SQUAMOUS CELL CARCINOMA

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, many would also get radiation afterward to lower the risk of cancer coming back. But radiation has side effects. This trial tests whether patients with a negative blood test tw…

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink advanced squamous cell cancers of the nasal cavity and sinuses better than chemotherapy alone. About 35 adults with newly diagnosed, untreated stage II to IVb disease …

This study tests whether using special lasers followed by a medicated ointment can effectively treat two common types of skin cancer: squamous cell carcinoma and basal cell carcinoma. About 100 adults with biopsy-confirmed skin cancer will receive the laser treatment and then app…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electrical pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink …

This early-phase trial is testing a new treatment called VET3-TGI, a virus engineered to attack cancer cells. It is given alone or with the immunotherapy drug atezolizumab to up to 60 adults with advanced solid tumors that have not responded to standard treatments. The main goals…

This phase 2 trial tests whether a gene therapy gel called BVEC can reduce the return of squamous cell carcinoma (a type of skin cancer) in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition that causes fragile, blistering skin. The gel is app…

This study tests whether the drug afatinib can shrink tumors in people with advanced cutaneous squamous cell carcinoma (a type of skin cancer) that cannot be treated with surgery or radiation. About 25 adults with adequate organ function will receive afatinib, and researchers wil…

This early-phase study tests whether injecting the numbing drug lidocaine directly into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with oropharyngeal cancer will receive either lidocaine or no injection befor…

This study tests a new drug called HMBD-001 combined with cetuximab, with or without docetaxel, in people with advanced squamous cell cancers (like lung, head and neck, or cervical cancer). The goal is to see if the combination is safe and helps control the cancer for longer. Abo…

This study tests which chemotherapy combination works better when given with radiation for advanced head and neck cancer. About 120 adults with stage III or IV disease will receive either cisplatin or a mix of docetaxel and cetuximab. Researchers will also check if a tumor marker…

This study tests a new treatment called T3011, a virus injected directly into tumors, for people with advanced or metastatic solid tumors that have not responded to standard therapies. About 30 participants will receive T3011 alone or with another drug (pembrolizumab) to see if i…

This study tests whether using a special dye and camera during throat surgery can help prevent a common complication called a pharyngocutaneous fistula (PCF), which is a leak in the throat tube. The dye shows which tissues have poor blood flow, and surgeons remove those areas to …

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study tests an experimental cell therapy for advanced non-small cell lung cancer. Doctors take immune cells from a patient's tumor, grow them in large numbers, and give them back to the patient to fight the cancer. The goal is to see if this treatment can shrink tumors and h…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This pilot study is testing whether a handheld laser probe, called Raman spectroscopy, can measure the size of skin cancer tumors. Twenty people with basal or squamous cell carcinoma who are already scheduled for brachytherapy will have their tumors scanned with the probe. The go…

This study is testing a new platform that uses advanced testing to get a complete picture of a person's tumor. The goal is to see if this detailed information can help doctors choose better treatments for patients with high-risk cancers like leukemia, multiple myeloma, and pancre…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests whether MRI scans can help doctors adjust radiation therapy for head and neck cancer patients to better protect healthy organs like salivary glands and the throat. About 35 adults with certain types of head and neck cancer will receive standard radiation plus an …

This study tests whether taking high-dose vitamin D for 6 days before photodynamic therapy (PDT) can improve the immune system's ability to fight nonmelanoma skin cancer. About 54 adults scheduled for Mohs surgery will be randomly assigned to vitamin D or placebo. Researchers wil…

This study compares pain sensitivity between 40 oral cancer patients and 40 healthy volunteers using pressure and tongue-stretch tests. Researchers aim to understand how nerve cells called Schwann cells contribute to oral cancer pain. No treatment is given; the goal is to gather …

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study follows 70 people with advanced skin cancers (like Merkel cell or squamous cell) who need treatment before surgery. It tracks how long it takes to get insurance approval for drugs that are not yet FDA-approved for their cancer type, and what costs patients pay out-of-p…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatment than others, even when their cancer stage is the same. By gathering data from routine care, they hope to i…