Could a simple supplement save feverish kids in poor countries?
NCT ID NCT06426147
First seen Jan 06, 2026 · Last updated Jun 21, 2026 · Updated 23 times
Summary
This study tests whether giving L-Citrulline, a natural supplement, for 28 days can help hospitalized children aged 1 month to 5 years who have fever and are at high risk of serious problems. About 888 children in Mozambique and Ethiopia will receive either the supplement or a placebo. The goal is to see if it reduces death, organ failure, or other severe outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hararghe Health Research
RECRUITINGHarar, Ethiopia
Contact Email: •••••@•••••
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Hospital Central de Maputo
RECRUITINGMaputo, Mozambique
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-Citrulline (a dietary supplement)
What this could lead to
If it works, this could provide a simple, low-cost supplement to reduce deaths and serious complications in hospitalized children with fever in low-resource settings.
What could go wrong
This is an early-stage trial with no phase designation, and the supplement may not show benefit over placebo. Results may not apply to other settings or populations.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.