HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
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Could a pacemaker ease heart failure symptoms? new study investigates
Disease control Recruiting nowThis study tests whether special pacing therapies can help people with a type of heart failure called HFpEF. About 105 participants will receive pacing and be monitored for changes in heart structure, exercise ability, and daily life over 12 months. The goal is to see if this app…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Medtronic Cardiac Rhythm and Heart Failure • Aim: Disease control
Last updated May 26, 2026 07:27 UTC
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New drug trial aims to ease breathing for heart failure patients
Disease control Recruiting nowThis study tests an investigational drug called TX000045 in people with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure. About 180 adults will receive either the drug or a placebo for 24 weeks. The goal is to see if the drug improves bl…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Tectonic Therapeutic • Aim: Disease control
Last updated May 26, 2026 07:26 UTC
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Heart failure study aims to boost stamina with diabetes drug and nitrate
Disease control Recruiting nowThis study tests whether a diabetes drug (empagliflozin) and a nitrate supplement (potassium nitrate) can help people with a type of heart failure called HFpEF exercise longer. About 53 adults with stable heart failure will take the drugs for a period and then do a treadmill test…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated May 26, 2026 07:24 UTC
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New clinic aims to keep heart failure patients out of the hospital
Disease control Recruiting nowThis study tests a special clinic that helps heart failure patients after they leave the hospital. The clinic provides education, tools like blood pressure monitors, and follow-up phone calls to help patients manage their condition at home. The goal is to reduce hospital readmiss…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Hackensack Meridian Health • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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Pacemaker procedure may cut heart failure deaths in AF patients
Disease control Recruiting nowThis study compares a pacemaker-based procedure (AV node ablation plus physiological pacing) against standard medication in 266 people with permanent atrial fibrillation and heart failure with preserved pumping function. The goal is to see if regularizing the heart rate with paci…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: French Cardiology Society • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New hope for stiff heart failure: device aims to boost blood flow
Disease control Recruiting nowThis study looks at a device called the Coronary Sinus Reducer in 25 people with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD). The device is implanted to improve blood flow to the heart muscle. Researchers will use MRI scans …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 22, 2026 14:02 UTC
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New heart device trial aims to restore energy and reduce hospital stays
Disease control Recruiting nowThis study tests a small implanted device called a CCM that sends gentle signals to strengthen the heart's contractions. It is for 1500 adults with heart failure whose heart still pumps somewhat well (ejection fraction 40-70%). The goal is to see if the device helps them walk far…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Impulse Dynamics • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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New drug could cut heart failure hospitalizations in people with obesity
Disease control Recruiting nowThis study tests a new drug, maridebart cafraglutide, in people with heart failure and obesity. The goal is to see if it reduces heart failure events like hospitalizations and urgent visits, and improves symptoms. About 5,056 adults with a BMI of 30 or higher will take the drug o…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Amgen • Aim: Disease control
Last updated May 22, 2026 13:51 UTC
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New drug HRS-1893 aims to ease stiff heart condition
Disease control Recruiting nowThis study tests a new medicine called HRS-1893 in 48 adults with a type of heart failure where the heart pumps normally but is too stiff. The goal is to see if the drug is safe and can improve heart function and daily life. Participants will receive either the drug or a placebo,…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Shandong Suncadia Medicine Co., Ltd. • Aim: Disease control
Last updated May 19, 2026 12:00 UTC
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Can a smartphone app replace hospital rehab for heart failure patients?
Disease control Recruiting nowThis study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for 100 adults with heart failure. Participants are randomly assigned to either the app-based program or usual care. The goal is to see if the app helps increase physical activity, …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated May 19, 2026 11:47 UTC
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New exercise MRI could spot hidden heart failure
Diagnosis Recruiting nowThis study aims to see if a special exercise MRI can help doctors diagnose a type of heart failure called HFpEF, where the heart pumps well but still doesn't work properly. Researchers will study 400 people, including those with HFpEF, those with shortness of breath from other ca…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated May 26, 2026 07:27 UTC
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Iron shot could help heart failure patients breathe easier
Symptom relief Recruiting nowThis study tests whether a single dose of intravenous iron can improve exercise capacity in people with a type of heart failure (HFpEF) who also have low iron levels. About 66 adults with stable heart failure will receive either the iron infusion or a placebo. The main goal is to…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 26, 2026 07:53 UTC
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Diet study aims to ease heart failure symptoms without drugs
Symptom relief Recruiting nowThis study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and increase exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who also have obesity or type 2 diabetes. About 63 adults will …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2, PHASE3 • Sponsor: University of Leicester • Aim: Symptom relief
Last updated May 26, 2026 07:26 UTC
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Warm legs, stronger heart? new study tests heat therapy for HFpEF
Symptom relief Recruiting nowThis study tests whether daily leg heat therapy can improve exercise ability in people with heart failure with preserved ejection fraction (HFpEF). Participants will wear special trousers that circulate warm water for 90 minutes each day. The goal is to see if this simple home tr…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated May 22, 2026 14:02 UTC
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Pacemaker hope for stiff heart failure patients
Symptom relief Recruiting nowThis study is for people with heart failure with preserved ejection fraction (HFpEF), where the heart is stiff and doesn't fill properly. It tests whether a pacemaker can help the heart beat faster during exercise, improving exercise capacity and quality of life. 30 participants …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia • Aim: Symptom relief
Last updated May 19, 2026 12:00 UTC
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Can a simple supplement boost heart health in veterans?
