POST OPERATIVE PAIN

This study tests a treatment called cryoneurolysis, which freezes nerves around the knee before total knee replacement surgery. The goal is to reduce pain and the need for strong painkillers (opioids) after surgery. About 100 adults with knee osteoarthritis will be randomly assig…

This study tests whether a nerve block (an injection near the neck nerves) plus local anesthetic can lower pain, nausea, and the need for strong painkillers after thyroid surgery. About 74 adults having part or all of their thyroid removed will be randomly assigned to get either …

This study aimed to see if a tiny dose of buprenorphine/naloxone could help control pain after surgery in people who already take strong painkillers. It was designed for adults having orthopedic or general surgery. However, the study was withdrawn before any participants were enr…

This study tests whether adding dexamethasone or dexmedetomidine to a standard numbing medicine (bupivacaine) can provide longer pain relief after rhinoplasty (nose job). 90 adults having nose surgery will receive one of these combinations as a nerve block. The main goal is to se…

This study compares two pain management strategies after knee or hip replacement surgery: using both tramadol and oxycodone versus oxycodone alone. The goal is to see if the combination reduces total opioid use, pain, and side effects. About 560 adults having their first knee or …

This study compares two types of nerve blocks—suprainguinal fascia iliaca block and pericapsular nerve block—to see which provides better pain relief after hip replacement surgery. Sixty adults undergoing hip replacement will be randomly assigned to receive one of the two blocks.…

This study looks at two different medicines placed inside a tooth during root canal treatment to see which one causes less pain and helps the infection heal better. Eighty adults with infected front teeth will receive one of the two medicines and report their pain levels over a w…

This study looks at how well patients recover after mastectomy surgery. Some patients receive a PECS nerve block with a long-lasting painkiller (liposomal bupivacaine), while others do not. Researchers want to see if the block leads to better recovery and less pain 72 hours after…