SEDATION

This study looked at two common ways to help children aged 2 to 12 feel less anxious before an endoscopy (a scope procedure). One method was watching a short video, and the other was a nasal spray medicine called dexmedetomidine. Researchers measured anxiety levels at different t…

This study looked at whether a 50% oxygen and 50% nitrous oxide (laughing gas) mixture can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, catheter placements, or stitch removal. Researchers observed 100 children and measured pain using …

This study tested whether adding a painkiller called nefopam to standard care could reduce the amount of strong opioids needed for sedating critically ill patients on breathing machines. 60 adults participated in a double-blind trial. The goal was to see if nefopam could help pat…

This study tested three sedation approaches to make removing a Double-J ureteral stent more comfortable. Sixty adults received either propofol alone or propofol combined with dexmedetomidine or midazolam. Researchers measured how much propofol was needed and how sedated patients …

This study looked at whether playing music can improve how well sedation medicines work for children in the emergency department. 88 children who needed medicine for pain or to stay still during a procedure took part. Researchers measured how calm the children were, any side effe…

This study tested whether giving lidocaine through a vein can reduce muscle spasms in the duodenum during a procedure called ERCP. 120 adults scheduled for ERCP were randomly assigned to receive lidocaine or a placebo. The goal was to see if lidocaine lowers the need for extra sp…

This study tested whether an inhaled sedative (isoflurane) works as well as a common IV sedative (propofol) for keeping ICU patients calm while on a breathing machine. About 277 adults who needed sedation for more than 12 hours took part. The goal was to see if the inhaled method…

This study tested whether an inhaled anesthetic, isoflurane, given through a special device works as well as the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. About 282 adults who needed sedation for over 12 hours took part. The goal was to…

This study tested whether listening to music can lower stress and inflammation in sedated adults on breathing machines in the intensive care unit (ICU). Researchers measured stress hormones and inflammatory markers in the blood of 110 patients before and after a one-hour music se…

This study tested whether giving older adults a pill instead of IV sedation before cataract surgery is feasible and safe. Twenty participants aged 65 and older were randomly assigned to receive either a sedative pill or IV sedation. The goal was to see how well their thinking and…

This study looked at whether a special brain monitor (4-channel EEG) can help doctors give just the right amount of sedation during a procedure called ERCP. The goal was to keep patients safely asleep, avoid side effects, and help them wake up faster. 84 adults having elective ER…

This study looked at whether giving sedation through inhalation (breathing it in) instead of through an IV can reduce the work of breathing in patients on ventilators. 40 ICU patients were randomly assigned to receive either inhaled sedation or standard IV sedation. The goal was …

This study looked at 120 women having minor gynecologic surgery to see how different sedation drugs affect thinking skills right after the procedure. Patients received one of three drug combinations: propofol-fentanyl, ketamine-fentanyl, or a mix of all three. The main goal was t…

This study looked at 164 adults aged 65 and older who had a colonoscopy with sedation. Researchers wanted to see if frailty and the type of sedative used (propofol or dexmedetomidine) affected thinking and memory after the procedure. Participants took a simple mental test before …