KERATOCONUS

This study tests a new implant made from pig collagen for people with severe keratoconus or post-LASIK ectasia who want to avoid a corneal transplant. The implant is placed inside the cornea to improve eye stability and vision. The study will check if the implant is safe and well…

This study tests a non-FDA-approved treatment called corneal crosslinking (CXL) for people with keratoconus and similar conditions that cause the cornea to thin and bulge, blurring vision. Participants receive vitamin B2 eye drops followed by either 18 or 24 minutes of UVA light …

This study tests an experimental treatment called corneal crosslinking (CXL) for people with Down syndrome who have a condition that makes the front of the eye thin and misshapen, causing blurry vision. The treatment uses vitamin B2 eye drops and ultraviolet light to strengthen t…

This study tests whether small plastic inserts placed in the cornea can reduce vision problems caused by keratoconus, a condition that makes the cornea bulge. The goal is to improve vision and help patients avoid needing a corneal transplant. The study will enroll 25 adults who c…

This study tests a laser procedure called custom corneal cross-linking (CXL) for people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The treatment uses a laser guided by OCT imaging to smooth the cornea and strengthen it. Researchers will…

This study tests an experimental eye drop called GLK-221 for people with keratoconus, a condition where the cornea thins and bulges outward, blurring vision. The trial will enroll 100 adults aged 18 to 55 and compare the eye drop to a placebo over several months. The main goal is…

This study compares two procedures for people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. One group gets a laser vision correction (PRK) plus corneal cross-linking (CXL) to both improve vision and stop the disease from getting worse. The…

This study tests a device that uses ultraviolet light and riboflavin (vitamin B2) drops to stiffen the cornea, the clear front part of the eye. It is for people aged 10 and older with keratoconus or similar conditions that cause the cornea to bulge and thin, leading to blurry vis…

This early study tests a small metal device implanted in the cornea to treat advanced keratoconus, a condition where the eye's front surface bulges and blurs vision. The goal is to flatten the cornea and improve sight, potentially avoiding the need for a corneal transplant. The s…

This study is testing a new imaging tool called Brillouin microscopy to see if it can better diagnose corneal conditions like keratoconus and ectasia. Researchers will scan the corneas of healthy volunteers and patients with these conditions to compare their biomechanical propert…

This study aims to improve how doctors detect and treat irregularly shaped corneas caused by conditions like keratoconus, dry eye, and scars. Researchers will use a special imaging technique called optical coherence tomography (OCT) to create a better classification system and gu…

This study looks at how pain pathways in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye imaging to measure these changes in 60 participants aged 8-35. The goal is to better u…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, for two years. Researchers will track eye shape, thickness, vision, and tear proteins to see how the disease progresses. Some participants will have no treatment (just advice to avoid ey…

This study tests whether a special eye-imaging technology (OCT) can help fit scleral contact lenses better than the current method. About 258 people with conditions like keratoconus or post-surgery corneal irregularities will have two lens fittings—one using standard methods and …

This study follows up to 5,000 people with keratoconus, a condition that makes the cornea thin and bulge. Researchers will use special eye scans to see how the disease starts and changes over time. The goal is to better understand keratoconus, not to test a new treatment.

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like LASIK or corneal crosslinking. Researchers will take detailed images of the eyes of 60 participants—some with kerato…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …