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New drug combo may make Half-Matched bone marrow transplants safer

NCT ID NCT02996773

First seen Nov 11, 2025 · Last updated Jun 16, 2026 · Updated 32 times

Summary

This study looked at a new way to do bone marrow transplants for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Instead of using the standard drug cyclophosphamide after transplant, doctors tested replacing it with another drug called bendamustine to see if it was safe and worked well. About 50 patients took part, and the goal was to reduce side effects like graft-versus-host disease while still helping the new marrow grow.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • The University of Arizona Cancer Center

    Tucson, Arizona, 85724, United States

Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia acute undifferentiated leukemia B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma Burkitt lymphoma chronic myelogenous leukemia, BCR-ABL1 positive follicular lymphoma Hodgkins lymphoma interdigitating dendritic cell sarcoma large B-cell lymphoma leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive lymphoma Lymphoma, B-Cell, Marginal Zone lymphoma, non-Hodgkin, familial mantle cell lymphoma marginal zone lymphoma Mycobacterium avium complex disease myelodysplastic syndrome Myelodysplastic Syndromes non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.