SEDATION

This study tests if a gas sedative (isoflurane) given through a breathing tube works better than standard IV sedation (propofol) for critically ill patients. About 620 adults on ventilators who need deep sedation will be randomly assigned to one of the two methods. The main goal …

This program offers inhaled isoflurane via a special device to sedate adult ICU patients on breathing machines who are not well sedated with standard IV drugs. It aims to help patients who are agitated or at risk of harming themselves. The goal is to improve comfort and safety du…

This study compares a new sedative called ciprofol to the standard drug propofol in 366 ICU patients who need a breathing tube. The goal is to see if ciprofol can sedate patients just as well but with fewer episodes of dangerously low blood pressure. Participants will be randomly…

This study compares three sedation methods (dexmedetomidine, propofol, or both) in 1,000 adults having cataract surgery. The goal is to see which approach provides the best comfort and safety, including effects on heart rate, breathing, and side effects like nausea. Participants …

This study tests if a newer sedative, remimazolam, works better than the standard drug propofol for people undergoing endoscopy (a tube camera procedure). The goal is to see which drug provides safer and more comfortable sedation. About 100 adults having planned endoscopy will ta…

This study compares two ways to sedate children before cleft palate repair: a mix of two drugs (dexmedetomidine and ketamine) given through a nebulizer versus dexmedetomidine alone. The goal is to see which approach helps children separate from parents more easily and reduces agi…

This study looks at whether a sedative called remimazolam can help people in the intensive care unit (ICU) who are on breathing machines. Researchers will compare remimazolam to standard care in 80 adults to see if it leads to more days without a ventilator and fewer complication…

This study looks at whether a drug called remazolam besylate is as good as or better than another sedative (dexmedetomidine) for keeping critically ill patients calm and comfortable while they are on a breathing machine after non-cardiac surgery. About 306 adults aged 18-64 who n…

This study looks at two different computer programs that help doctors give sedation medicine to patients on breathing machines in the intensive care unit (ICU). The goal is to see which program keeps patients at the right level of sleepiness with fewer side effects. About 84 adul…

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will look at problems like nausea, low blood pressure, and kidney injury. The goal is to improve fasting guidelines for the millions of people who have procedures each y…

This study looks at whether blocking light with an eye shield during general anesthesia changes how much sedative medicine is needed. About 66 adults having surgery will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asleep, a…

This study tests a new brain activity monitor in 100 ICU patients who are on breathing machines and sedatives. The monitor uses a simple forehead patch to track brain signals and see if it matches standard checks for sedation and delirium. The goal is to find a better way to moni…