SQUAMOUS CELL CARCINOMA

This study tests an experimental drug called RP1, which is injected directly into skin cancer tumors. The goal is to see if it can safely shrink or eliminate the cancer before surgical removal. About 12 adults with resectable cutaneous squamous cell carcinoma will receive the inj…

This study looks at whether giving lower doses of radiation to a smaller area after robotic surgery can still keep HPV-positive throat cancer from coming back. About 150 adults with early-stage throat cancer will receive this gentler radiation plan. The goal is to see if two year…

This study tests whether combining radiation therapy with an immunotherapy drug called cemiplimab can help people with a type of advanced skin cancer (cutaneous squamous cell carcinoma) that cannot be removed by surgery. About 34 participants will receive both treatments, and res…

This study tests whether adding bavituximab to pembrolizumab can help the immune system fight advanced head and neck cancer that has stopped responding to standard immunotherapy. About 7 adults whose cancer worsened after prior treatment will receive the combination. The main goa…

This study tests a new drug combination (pembrolizumab plus berahyaluronidase alfa) given as a shot under the skin for Japanese patients with advanced squamous cell skin cancer that has spread or cannot be removed by surgery. The main goal is to see if the treatment can shrink tu…

This early-phase trial is testing whether adding a cancer-killing virus (OBP-301) to standard chemotherapy and radiation is safe for people with advanced esophageal or gastroesophageal cancer who cannot have surgery. The study involves 16 participants and focuses on side effects …

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can help control advanced oral cancer. It includes 29 adults with newly diagnosed, stage 3-4 oral cavity squamous cell carcinoma that has a …

This study tests whether a lower dose of radiation therapy combined with the immunotherapy drug nivolumab works as well as the standard radiation-plus-chemotherapy approach for people with early-stage HPV-positive throat cancer who have never smoked. About 384 participants will r…

This study looks at whether remote check-ups (telemedicine) work as well as in-person visits for people with HPV-related throat cancer who show no signs of cancer after treatment. About 40 adults will be randomly assigned to either standard follow-up or tele-surveillance. Researc…

This study tests a small implantable device that delivers tiny amounts of different cancer drugs directly into skin cancer spots. The goal is to see which drug works best for each person's tumor. About 25 adults with squamous cell skin cancer will take part. The device is removed…

This study looks back at medical records of 72 American Indian patients treated with immunotherapy for cancers like lung, melanoma, and kidney cancer. Researchers want to see how well these treatments work compared to White patients and identify any differences in care. The goal …