PANCREATIC NEOPLASMS

This study tests a new drug, LY3537982, in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to see if the drug is safe and shrinks tumors. About 540 adults with lung, colon, endometrial, ovarian, pancreatic, or bile duct cancers …

This study tests a new treatment for people with pancreatic cancer that has spread to the liver. The approach uses a multi-step process: first, a baking soda solution is infused into the liver to make the tumor environment less acidic, then chemotherapy and an immunotherapy drug …

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors, including mesothelioma, that have returned or spread after standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer ce…

This trial tests a new drug called UCB4594, an antibody that targets a protein (HLA-G) found on many cancer cells. The goal is to see if it helps the immune system attack tumors. It is for people with advanced solid tumors (like lung, breast, or colon cancer) that have not respon…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This study is testing a new way to treat pancreatic tumors using heat delivered through a thin tube during an endoscopy. It is for people whose tumors cannot be removed by surgery. The goal is to see if the procedure is safe and can shrink the tumors.

This study tests whether adding TQB2868 and anlotinib to standard chemotherapy can help people with pancreatic cancer live longer without their disease getting worse. About 80 adults with advanced pancreatic cancer who have not had prior treatment will receive the combination the…

This study looks at how the genetic makeup of pancreatic cancer affects response to FOLFIRINOX chemotherapy given before surgery. About 45 adults with non-metastatic pancreatic cancer will receive chemo, then have their tumors analyzed. The goal is to see if certain tumor types r…

This study aims to find pancreatic cancer or its early warning signs in people who have a strong family history of the disease or certain genetic mutations. Researchers will use MRI scans and collect blood samples over time to improve early detection. About 200 participants will …

This study is testing a new blood test that looks for tiny particles called exosomes to find pancreatic cancer early. The goal is to see if this test can accurately detect the disease in 2000 adults, including those with and without cancer. If successful, it could lead to a simpl…

This study compares two minimally invasive surgeries—laparoscopic and robot-assisted—for removing benign or pre-cancerous growths from the left side of the pancreas. About 256 adults will be randomly assigned to one of the two procedures. The goal is to see which approach leads t…

This study is testing a new test called NEO-Match® that uses nanomechanical profiling to see if it can predict how well pancreatic cancer patients respond to treatment. About 200 adults with suspected pancreatic cancer will provide an extra biopsy sample during their standard car…

This study collects blood, urine, tumor samples, and health information from up to 1,000 people with malignant mesothelioma and other cancers that express mesothelin. The goal is to build a tissue bank for future research, not to test a new treatment. Participants must be at leas…

This study is looking at tiny molecules called microRNAs in the blood of 200 people with advanced pancreatic cancer. Researchers want to see if these molecules can help diagnose the disease earlier, predict how it will progress, and show whether a treatment is working. The goal i…

This study looks at whether a special ultrasound done before surgery can tell how firm the pancreas is and predict the risk of a leak after pancreatic surgery. About 100 adults having this surgery will get the ultrasound, and doctors will compare its results to what they feel dur…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts grow and change over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and test results over up to …

This study looks at 206 people having surgery to remove a pancreatic tumor. It compares standard anesthesia to a combination of general anesthesia and an epidural to see which method causes fewer drops in blood pressure during the operation. The goal is to find the safer approach…

This study looks at whether people aged 50+ who recently developed diabetes or whose diabetes got worse might have early signs of pancreatic cancer. Participants will get an MRI scan and give blood samples over time to help create a future blood test. The goal is to catch pancrea…

This study looks at medical records from 1,000 adults with pancreatic cancer to see if personalized treatments based on each tumor's molecular profile work better than standard care. Researchers will check how often doctors follow treatment recommendations from a special tumor bo…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study follows 4,000 adults with pancreatic cysts to learn which ones turn into cancer and which stay harmless. Participants provide health updates over time, but no treatment is given. The goal is to help doctors decide when surgery is needed and when it can be safely avoide…