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Can a small dose of ketamine make colonoscopy sedation safer?

NCT ID NCT07809230

Symptom relief Sponsor: Ankara Etlik City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are observing two standard sedation approaches for adults having an elective colonoscopy: propofol alone, or propofol combined with a low dose of ketamine. The study tracks blood pressure, heart rate, oxygen levels, and sedation depth using a brain monitor called the Bispectral Index. It also measures how much propofol patients need, how quickly they recover, and when they are ready to go home.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low-dose ketamine added to propofol sedation
What this could lead to
If adding low-dose ketamine helps, it could give colonoscopy patients steadier blood pressure and a smoother recovery from sedation.
What could go wrong
This is a small observational study of 100 adults with mild health status, so it cannot prove cause and effect. Ketamine can cause vivid dreams or confusion, and results may not apply to sicker or older patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective colonoscopy * ASA physical status I-II Exclusion Criteria: * ASA physical status ≥ III * Allergy to propofol or ketamine * History of psychiatric illness * Advanced cardiac disease * Pregnancy * Chronic use of opioids or sedatives * Inability to cooperate * Body Mass Index (BMI) \> 35 kg/m\^2

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colonoscopy procedures Sedation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Etlik City Hospital

    Altındağ, Ankara, 06000, Turkey (Türkiye)

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