Sedation

This trial tests whether giving high-flow nasal oxygen during a sedated lung biopsy procedure (EBUS-TBNA) can reduce breathing complications like low oxygen levels and help patients recover more quickly. About 120 adults scheduled for this procedure will receive either high-flow …

Researchers are observing two standard sedation approaches for adults having an elective colonoscopy: propofol alone, or propofol combined with a low dose of ketamine. The study tracks blood pressure, heart rate, oxygen levels, and sedation depth using a brain monitor called the …

This study will compare two sedative drugs, remimazolam and dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing drug-induced sleep endoscopy. The goal is to see which drug provides more stable sedation, fewer side effects like low heart rate or low blood pressur…

This study tests whether playing a recording of a mother's voice can help reduce pain and the need for sedation in young children (ages 1-3) who are on mechanical ventilators in the intensive care unit. Half the children will listen to a 10-minute recording of their own mother re…

This study will test whether using only dexmedetomidine (an opioid-free sedative) during endoscopy procedures like colonoscopy and ERCP can reduce common side effects such as nausea, dizziness, and drowsiness compared to a standard opioid-based combination. Eighty adults schedule…

This study tests whether a new drug combination (anricofen plus ciprofol) can provide safer deep sedation for elderly patients undergoing ERCP, a procedure to treat bile duct problems. The goal is to reduce breathing complications and speed up recovery compared to the standard se…

This study tests whether a structured palliative care protocol, combined with staff training, can improve end-of-life care for ICU patients on ventilators. Researchers will compare the protocol to usual care across multiple centers. The goal is to ensure patients are comfortable …

This study tests whether giving flumazenil after hip replacement surgery can reverse the effects of the sedative remimazolam and improve thinking. 150 adults will receive either flumazenil or a placebo right after surgery. Researchers will check their memory and confusion levels …

This study tests a nasal spray containing dexmedetomidine to help patients relax before surgery, even with minimal monitoring. Researchers will compare it to a placebo in 564 adults to see if it causes fewer breathing or heart problems. The goal is to find a safer, easier way to …

This study tests if watching a virtual reality (VR) video of an MRI scan before the real thing can help children aged 5 to 10 stay calm and still. About 150 kids having their first MRI will be split into three groups: one watches the VR video at home and again at the hospital, on…

This study tests two different nose sprays—dexmedetomidine and ketamine—to see which one better calms children aged 2 to 6 before surgery. Sixty kids will receive one of the two sprays, and researchers will measure how sleepy they get and how easily they separate from their paren…

This study tests two different drug combinations given as a nasal spray to help patients relax during medical procedures. It includes 128 people aged 2 to 60 years old. The goal is to see which approach provides better sedation, faster recovery, and fewer side effects.

This observational study will monitor brain activity (EEG) in 330 people during anesthesia or sedation to see how it relates to drug levels and patient factors. It includes children with and without autism, adults over 70, and adults having sedation for endoscopy. The goal is to …