MYELODYSPLASTIC SYNDROMES

This study tested a low-dose version of the cancer drug ASTX727 in 160 adults with lower-risk myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to find a safer, more effective dosing schedule that improves blood cell counts and reduces the need for blood trans…

This study tested whether replacing a standard transplant drug (cyclophosphamide) with a different drug (bendamustine) could make half-matched bone marrow transplants safer for people with blood cancers like leukemia and lymphoma. About 50 patients took part. The goal was to redu…

This study tested the drug dasatinib in 68 adults with various blood cancers and disorders, including certain leukemias, myelofibrosis, and mastocytosis. The main goal was to see if dasatinib could help control the disease and to check its safety. Researchers measured how many pa…

This study tested whether adding an experimental drug (VIC-1911) to standard medications can prevent graft-versus-host disease (GVHD) and cancer relapse after a stem cell transplant. Sixteen adults with blood cancers like leukemia or lymphoma took part. The goal was to find the b…

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. The goal was to see if taking ONC-201 weekly for a year could help prevent the cancer f…

This early-phase trial tested the safety of combining two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. Participants received the drugs in 21-day cycle…

This study looked at whether covering the cost of blood transfusions would encourage people with blood cancers to enroll in hospice care earlier. Many blood cancer patients need regular transfusions for symptom relief, but hospices often can't afford to provide them. The study of…

This study looked at 1,753 patients with blood cancers or blood disorders who needed a stem cell transplant but lacked a fully matched sibling donor. Researchers compared two strategies: first searching for a matched unrelated donor and then an alternative donor if needed, versus…

This study looked at 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers collected blood, bone marrow, skin, and cheek samples to study genetic and immune factors. The goal was to find patterns that could predict how the disease…