INFECTIONS

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal disease (a serious infection) compared to an existing vaccine. About 240 people aged 3 to 55 will take part. Researchers will check for side effects and measure the immune response.

This study tests whether adding a protein called recombinant human plasma gelsolin to standard care can help people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive either the st…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney problems. Researchers will use these samples to develop and fine-tune new diagnostic tests that can give results quickly at the doctor's office or bedside. The goal is to m…

This study looks at whether a hospital safety checklist can help prevent or catch sepsis (a severe infection) in women during and after childbirth. Sepsis is the second leading cause of maternal death in the U.S. Researchers will compare infection rates before and after the check…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review records of 350 patients who had this surgery in France between 2017 and 2024. The goal is to find out how often infections occur, what causes them, and how they affect re…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict health problems like bleeding, infection, or frailty. Researchers want to understand how pump alarms and readings relate to patients' quality of life and medical events.…

This early-stage trial is testing how much of the antibiotic meropenem-pralubactam gets into the lungs of 16 healthy adults in China. Participants will receive four doses of the drug intravenously, and researchers will measure its levels in blood and lung fluids. The study does n…

This study looks at a dangerous bacteria called Bacillus cereus that can cause severe infections in premature newborns, with death rates up to 30%. Researchers will analyze the DNA of 40 bacterial samples from infected babies to identify which genetic traits make the bacteria mor…

This study looks at how common certain infections are among asylum seekers living in reception centers in Italy. Researchers will test 250 adults who have been in Italy for 2 to 36 months for diseases like tuberculosis, HIV, hepatitis, and parasitic infections. The goal is to bet…

This study follows up to 600 people with or related to someone with Hyper IgE syndrome, a rare immune condition that causes severe skin and lung infections. Researchers aim to learn how genetic changes cause the disease and track health problems over time. Participants receive th…

This study looks at how to improve care for people with infections in their heart devices (like pacemakers). Doctors will work in teams to follow best-practice guidelines, aiming to diagnose infections earlier and start the right treatment faster. About 200 adults with a heart de…

This study aims to collect information from 20,000 people who have had or will have shoulder replacement surgery. Researchers will track their progress for at least 10 years using surveys and X-rays to see how well the shoulder works and how long the replacement lasts. The goal i…