PANCREATIC DUCTAL ADENOCARCINOMA

This study tests whether adding the experimental drug ZN-c3 to standard chemotherapy (gemcitabine) can help people with advanced pancreatic cancer live longer without their disease getting worse. It involves 12 participants whose cancer has returned or not responded to prior plat…

This study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with cancers like pancreatic, lung, or c…

This study tests a new immunotherapy (a protein and virus combo) plus ezabenlimab in adults with advanced pancreatic cancer. The goal is to find a safe dose and see if the combination helps people live longer. Participants are split into two groups: one gets the new treatment, th…

This study tests a new combination of two experimental drugs (AGEN1423 and botensilimab), with or without standard chemotherapy, in people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors…

This early-phase trial tests a drug called ivosidenib combined with standard chemotherapy in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the combination shrinks tumors before surgery. Up to 16 participants will take…

This early-phase trial tests whether fecal microbial transplants (FMT) are safe and can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive FMT, which introduces healthy gut bacteria from donor stool. The study is currently suspended and …

This early-phase study tested a special vaccine (PANVAC) given directly into the tumor plus under the skin, along with a drug that boosts immune cells (sargramostim), in 18 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the …

This early-phase study tests a combination of two targeted drugs (vismodegib and erlotinib) with or without standard chemotherapy (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the safest d…

This study looks at how safe and effective glipizide, a standard diabetes drug, is for lowering blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide and have their glucose levels monitored. The goal i…

This study tests a new drug called chiauranib combined with two standard chemotherapies as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination can slow cancer growth and improve outcomes. About 42 …

This early-phase study tests a new drug called RMC-6291 in adults with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to find a safe dose and see how the body handles the drug. About 222 people with lung, colorectal, or pancreatic cancer that has not r…

This study compares a three-drug chemotherapy combination (nab-paclitaxel, gemcitabine, plus cisplatin) against the standard two-drug combination (nab-paclitaxel plus gemcitabine) for people with metastatic pancreatic cancer that has spread to other parts of the body. Only patien…

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. It involves 3 adults with newly diagnosed advanced or metastatic pancreatic cancer. The goal is to see if…

This study looks at whether a special heat probe, guided by an ultrasound camera, can help people with inoperable pancreatic cancer live longer. About 108 adults who cannot have surgery will either get standard care or also receive this heat treatment. The goal is to see if the h…

This study tests a new immunotherapy called ELI-002 7P for people with pancreatic or other solid tumors that have certain gene mutations (KRAS/NRAS). The treatment aims to help the immune system fight cancer cells after standard treatments like surgery and chemotherapy. About 158…

This early-stage study tests a new experimental drug (RO7496353) combined with an immunotherapy drug, with or without standard chemotherapy, in people with advanced lung, stomach, or pancreatic cancer. The main goal is to check safety and find the right dose. About 102 participan…

This early-phase study tests an experimental drug called ABBV-400 in about 302 adults with advanced solid tumors, including liver, pancreatic, breast, and ovarian cancers. The main goals are to check safety, side effects, and whether the drug shrinks tumors. Participants receive …

This study tests whether giving a single dose of chemotherapy directly to the liver, before standard treatment, is safe and possible for people with localized pancreatic cancer. About 20 adults who are eligible for surgery and standard chemo will take part. The goal is to see if …

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced or inoperable solid tumors, including certain breast, lung, and pancreatic cancers. The goal is to see if the combo can shrink tumors or slow their growth by blocking enzymes that cancer …

This study was designed to test a new type of PET scan that uses two special substances to find cancer cells with a marker called CA19-9. It was planned for people with pancreatic, bladder, or gastrointestinal cancers. However, the study was withdrawn before any participants were…

This study is working on a new way to detect pancreatic cancer earlier using a simple urine or blood test. Researchers are collecting samples from 3500 people with and without pancreatic disease to see if a panel of biomarkers can accurately identify cancer. The goal is to create…

This study tests whether a practical diet and exercise program can help people with certain pancreatic cysts lower their risk of developing pancreatic cancer. Twenty-four adults with large pancreatic cysts and excess weight will follow a 6-month program of physical activity goals…

This study looks at whether an 8-week program of personalized nutrition, exercise, and mental support can help people with pancreatic or esophageal cancer get stronger before surgery. About 9 participants will try the program, and researchers will check if they can complete most …

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This early-phase study tests whether a special PET scan tracer called 18F-FAC can measure how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 adults with pancreatic ductal adenocarcinoma will receive a PET scan before starting treatme…

This study collects blood samples from 102 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer to track genetic changes in tumor DNA over time. Participants continue their standard treatments while researchers measure how cancer DNA levels in the blood…

This study is creating a secure database of 317 patients at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to find better ways to detect the disease early or even prevent it. No new treatments are being tested; i…

This study is building a registry (a database) of people with BRCA or PALB2 gene mutations who have pancreatic cancer. The goal is to collect information and biological samples to help researchers learn why this cancer develops in some gene carriers. Up to 600 participants, inclu…