Infection

This study tests whether giving a daily antibiotic (pivmecillinam) to kidney transplant patients at high risk of bloodstream infections can reduce those infections. 150 participants will receive either the antibiotic or a placebo for 5 months after transplant. The goal is to see …

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study looks at whether giving antibiotics over 3 hours works better than the usual 30-minute drip for critically ill children (0-17 years) with severe infections. About 110 kids in intensive care will take part. The goal is to see if the longer infusion clears the infection …

This study tests whether a blood protein called neprilysin can predict if ICU patients with an infection will develop sepsis within 48 hours. Researchers will measure neprilysin and other biomarkers in blood samples from 488 adults at two hospitals. They will also check microcirc…

This study will test a new RT-PCR method to diagnose Rickettsia infection, a tick-borne disease, using routine biopsy samples. Researchers will enroll 800 patients with suspected infection and compare the new test to standard methods. The goal is to see if the test can detect the…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study looks at whether a blood test called procalcitonin can help predict how older adults hospitalized with infections will fare. Researchers will review medical records from 1,000 patients to see if procalcitonin levels at admission are linked to outcomes like death, lengt…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…