POST OPERATIVE PAIN

This study compares two nano-sized medications placed inside the tooth after a root canal retreatment to see which better controls inflammation and pain. Sixty-three adults with a failed prior root canal and a visible infection at the tooth tip will be randomly assigned to receiv…

This study compares two ways to manage pain after a planned cesarean section: a nerve block (erector spinae plane block) versus morphine given during spinal anesthesia. The goal is to see which method helps mothers recover better and feel more comfortable during their hospital st…

This study compares two ways of doing root canals: a newer manual-less technique and the standard rotary method. The goal is to see which causes less pain afterward and how it affects natural pain-related chemicals. About 34 adults with infected back teeth will take part.

This study tests whether adding a drug called Suzetrigine to standard pain management can lower the amount of opioids needed after weight-loss or heart surgery. About 235 adults aged 18-85 will take part. The goal is to reduce pain and opioid use, helping patients recover with fe…

This study compares two methods for controlling pain after outpatient orthopedic surgeries like ACL repair or rotator cuff surgery: a continuous pain pump versus a single nerve block given before surgery. About 80 adults will be randomly assigned to one of the two groups. The goa…

This study compares pain levels after root canal treatment using two different sealing materials: a resin-based sealer and a bioceramic sealer. 180 adults with tooth pain will be randomly assigned to one of the two groups. Pain will be measured 24 and 48 hours after the procedure…

This study tests whether an ultrasound-guided nerve block can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having elective ear surgery will either receive the block or standard care. The goal is to see if this approach leads to less op…

This study looks at whether a long-lasting numbing medicine (liposomal bupivacaine) can reduce the need for strong painkillers after spinal fusion surgery in teens with scoliosis. About 128 teens aged 10–17 will be randomly assigned to get either the long-lasting numbing drug or …

This study tests whether a presacral nerve block can reduce pain after total laparoscopic hysterectomy. About 60 women will receive either the nerve block or a placebo (sham) injection. The main goal is to measure pain levels 3 hours after surgery using a simple 0-10 pain scale.

This study compares two methods of pain control after total shoulder replacement: a continuous nerve block catheter versus a single injection of long-lasting medication. About 56 adults having reverse shoulder replacement will be randomly assigned to one of the two groups. The go…

This study tests whether giving a single dose of methadone during hip replacement surgery can lower pain and reduce the need for other opioids afterward. Researchers will enroll 162 adults aged 18-75 who are having elective hip replacement. The goal is to improve pain control and…

This study tests whether taking a corticosteroid (prednisone) after ureteroscopy—a surgery to remove kidney stones—can help reduce pain and the need for extra painkillers. About 90 adults who are having this surgery with a stent placed will be enrolled. Researchers will compare p…

This study tests whether a pre-surgery program of exercise and a special nutritional drink (Ocoxin) can help women with gynecologic cancers recover faster after surgery. About 100 participants will follow this program alongside standard enhanced recovery steps. The goal is to see…

This study is testing whether giving methadone during and after major spine surgery can help patients use fewer opioids in the long run. About 120 adults having multi-level spine fusion will be randomly assigned to receive either methadone or a placebo. The main goal is to see if…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or surgery plu…

This study tests a small steroid insert placed in the tear duct to control pain and swelling after vitreoretinal eye surgery. About 30 adults having surgery for a macular hole, epiretinal membrane, or vitreomacular traction will either get the insert or standard steroid eye drops…

This study tests whether dextromethorphan, a common ingredient in cough syrup, can reduce pain and the need for opioid painkillers after total knee replacement. About 160 adults undergoing knee surgery will receive either the drug or a placebo before and after their operation. Th…

This study compares two ways to decide when surgery patients need extra pain medicine. One method uses a standard pain score, while the other also considers how much pain limits movement. The goal is to give painkillers only when truly needed, reducing overtreatment. About 76 adu…

This study compares two types of nerve blocks (SIFI and QIPB) for pain after hip fracture surgery. About 70 adults having hip fracture repair will receive one of the blocks, and their pain levels will be measured. The goal is to see which block provides better pain relief and red…

