SQUAMOUS CELL CARCINOMA

This early-phase study tests whether injecting the numbing drug lidocaine directly into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with oropharyngeal cancer will receive either lidocaine or no injection befor…

This study tests a new drug called HMBD-001 combined with cetuximab, with or without docetaxel, in people with advanced squamous cell cancers (like lung, head and neck, or cervical cancer). The goal is to see if the combination is safe and helps control the cancer for longer. Abo…

This study tests whether using special lasers followed by a skin ointment (tirbanibulin) can effectively treat two common types of skin cancer: basal cell and squamous cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and then ap…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electrical pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink …

This study tests which chemotherapy combination works better when given with radiation for advanced head and neck cancer. About 120 adults with stage III or IV disease will receive either cisplatin or a mix of docetaxel and cetuximab. Researchers will also check if a tumor marker…

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Usually, some patients get radiation after surgery to lower the risk of cancer coming back. This trial tests whether patients with low or medium risk features and a negative blood test f…

This study tests a new treatment called T3011, a virus injected directly into tumors, for people with advanced or metastatic solid tumors that have not responded to standard therapies. About 30 participants will receive T3011 alone or with another drug (pembrolizumab) to see if i…

This study tests whether using a special dye and camera during throat surgery can help prevent a common complication called a pharyngocutaneous fistula (PCF), which is a leak in the throat tube. The dye shows which tissues have poor blood flow, and surgeons remove those areas to …

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that cannot be treated with surgery or radiation. About 25 adults will take afatinib pills, and researchers will measure how many patients respond and how long the cance…

This study tests an experimental cell therapy for advanced non-small cell lung cancer. Doctors take immune cells from a patient's tumor, grow them in large numbers, and give them back to the patient to fight the cancer. The goal is to see if this treatment can shrink tumors and h…

This study tests a gene therapy called BVEC in 16 adults with a severe blistering skin condition (RDEB) who have had a type of skin cancer (squamous cell carcinoma) removed. The goal is to see if applying the therapy to the wound site can lower the chance of the cancer returning.…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink tumors better than chemotherapy alone in people with advanced squamous cell cancer of the nasal cavity or sinuses. About 35 adults with newly diagnosed, untreated stage II to …

This early-phase study tests a new experimental treatment called VET3-TGI, a virus designed to attack cancer cells. It is given alone or with another drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The main goals a…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers. The goal is to see if home treatment is preferred and just as safe. Participants will receive their usual cancer drugs at home from a specialized team, and researchers will …

This study tests whether using MRI scans to adjust radiation doses during treatment can reduce damage to nearby healthy organs in people with head and neck cancer. About 35 participants will receive standard radiation therapy, but part of the dose will be personalized based on MR…

This study tests whether a special laser imaging method, called Raman spectroscopy, can accurately measure how far skin cancer has spread. About 20 adults with basal or squamous cell carcinoma will have their tumors scanned with a handheld probe. The goal is to see if this techni…

This study aims to understand how oral cancer causes pain by comparing pressure and stretch sensitivity in 40 cancer patients and 40 healthy volunteers. Researchers will measure pain thresholds and tongue movement discomfort. No treatment is given; the goal is to gather knowledge…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study asks people with certain cancers whether they prefer getting their immunotherapy (nivolumab or pembrolizumab) as a quick shot under the skin or as a longer IV infusion. About 880 participants will try both methods and share their preference. The goal is to understand w…

This study looks at how common high-grade anal lesions (a pre-cancer condition) are in HIV-negative men who have sex with men (MSM) using PrEP. About 300 participants will provide anal swabs and undergo a special exam called high-resolution anoscopy to check for these lesions. Th…

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatment than others, even when their cancer stage is the same. By gathering data from routine care, they hope to i…

This study is collecting tumor samples from 300 people with high-risk blood or solid cancers, including leukemia, multiple myeloma, and pancreatic cancer. Researchers will use advanced lab tests to create a detailed profile of each tumor. The goal is to see if this information ca…