Symptom relief Recruiting nowThis study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 veterans will take part. The goal is to see if these treatments help…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated May 15, 2026 11:53 UTC
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New scan could reveal hidden heart inflammation in heart failure patients
Knowledge-focused Recruiting nowThis study is testing a special PET scan that uses a tracer called 68Ga-FAPI to look for inflammation in the hearts of people with a type of heart failure called HFpEF. The goal is to see if this scan can help doctors better understand and diagnose this condition. About 35 adults…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 26, 2026 07:59 UTC
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Can fixing breathing boost exercise in heart failure patients?
Knowledge-focused Recruiting nowThis study looks at whether breathing limitations make it harder for people with heart failure and obesity to exercise. Researchers will measure how much oxygen breathing takes and test if breathing a special gas mixture (helium-oxygen) helps with shortness of breath and exercise…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 07:56 UTC
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Special MRI scans aim to unlock mysteries of common heart failure
Knowledge-focused Recruiting nowThis study uses a new type of MRI scan with a special dye to look at how the heart works in people with heart failure with preserved ejection fraction (HFpEF), especially those who also have type 2 diabetes. The goal is to understand why this combination is so harmful. Researcher…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: University of Leicester • Aim: Knowledge-focused
Last updated May 26, 2026 07:24 UTC
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Could a common diabetes drug protect hearts in kidney disease?
Knowledge-focused Recruiting nowThis study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease and early signs of heart failure. Researchers will measure heart strain, oxygen use during exercise, and blood markers. About 60 adults with mode…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 22, 2026 13:51 UTC
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Heart biopsy study aims to unlock secrets of heart failure
Knowledge-focused Recruiting nowThis study looks at heart tissue from people with a type of heart failure called HFpEF. Researchers will take tiny samples of heart muscle during a routine procedure to find changes that could lead to new treatments. About 180 adults with heart failure symptoms will take part.
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC
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Heart failure patients pause Beta-Blockers in new study
Knowledge-focused Recruiting nowThis study involves 30 adults with a type of heart failure called HFpEF. Participants will stop taking their beta-blocker medication for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life to learn more about the effects of stopping …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: UConn Health • Aim: Knowledge-focused
Last updated May 20, 2026 11:57 UTC
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Menopause-Heart link: scientists probe tissue for clues
Knowledge-focused Recruiting nowThis study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 women undergoing heart surgery to understand how the loss of estrogen affects heart energy and blood vessel health. The goal is to uncover bi…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated May 18, 2026 12:06 UTC
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Blood test may spot hidden heart risk in diabetes patients
Knowledge-focused Recruiting nowThis study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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40,000 heart patients monitored in real time
Knowledge-focused Recruiting nowThis study is creating a live registry to track heart failure patients across the Yale New Haven Health System. Researchers will monitor hospitalizations and use of recommended treatments in up to 40,000 participants. The goal is to better understand and improve heart failure car…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Yale University • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Diabetes drug's hidden heart benefit under microscope
Knowledge-focused Recruiting nowThis study looks at how a common diabetes medicine (SGLT2 inhibitor) affects the heart and muscles in people with type 2 diabetes and heart failure. Researchers want to see if the medicine's effect on ketones helps improve energy use in the heart and muscles. About 30 adults will…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: EARLY_PHASE1 • Sponsor: The University of Texas Health Science Center at San Antonio • Aim: Knowledge-focused
Last updated May 11, 2026 20:51 UTC
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Heart failure study aims to personalize care for 1,000 patients
Knowledge-focused Recruiting nowThis study looks at heart failure, a condition where the heart can't pump enough blood, causing shortness of breath and tiredness. Researchers will collect data from 1,000 adults, including heart images and blood tests, to find different types of heart failure. The goal is to hel…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated May 11, 2026 20:39 UTC