This study tests whether using a special laser along with ultrasound during a root canal can lower pain and kill more bacteria afterward. About 120 adults with infected single-root teeth will be randomly assigned to get either standard treatment or the laser-ultrasound combo. The…

This study looks at whether taking two common pain relievers (acetaminophen and NSAIDs) at different times works better than taking them together after a C-section. About 825 women who have a C-section will be randomly assigned to one of the two schedules. The goal is to find the…

This study tests whether injecting a long-acting anesthetic called EXPAREL into the surgical wound can reduce pain and improve swallowing after robotic surgery for throat cancer. About 80 adults having this surgery will be split into two groups: one gets EXPAREL plus standard pai…

This study tests whether giving acetazolamide (Diamox) before laparoscopic hysterectomy can reduce pain caused by gas used during surgery. About 100 women aged 21-65 having the procedure for non-cancer reasons will take either the drug or a placebo. Researchers will track pain sc…

This study compares two types of ultrasound-guided nerve blocks (S-FICB and PENG) to see which one better reduces pain when patients with a broken femur need to sit up for spinal anesthesia. About 70 adults aged 20-70 will take part. The goal is to make positioning less painful a…

This study looks at two common ways to give morphine for pain after a planned C-section: injecting it into the spinal fluid or into the space around the spinal cord. Researchers want to find out which method provides better pain control with fewer side effects. About 120 women ha…

This study tests whether a pain management plan without opioids works just as well as one with opioids after a tubal sterilization procedure. About 120 women having minimally invasive surgery will be randomly assigned to one of two pain control approaches. The goal is to see if w…

This study looks at a technique called cryoanalgesia, where doctors freeze certain nerves in the chest during surgery to reduce pain afterward. Researchers will track up to 5,000 patients for up to 5 years to see how well it works and if it's safe. The goal is to find a better wa…

This study compares three treatments for deep cavities causing severe tooth pain: total pulpotomy (removing the top part of the tooth's nerve), radicular pulpotomy (removing a bit more of the nerve), and standard root canal treatment. About 99 adults with deep decay in their lowe…

This study compares two ultrasound-guided nerve blocks—serratus intercostal plane block and erector spinae plane block—for pain control after open kidney removal surgery. About 132 adults aged 18-65 will receive one of the blocks during surgery. The goal is to see which block pro…

This study looks at whether a continuous pain pump delivering numbing medicine (bupivacaine) after a C-section can lower the need for stronger painkillers like opioids. About 100 pregnant adults having C-sections at a special care center will be randomly assigned to get either th…

This study compares two medications, dexmedetomidine and dexamethasone, added to a standard nerve block for arm surgery. The goal is to see which one helps the block work faster, last longer, and reduce the need for painkillers afterward. About 44 adults aged 18-70 having upper l…

This study tests whether a new pain drug called Suzetrigine can help people who have knee replacement surgery use fewer opioids and feel less pain. About 235 adults having knee replacement will be randomly assigned to get either Suzetrigine or a placebo before surgery. The resear…

This study tests a special nerve block (M-TAPA) to see if it reduces pain better than standard numbing medicine for children after laparoscopic belly surgery. Sixty children aged 1 to 7 will be randomly assigned to receive either the nerve block or the usual numbing injection at …

This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the amount of other opioids needed after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and half a pl…

This study looks at how much the temperature inside a tooth rises when dentists use red light compared to standard blue light during fillings. Researchers will also check if patients have any tooth pain afterward. The goal is to see if red light is gentler on teeth. About 50 heal…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks at the forces placed on the tongue and throat during laryngeal surgery and whether they cause pain, numbness, or other problems. Researchers will measure these forces in 100 adults having throat surgery. In the first 50 patients, surgeons won't see the measuremen…

This study is a large registry that collects information from 200,000 patients about their pain after surgery. The goal is to understand how well current pain treatments work and how patients feel about their pain management. No new treatments are given; the study simply observes…

This study looks at why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will collect small skin and blood samples to study genes and immune cells linked to pain. The goal is to find biological markers that could lead to bette…