SQUAMOUS CELL CARCINOMA

This early-phase study tests a new treatment for people with widespread or multiple precancerous patches in the mouth. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, designed to target and destroy abnormal cells. The main goal is to check…

This study tests a combination of the immunotherapy drug toripalimab with two chemotherapy drugs (cisplatin and docetaxel) as an initial treatment for people with advanced head and neck cancer that has a specific marker (CPS-positive). The goal is to see if this approach is safe …

This study tests a new drug called IDP-001 in people with advanced or spreading solid tumors, including lung, head and neck, esophageal, cervical, and skin cancers. The goal is to see if the drug is safe, how the body processes it, and whether it can shrink tumors. About 132 adul…

This study tests whether adding fianlimab to the standard cemiplimab plus chemotherapy can better shrink tumors in adults with advanced HPV-positive head and neck cancer. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal i…

This study tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation can safely treat early-stage HPV-positive throat cancer. About 35 adults will take the drug daily for 10 days and receive one radiation treatment, followed by standard surgery. The go…

This study tests whether two chemotherapy drugs, cyclophosphamide and etoposide, can control advanced head and neck cancer in adults who have already tried standard treatment. About 120 participants will receive either the drug combo or a placebo for up to 6 months. Researchers w…

This study is testing a new type of radiation therapy, called Alpha DaRT, for people with a weakened immune system who have a type of skin cancer called squamous cell carcinoma. The treatment is given directly into the tumor. The goal is to see if it can shrink or control the can…

This study looks at whether taking vitamin D before a light-based treatment (photodynamic therapy, or PDT) can help the immune system fight nonmelanoma skin cancer. About 54 adults scheduled for skin cancer surgery will take either vitamin D or a placebo for 6 days before one PDT…

This study will test artificial intelligence (AI) software that analyzes video from routine endoscopies of the throat and voice box. The AI will try to find suspicious spots, tell if they are likely cancerous or not, and outline their edges. Researchers will compare the AI's resu…