SEDATION

This study tests whether a nasal spray containing dexmedetomidine can safely sedate patients before surgery with minimal monitoring. About 564 adults will receive either the spray or a placebo 45 minutes before anesthesia. Researchers will track breathing and heart problems, how …

This study tests whether using a special brain monitor (BIS) can help doctors give the right amount of sedation to patients on breathing machines. The goal is to see if it reduces time on the ventilator, shortens ICU stays, and lowers the total sedation medication used. The trial…

This study tests two different nasal sprays—dexmedetomidine and ketamine—to see which one works better at calming children before surgery. About 60 children aged 2 to 6 will receive one of the sprays before their operation. The goal is to find a more effective and easier way to r…

This study looks at whether a special training program for ICU staff can improve care for patients on breathing machines when life support is being withdrawn. About 720 adults in intensive care will take part. The goal is to make patients more comfortable and support their famili…

This study tests whether a new combination of sedative and painkiller (anricofen plus ciprofol) can provide safer deep sedation for elderly patients (ages 60–90) undergoing a bile duct procedure called ERCP. The goal is to reduce breathing problems and side effects like nausea, w…

This study compares two types of sedation (midazolam with fentanyl vs. dexmedetomidine) given as a nasal spray to patients aged 2 to 60 years undergoing medical procedures. The goal is to see which provides better comfort, faster recovery, and fewer side effects. The trial will e…

This study tests whether watching a virtual reality (VR) video before an MRI scan can help children aged 5 to 10 stay calm and still. The VR video shows what the MRI machine looks like and sounds like, so kids know what to expect. The goal is to reduce movement, the need for seda…

This study tests whether giving flumazenil after hip replacement surgery can prevent confusion and memory problems. 150 adults having hip surgery under spinal anesthesia will receive either flumazenil or a placebo. Researchers will check thinking skills and delirium rates in the …

This study watches brain activity (EEG) in 330 people during routine anesthesia or sedation. It includes children (some with autism), adults over 70, and patients having digestive procedures. The goal is to find patterns that show how deep anesthesia is, without changing any stan…

This study will compare two sedative drugs, Remimazolam and Dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing a throat exam called Drug-Induced Sleep Endoscopy. Researchers will measure how stable the sedation is, side effects like low heart rate or blood pres…