INFECTIONS

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal infections (a cause of meningitis). About 240 people aged 3 to 55 will receive either the new vaccine or a reference vaccine. Researchers will measure immune responses and check for sid…

This study tests whether taking antibiotic pills is as effective as getting them through an IV for treating infected bone fractures that didn't heal properly. About 250 adults with this condition will be randomly assigned to either oral or IV antibiotics for up to 6 weeks after s…

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This study tests whether giving L-Citrulline, a natural supplement, for 28 days can help hospitalized children aged 1 month to 5 years who have fever and are at high risk of serious problems. About 888 children in Mozambique and Ethiopia will receive either the supplement or a pl…

This study tests a wireless, bioelectric bandage called PowerHeal™ on infected wounds. Researchers want to see if it clears infection and helps wounds close better than standard care. About 150 adults with infected traumatic wounds will take part. The bandage is changed regularly…

This study tests whether giving a single 2-gram dose of azithromycin to pregnant women before starting labor induction can lower the chance of infections like chorioamnionitis in mothers and infections in newborns. About 400 women in their third trimester with a singleton pregnan…

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This study tests whether checking vancomycin levels after the first dose and adjusting quickly helps infants with sepsis reach the right drug concentration sooner. About 40 infants under 90 days old will receive model-based dosing and early monitoring. The goal is to improve infe…

This study collects blood samples from 20,000 adults with conditions like infections, heart disease, or kidney issues. Researchers will use these samples to develop and fine-tune new diagnostic tests that can deliver results quickly at the point of care. The goal is to make disea…

This study tests whether an augmented reality system can help doctors guide needles during MRI scans for procedures like biopsies or injections. It involves 25 children and young adults aged 3 to 21. The goal is to see if the system is safe and works reliably, potentially making …

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3300 adults with suspected infections to find patterns that signal sepsis. The goal is to help doctors id…

This study compares two ways to prevent seroma (fluid buildup) after breast removal surgery. Normally, two drains are placed under the skin. Here, doctors use special quilting stitches that attach skin to muscle, and test if one drain works as well as two. 60 women having mastect…

This study looks at whether showering 48 hours after breast reconstruction surgery, while drain tubes are still in place, raises the risk of infection. It also checks how showering affects quality of life. About 100 women having implant-based breast reconstruction will take part.…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow 300 patients and 300 family members over time to understand the genetic causes and health problems linked to the condition. No new t…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review medical records of 350 patients who had this surgery in France between 2017 and 2024. The goal is to find out what factors increase infection risk and how infections affe…

This study aims to reduce deaths from maternal sepsis, a leading cause of death in new mothers in the U.S. Researchers will create and test a safety bundle in four hospitals, involving over 33,000 birthing people. The goal is to see if the bundle helps diagnose and treat sepsis f…

This study tests if a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer common illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengthe…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and looking at conditions like diabetes, high blood pressure, a…

This study follows 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will collect data on pain, daily activities, and strength using standard shoulder scores. The goal is to better understand…

This study measures how much of the antibiotic meropenem-pralubactam gets into the lungs of 16 healthy adults in China. Participants receive four doses of the drug, and researchers check levels in blood and lung fluids. The goal is to understand drug distribution, not to treat an…

This study is creating a personalized immune score to predict severe infections in immunocompromised patients, such as those who have received stem cell or organ transplants. Researchers will measure immune cells and virus-specific responses before or one month after transplant. …

This study looks at a type of bacteria called Bacillus cereus that can cause severe blood infections in premature babies, with a death rate up to 30%. Researchers will use advanced genetic testing to analyze bacteria from 40 infected infants and combine that with medical records …

This project works to improve how doctors diagnose and treat infections in people with heart devices like pacemakers. It brings together teams of specialists to follow best-practice guidelines. The goal is to identify infections faster and start the right treatment sooner. About …

This study looks at whether people with cystic fibrosis can collect sputum (mucus) samples at home and mail them in to detect lung infections as accurately as samples taken in a clinic. With newer treatments reducing mucus production, diagnosing infections has become harder. The …

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study tracks 150 adults getting a HeartMate 3 heart pump to see if the pump's data (like alarms and power changes) can predict problems such as bleeding, infection, or frailty. Researchers will also check if this data relates to quality of life. The goal is to find patterns …