MYELODYSPLASTIC SYNDROMES

This study tested an oral drug called ASTX727 in people with lower-risk myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to see if a lower dose given over a longer schedule could improve blood cell counts and reduce the need for transfusions. The trial enroll…

This study tested a drug called E7820 in 12 people with relapsed or hard-to-treat blood cancers (AML, MDS, or CMML) that have mutations in certain splicing factor genes. Participants took one pill daily to see if it could help control their cancer. The main goal was to measure ho…

This study tested a combination of chemotherapy (busulfan and etoposide) and total-body radiation given before a donor stem cell or bone marrow transplant. The goal was to see how well this regimen works and what side effects it causes in 30 patients with advanced leukemia or mye…

This study tested a new treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) who had not responded to standard therapy. The treatment involved giving patients chemotherapy followed by an infusion of donor immune cells that had been sp…

This completed study looked at 88 adults in China with lower-risk myelodysplastic syndromes (MDS) who had not received prior ESA therapy. Researchers tracked how often patients needed red blood cell transfusions and whether their hemoglobin levels improved while taking luspaterce…

This study tested a drug called luspatercept in 30 adults from China and Japan who have a bone marrow disorder (MDS) and need regular red blood cell transfusions. The goal was to see if the drug could help them go without transfusions for at least 8 weeks. The drug works by helpi…

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. Participants took the drug by mouth once a week for a year to see if it was safe and co…

This early-stage study tested a new drug called JNJ-74856665 in 153 people with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or chronic myelomonocytic leukemia (CMML). The main goals were to find safe doses and check for side effects when given alone or with oth…

This study tested a stem cell transplant from half-matched (haploidentical) family donors for 34 adults with various blood cancers. Patients received a milder chemotherapy and radiation regimen before the transplant. The goal was to see how many patients remained cancer-free 18 m…

This study tested whether the antibiotic levofloxacin can prevent serious fevers and infections in patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are receiving a treatment called azacitidine. The trial enrolled 60 adults and compared those who t…

This study tested a new drug called VIC-1911 added to standard medications to prevent graft-versus-host disease (GVHD) in 16 adults with blood cancers receiving a stem cell transplant. The goal was to find a safe and effective dose that reduces GVHD and relapse. Results are still…

This study tested a drug called RAD001 (everolimus) in 29 people with blood cancers like leukemia, lymphoma, or myelofibrosis that had come back or not responded to treatment. The goal was to find the safest dose and see if it could shrink or control the cancer. The trial combine…

This early-phase trial tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard therapy. The main goal was to find the safest dose and check for s…

This study tested a new type of transplant for people with acute myeloid leukemia or myelodysplastic syndromes who cannot have a standard bone marrow transplant. Instead of using strong drugs to suppress the immune system, doctors gave a small number of stem cells from a partiall…

This study tested whether the drug palifermin could make stem cell transplants safer and reduce chronic graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. Thirty-four adults with blood cancers received palifermin before transplan…

This study looked at a new way to do bone marrow transplants for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Instead of using the standard drug cyclophosphamide after transplant, doctors tested replacing it with another drug call…

This study tested the drug dasatinib in 68 adults with several types of blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control the disease and to check its safety. Participants took dasati…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This early-phase study tested a new oral drug called NTX-301 in 22 adults with blood cancers like acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that had not responded to prior treatments. The main goal was to check safety and find the right dose. Researchers als…

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma, solid tumors, and myelodysplastic syndromes. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps…

This study tested a new way to help people with blood cancers (like leukemia or lymphoma) get into hospice care earlier. Normally, hospice doesn't cover blood transfusions, so patients delay hospice to keep getting them. The study paid for transfusions while patients were on hosp…

This study looked at 1,753 patients needing a stem cell transplant for blood cancers or other serious blood disorders. Researchers compared two strategies: first searching for a matched unrelated donor, then trying an alternative donor if needed, versus going straight to an alter…

This study looked at how the immune system recovers after a stem cell transplant for blood cancers like leukemia. Researchers measured the function of immune cells (T and NK cells) in 61 adult patients over time. The goal was to better understand recovery patterns and help doctor…

This study followed 349 people newly diagnosed with myelodysplastic syndromes (MDS), a group of blood disorders that can lead to leukemia. Researchers used advanced DNA testing to find gene mutations and see how they affected survival and treatment response. The goal was to bette…

This study looked back at medical records of 418 adults with lower-risk myelodysplastic syndromes (MDS) who had not previously received certain anemia treatments. Researchers wanted to see how doctors actually use luspatercept and how patients respond in everyday practice. The go…

This study tested whether a telehealth program could help older patients (60+) with acute myeloid leukemia or myelodysplastic syndrome discuss and document their future medical wishes. Researchers enrolled 36 patients, caregivers, and clinicians to see if the program was easy to …

This study looked at 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers collected blood, bone marrow, skin, and cheek samples to study genetic, epigenetic, and immune features. The goal was to find factors that predict how the …

This study looked at how often people with certain blood cancers or related conditions have an acquired deficiency of an enzyme called pyruvate kinase, which can cause anemia. Researchers took a single blood sample from 18 participants to measure enzyme activity and check for rel…