, against a placebo in 427 adults with moderate-to-severe lupus. The main goal was to see if cenerimod could reduce lupus disease activity over six months. Researchers also checked for safety and …

This study tested an experimental drug called enpatoran in 456 people with lupus, a chronic autoimmune disease. Participants took either a low, medium, or high dose of enpatoran or a placebo for 24 weeks. The goal was to see if the drug safely reduces skin and overall disease act…

This study tested a new drug called cenerimod in 105 people with systemic lupus erythematosus (SLE), an autoimmune disease. The goal was to see if the drug could safely lower certain immune cells (lymphocytes) in the blood, which may help control the disease. Participants continu…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This study looked at whether adding belimumab to standard treatment is safe and effective for Chinese children aged 5 to 17 with active lupus. 67 participants received the drug combination and were monitored for side effects and disease activity over a year. The goal was to see i…

This study tested whether the drug nipocalimab can help control active lupus better than a placebo. It involved 228 adults with lupus who had moderate to severe symptoms. The main goal was to see if more people taking nipocalimab had a significant reduction in disease activity af…

This study tested an experimental drug called KZR-616 in 69 adults with lupus, some of whom also had kidney inflammation (lupus nephritis). The drug was given as a weekly injection for 13 or 24 weeks. The main goals were to check safety and see if it could reduce protein in the u…

This study tested whether a single infusion of stem cells from donated umbilical cords could help adults with lupus that doesn't respond well to standard treatments. 81 participants received either the stem cells or a placebo, along with their usual care. The main goal was to see…

This study looked at the long-term safety and effectiveness of Benlysta, a medication for systemic lupus erythematosus (SLE), in over 1,500 patients in everyday medical practice. Researchers tracked participants for 52 weeks, monitoring side effects, disease activity, and quality…

This study tested the drug tofacitinib in 13 young adults aged 18 to 45 with moderate to severe lupus skin disease. The goal was to see if the drug is safe and can reduce skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how well it worked using a…

This early-stage study tested a drug called telitacicept in 16 children with lupus. The goal was to see how the drug moves through the body and if it helps control the disease. While not a cure, it may offer a new way to manage lupus symptoms in young patients.

This study tested an oral medication called GLPG3667 in 186 adults with active systemic lupus erythematosus (SLE). Participants took the drug or a placebo once daily for 48 weeks. The goal was to see if the drug could reduce lupus disease activity and improve symptoms, while moni…

This study tested a new drug, DS-7011a, in 26 adults with systemic lupus erythematosus (SLE), an autoimmune disease that causes inflammation and organ damage. The main goal was to check the drug's safety and how the body processes it. This is an early-stage trial, so it focuses o…

This study tested whether taking coenzyme Q10 (a natural supplement) along with standard lupus treatment can improve health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either CoQ10 or a placebo for 3 months. Researchers measured changes in …

This study looked at whether the drug anifrolumab, when added to standard care, can prevent long-term organ damage in adults with active systemic lupus erythematosus (SLE). Researchers compared data from 561 patients who received anifrolumab in earlier trials to similar patients …

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to standard treatment could better control the disease and reduce symptoms over 52 weeks. A total of 93 children took part, receiving either belimumab or …

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study looked at the long-term safety of an experimental drug called BMS-986165 in people with systemic lupus erythematosus (SLE). A total of 261 participants who had already completed an earlier lupus study were enrolled. Researchers tracked side effects, serious health even…

This study tested whether taking probiotics (beneficial bacteria) can help people with active lupus, an autoimmune disease. Forty adults with lupus took probiotics to see if it would reduce disease activity and improve their quality of life. The goal was to find a simple, safe wa…

This study tested whether hydroxychloroquine, a drug already used for lupus, could slow or prevent the disease in 187 people who had early signs but not full lupus. Participants received either the drug or a placebo for a period, and researchers tracked how many developed full lu…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested whether practicing Qi Gong, a gentle mind-body exercise, could improve quality of life in people with systemic lupus erythematosus (SLE). Thirty-three participants took part in weekly Qi Gong sessions for six months. Researchers measured changes in physical func…

This phase 2 study tested whether JBT-101 (lenabasum) can reduce joint pain in people with systemic lupus erythematosus (SLE). 109 adults with active arthritis and at least moderate pain took either the drug or a placebo for 84 days. The main goal was to see if pain scores improv…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study tested a program to help African American adults with lupus manage stress. Thirty participants learned stress-reduction techniques and had their stress levels and quality of life measured. The goal was to see if the program could lower stress and improve well-being.

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study looked at whether a computer-based decision-aid could help people with lupus and their doctors make better treatment decisions together. Nearly 1,900 adults with lupus from multiple clinics took part. The main goal was to see how many eligible patients actually used th…

This study looked at how lupus impacts the emotional and social lives of 160 patients and their spouses. Researchers measured quality of life and gathered insights to help doctors offer better support. The goal is to improve care for both patients and their partners.

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This study looked at whether an intensive care management program with a nurse manager could help high-risk lupus patients receive better outpatient care and reduce avoidable emergency room visits and hospital stays. Researchers enrolled 35 adults with lupus who had a recent hosp…

This study looked at how lupus changes the way the body adapts to exercise. Researchers included 55 adults with lupus in a 12-week high-intensity aerobic exercise program. They measured changes in fitness and fatigue to understand how the immune system affects exercise benefits.

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study looked at how faithfully people with lupus take their hydroxychloroquine (Plaquenil). Researchers used a simple questionnaire to measure compliance in 102 patients. The goal was to find which questions best identify those who skip doses, so doctors can catch problems e…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This study looked at gene activity in B cells (a type of immune cell) from 30 people with non-active systemic lupus erythematosus and compared it to healthy donors. The goal was to find what makes lupus B cells different, even when the disease is quiet. No treatment was given; it…

This study looked at over 107,000 people in Germany to understand the long-term side effects of steroid medications (glucocorticoids) used for conditions like asthma, arthritis, and lupus. Researchers compared those who took steroids with those who did not, tracking problems like…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other doesn't. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, includ…

This study looked at how lupus affects breathing, daily activity, and tiredness. Researchers compared 50 people with lupus to healthy volunteers using breathing tests, a 6-minute walk, and questionnaires. The goal was to find early signs of lung problems so doctors can treat them…

This study looked at 621 adults with moderate to severe lupus to see how active their disease was during doctor visits. Researchers collected information from past and current medical records to measure disease activity using a standard scoring tool. The goal was to better unders…

This study tested whether a short training for rheumatologists could help them provide more equitable care to Black/African American and lower-income patients. Over 200 patients and their doctors took part. The training focused on seeing each patient as an individual rather than …

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…