SQUAMOUS CELL CARCINOMA

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can do a less extensive operation, preserving speech, swallowing, and vision. About 75 adults with newly diagnosed, advanc…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that cannot be treated with surgery or radiation. About 25 adults will receive afatinib and be monitored for tumor response and side effects. The goal is to control the …

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Usually, patients with certain risk factors get radiation after surgery, but this can cause long-term side effects. The trial uses a blood test two weeks after surgery to check for lefto…

This study tests whether a special imaging system (SPY Fluorescence) used during throat surgery can lower the risk of a pharyngocutaneous fistula — a leak in the throat tube. The dye helps surgeons see and remove tissue with poor blood flow, which can cause infection and leaks. A…

This early-phase trial tests a new treatment called VET3-TGI, a virus designed to infect and kill cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The main go…

This study tests a treatment that uses your own immune cells taken from your tumor, grown in a lab, and given back to you to fight advanced non-small cell lung cancer. The goal is to see if these cells can shrink tumors and if the treatment is safe. Participants must be 18-72 and…

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy and radiation can shrink tumors better than chemotherapy alone in people with advanced squamous cell cancer of the nasal cavity or sinuses. About 35 adults with newly diagnosed, untreat…

This study is for people with advanced head and neck cancer. It compares two different chemotherapy combinations given with radiation therapy to see which is more effective. The study uses a special marker in the tumor (ERCC1) to help guide treatment. About 120 participants will …

This study tests an experimental oral drug called NEO212 in adults with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it can slow tumor growth. About 134 participants will receive NEO212 a…

This study tests whether using fractional lasers followed by tirbanibulin ointment can effectively treat two common types of skin cancer: squamous cell carcinoma and basal cell carcinoma. About 100 adults with biopsy-confirmed skin cancers will receive the laser treatment and the…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink tu…

This study tests a new drug (HMBD-001) combined with standard treatments (cetuximab, with or without docetaxel) in people with advanced squamous cell cancers of the lung, head and neck, esophagus, cervix, skin, or nasopharynx. The goal is to see if the combination is safe and hel…

This study tests whether MRI scans can help doctors adjust radiation therapy for head and neck cancer patients to better target tumors while sparing healthy tissues. About 35 adults with squamous cell carcinoma will receive a personalized radiation boost based on MRI response. Th…

This study tests whether adding two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can improve outcomes for people with newly diagnosed, advanced oral cavity squamous cell carcinoma that has a specific marker (PD-L1 CPS pos…

This study tests a new treatment called T3011, given as a shot directly into tumors, for people with advanced or metastatic solid tumors (like melanoma or lung cancer). It is for adults whose cancer has worsened after standard treatments. The goal is to see if T3011 is safe and c…

This study tests a gene therapy gel applied to skin after removing squamous cell carcinoma (a type of skin cancer) in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare condition causing fragile, blistering skin. The goal is to see if the therapy can lower the …

This study is testing a new platform that uses advanced genetic and functional tests to better understand tumors from 300 people with various high-risk cancers, including leukemia, myeloma, and pancreatic cancer. The goal is to see if this detailed analysis can change the recomme…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study is gathering health information from 12,000 adults with lung or other chest cancers. Researchers want to see how factors like genes, lifestyle, and treatments affect outcomes in everyday medical practice. No new treatments are tested—just data collected to help doctors…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are in this group, how well anal swabs can detect them, and how these lesions affect quality of life. About 296 pa…

This study aims to understand why oral cancer hurts by comparing pain sensitivity between 40 oral cancer patients and 40 healthy volunteers. Researchers will measure how much pressure and tongue stretching causes pain. The goal is to learn more about the role of certain nerve cel…

This study looks at whether people with certain cancers prefer getting their immunotherapy (nivolumab or pembrolizumab) as a shot under the skin or as an IV drip. About 880 patients will try both methods and say which they like better. The goal is to understand patient preference…