INFECTION

This study tests whether patients with serious infections who are at risk of developing sepsis can be safely monitored at home using wearable devices and a smartphone app. About 120 adults will take part, and the goal is to catch early signs of worsening health so they can get he…

This study looks at whether giving copper supplements to people with cirrhosis (scarring of the liver) who have low copper levels can improve liver function and overall health. About 30 adults with cirrhosis and low or borderline copper will take copper or a placebo for a set tim…

This early-stage study tests whether giving patients with chronic granulomatous disease (CGD) their own white blood cells, corrected with mRNA, can temporarily help them fight infections. Up to 25 men aged 18-75 with a specific gene mutation will receive the treatment and be moni…

This study tests a needle-free device (PIVO Pro) to see if it reduces contamination in blood cultures compared to the usual blood draw method. About 1,148 adults in emergency departments who need a blood culture will be randomly assigned to one of the two methods. The goal is to …

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study tests whether giving antibiotics through a small, portable pump over 24 hours is safe and cost-effective for children with serious bacterial infections. About 150 children who are stable enough to be treated at home will receive the pump instead of multiple daily injec…

This study is testing a new knee replacement system called Persona Revision in 380 adults who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. Participants will be followed for 2 years after surgery.

This study is testing whether a new blood test, called Karius Spectrum, can help doctors find the cause of infections faster in people with weakened immune systems. About 2,000 adults with conditions like organ transplants or cancer will be randomly assigned to get either the new…

This study tests a new tool called the POPScore that uses light and vital signs to predict infection in newborns with breathing problems. The goal is to see if it can detect inflammation early, within the first 6 hours after birth. About 93 newborns will take part in this observa…

This study tests a powerful DNA test called metagenomic sequencing on fluid from the eyes of 36 adults with unexplained inflammation. The goal is to find hidden infections that standard tests miss, which could lead to better treatments. Participants give a small sample of eye flu…

This study looks at whether a protein called vasorin can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Researchers will measure vasorin levels in 144 intensive care patients and compare the…

This study tests a program to prevent dangerous bacterial infections after surgery. Researchers will compare different parts of the program to find the best way to stop the spread of germs in operating rooms. About 6,000 people having orthopedic joint or spine surgery will take p…

This study compares two treatment plans for children with complicated urinary tract infections (UTIs): one group gets a single IV antibiotic dose followed by two days of oral antibiotics, while the other gets three daily IV doses. Both groups finish with a total of 7 days of anti…

This study aims to see if an educational program for ICU doctors can reduce the use of antibiotics in intensive care units. The program includes training on current guidelines and feedback on their prescribing habits. Researchers will compare antibiotic use and patient safety in …

This study compares a new type of hospital care, called an Acute Medical Unit, to standard hospital care for older adults with sudden medical illnesses like infections or falls. Researchers want to see if this model reduces time spent in the hospital, improves quality of life, an…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 children aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to use this dat…

This study collects blood and other body fluid samples from 100 adults to verify that laboratory tests measuring drug levels are correct and reliable. Participants may be taking certain medications or none at all. The goal is to improve the accuracy of drug concentration testing,…

This study aims to understand how common antibiotic-resistant bacteria are in the gut of people using PrEP (HIV prevention medication). Researchers will collect samples from 200 HIV-negative adults during routine STI testing. The goal is to gather information that could lead to b…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis or infection in the ICU. The new method adjusts the dose based on the patient's kidney function using doses already available in hospitals. The main goal is to see if doctors and nurs…

This study is looking at whether early signs in the blood can help doctors identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults to see how well these early markers predict death and organ failure within 28…

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than using a single procalcitonin value to decide when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to …

This study enrolls people with known or suspected infections or inflammatory conditions to help doctors learn and improve diagnosis. It is not a treatment trial but a way to gather information and train medical staff. Participants will receive standard medical care and may be ref…