PANCREATIC DUCTAL ADENOCARCINOMA

This study is for people whose advanced pancreatic cancer has spread and has a specific genetic change (BRCA1, BRCA2, or PALB2 mutation). It compares a new three-drug chemotherapy combination (NABPLAGEM) against the current standard two-drug combination. The goal is to see if add…

This study is testing how well and safely the diabetes medication glipizide works to lower high blood sugar in people with pancreatic cancer. Researchers are enrolling about 29 participants with active pancreatic cancer and high blood sugar to measure their glucose levels before …

This early-stage study is testing the safety and initial effectiveness of a new drug called RO7496353 when given with an existing immunotherapy drug, with or without standard chemotherapy. It is for adults with advanced solid tumors that have spread or cannot be cured, including …

This study is testing whether adding an experimental drug called ZN-c3 to an approved chemotherapy (gemcitabine) can help control advanced pancreatic cancer that has worsened after initial treatment. The main goal is to see if this combination can keep the cancer from growing for…

This early-stage study is testing whether adding the drug ivosidenib to standard chemotherapy (mFOLFIRINOX) before surgery helps people with operable pancreatic cancer. The goal is to see if this combination is safe and effective at shrinking tumors before surgical removal. Resea…

This early-stage study is testing the safety and best doses of a combination of two or three drugs (vismodegib, erlotinib, and sometimes gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be removed by surgery. The goal is to see if blocking …

This early-stage study is testing a new drug called PF-08046052/SGN-EGFRd2 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goal is to find the safest dose and understand side effects in 65 participants with specific cancers includin…

This study is testing if a single dose of chemotherapy delivered directly to the liver artery is safe and practical for people with pancreatic cancer who are scheduled for surgery. The goal is to see if this extra step, given before the standard surgery and chemo, can help contro…

This early-stage study is testing an experimental drug called ABBV-400 in adults with advanced solid tumors that have spread or cannot be removed by surgery. It includes eight specific cancer types, such as liver, pancreatic, and certain breast cancers. The main goals are to chec…

This trial is testing a new immunotherapy called ELI-002 7P. It is for people with pancreatic or colorectal cancer that has a specific genetic change (KRAS or NRAS mutation) and who have already had surgery and chemotherapy. The goal is to see if this treatment can safely help th…

This early-stage study is testing whether adding three common cholesterol-lowering drugs to standard chemotherapy is safe and feasible for people with advanced pancreatic cancer. The idea is that by drastically lowering the body's cholesterol, the drugs might 'starve' the fast-gr…

This study is testing a new three-drug combination for people with advanced pancreatic cancer that cannot be surgically removed. It combines an experimental pill called Chiauranib with two standard chemotherapy drugs. The goal is to see if this combination can better control the …

This early-stage study is testing a new combination treatment for pancreatic cancer. It combines a cancer vaccine designed to train the immune system to attack cancer cells with an immunotherapy drug called ezabenlimab. The study aims to find safe doses and see if this approach c…

This study is testing whether taking two oral drugs, cediranib and olaparib, together can help control advanced cancers that have spread or cannot be surgically removed. It is for adults with specific types of advanced lung, breast, or pancreatic cancer who have already tried at …

This is an early-stage trial to test the safety and determine the right dose of a new experimental drug called LY4066434. The drug is designed to block a common cancer-driving protein called KRAS in people with advanced solid tumors, including pancreatic, lung, and colorectal can…

This early-stage study is testing a new vaccine therapy for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to find a safe dose and see if injecting the vaccine directly into the tumor, along with an immune-boosting drug, can help the body's …

This study aimed to test a new two-step PET scan method to better find cancer cells that produce a specific marker called CA19-9. It was designed for adults with certain cancers like pancreatic, bladder, or gastrointestinal tumors. The main goals were to find the safest dose and …

This study is testing whether a 6-month diet and exercise program is practical and acceptable for people with certain non-cancerous pancreas growths (IPMNs) who are at higher risk for pancreatic cancer. It enrolled 24 adults to see if they can stick to activity goals and nutritio…

This early study is testing whether ketorolac, a common anti-inflammatory pain medication, can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing significant weight loss (cachexia). Researchers will give 28 participants ketorolac for …

This study aims to understand why some people with BRCA or PALB2 gene mutations develop pancreatic cancer. Researchers are creating a registry (a database) of 600 people, including those with pancreatic cancer who carry these mutations, their relatives, and control groups. The go…

This study aims to create a large database of patient information to find better ways to detect pancreatic cancer early, when it's most treatable. It involves 317 adults at Moffitt Cancer Center who have pancreatic cysts, a strong family history of pancreatic cancer, or other ris…

This study is testing a new type of PET scan to see if it can show how much of a standard chemotherapy drug actually gets into pancreatic tumors. Researchers will scan about 30 patients with pancreatic cancer before they start treatment. The goal is to gather information that cou…

This study aims to learn how tracking cancer DNA in the blood relates to treatment response. It will observe 102 adults with lung, colorectal, or pancreatic cancer who are receiving standard care. Researchers will collect blood samples over time to see if changes in cancer DNA le…