SQUAMOUS CELL CARCINOMA

This study tests whether a gene therapy called BVEC can help prevent squamous cell carcinoma (a type of skin cancer) from returning after it is removed in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition that causes fragile, blistering skin.…

This early-phase study tests a new treatment called VET3-TGI, a virus designed to attack cancer cells and boost the immune system. It is for adults with advanced solid tumors that have not responded to standard therapies. The study aims to find a safe dose when given alone or com…

This study tests whether using special lasers followed by a skin ointment can effectively treat common skin cancers like basal and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancer will receive the laser treatment and apply the ointment for five nights. …

This study tests which of two chemotherapy combinations works better when given with radiation for advanced head and neck cancer. About 120 participants will receive either cisplatin or a mix of docetaxel and cetuximab. Researchers will also check if a tumor marker called ERCC1 h…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that can't be treated with surgery or radiation. About 25 adults will take afatinib pills daily. The main goal is to see how many patients have their tumors shrink or di…

This study tests whether giving chemotherapy and immunotherapy before standard surgery can shrink head and neck tumors enough to allow less extensive, function-preserving surgery. It enrolls 75 adults with newly diagnosed advanced head and neck cancer, including HPV-related and H…

This study tests a new treatment called T3011, a virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for 30 adults with advanced solid tumors like melanoma or lung cancer that have not responded to standard treatments. The goal is to che…

This study tests a new treatment for advanced squamous cell cancer of the nasal cavity or sinuses. It combines the immunotherapy drug pembrolizumab with chemotherapy (docetaxel and cisplatin/carboplatin) and radiation. The goal is to see if this combination shrinks tumors better …

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electric pulses to help the chemotherapy drug bleomycin enter cancer cells more effectively. The goal is…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers, including glioblastoma, breast cancer, and lymphoma. It is available to US patients whose doctors request it. Side effects are mostly mild, such as itchin…

This study is testing a new platform that uses advanced testing to get a complete picture of a person's tumor. The goal is to see if this detailed information can help doctors choose better treatments for patients with high-risk cancers like leukemia, multiple myeloma, and others…

This study tests whether using MRI scans to adjust radiation therapy can reduce damage to nearby healthy organs in people with head and neck cancer. About 35 participants will receive a personalized radiation boost based on how their tumor responds. The goal is to lower side effe…

This study looks at whether people with certain cancers prefer getting their immunotherapy as a shot under the skin (subcutaneous) or through an IV drip. About 880 patients will try both methods and report which they like better. The goal is to understand patient preferences, not…

This study aims to understand how oral cancer causes pain by comparing pressure and stretch sensitivity between 40 oral cancer patients and 40 healthy volunteers. Researchers will measure pain thresholds and tongue movement discomfort. The goal is to learn more about pain mechani…