HEART FAILURE WITH PRESERVED EJECTION FRACTION
Clinical trials for HEART FAILURE WITH PRESERVED EJECTION FRACTION explained in plain language.
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New shot could ease heart failure in obese patients
Disease control OngoingThis study tests an investigational injection called HRS9531 in 200 obese adults with a type of heart failure (preserved ejection fraction). Participants receive either the drug or a placebo weekly for 52 weeks. The goal is to see if the drug improves heart failure symptoms and h…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Fujian Shengdi Pharmaceutical Co., Ltd. • Aim: Disease control
Last updated May 26, 2026 04:21 UTC
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Could a diabetes pill fix two heart problems at once?
Disease control OngoingThis study tests a drug called enavogliflozin (a type of SGLT2 inhibitor) in 541 adults with heart failure and a leaky tricuspid valve. Participants take the drug or a placebo for 18 months. The goal is to see if the drug reduces heart-related deaths, hospital stays, and valve wo…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE3 • Sponsor: Asan Medical Center • Aim: Disease control
Last updated May 26, 2026 04:18 UTC
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New drug JK07 shows promise in heart failure trial
Disease control OngoingThis study tests a new drug called JK07 in 282 adults aged 18-85 with chronic heart failure. The goal is to see if JK07 can safely improve heart function. Participants are divided into two groups based on their heart's pumping ability. The study is double-blind, meaning neither p…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Salubris Biotherapeutics Inc • Aim: Disease control
Last updated May 26, 2026 04:11 UTC
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New combo drug aims to ease strain on failing hearts with leaky valves
Disease control OngoingThis study looks at whether adding sacubitril-valsartan to standard care helps people with heart failure (where the heart pumps normally but is stiff) and a moderate or worse leaky mitral valve. About 84 adults will take the drug or continue usual care for 6 months. Researchers w…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Ziekenhuis Oost-Limburg • Aim: Disease control
Last updated May 22, 2026 14:02 UTC
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Heart failure drug trial pulled before it even started
Disease control TerminatedThis study was designed to test a drug called CDR132L in people with a type of heart failure where the heart pumps normally but is stiff. The goal was to see if the drug could reverse heart damage. However, the trial was withdrawn before any participants were enrolled, so no resu…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE2 • Sponsor: Cardior Pharmaceuticals GmbH • Aim: Disease control
Last updated May 19, 2026 11:46 UTC
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Fitbits and heart scans: new study seeks clues in heart failure mystery
Knowledge-focused OngoingThis study looks at how information from wearable devices (like activity trackers) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare data from 60 adults—some with HFpEF and some without—using devices, blood tests, a…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated May 26, 2026 03:55 UTC
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Your own personal drug trial: a new way to Fine-Tune heart failure meds
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests a personalized approach called N-of-1 trials to help older adults (65+) with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. Each participant serves as their own experiment, alternating between taking the drug and a placeb…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE4 • Sponsor: Weill Medical College of Cornell University • Aim: Knowledge-focused
Last updated May 22, 2026 14:03 UTC
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New drug combo tested for stiff heart and kidney troubles
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure where the heart pumps well but is stiff (HFpEF), along with chronic kidney disease. Researchers will measure changes in blood and urine markers after giving the…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: PHASE1, PHASE2 • Sponsor: Horng Chen • Aim: Knowledge-focused
Last updated May 20, 2026 11:54 UTC
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Researchers track heart failure patients to uncover key factors affecting outcomes
Knowledge-focused OngoingThis study creates a hospital registry of 240 patients hospitalized for acute decompensated heart failure with preserved ejection fraction (HFpEF). Researchers will collect data on gender, medical history, body composition, and biomarkers to identify factors linked to short- and …
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Sponsor: National Medical Research Center for Therapy and Preventive Medicine • Aim: Knowledge-focused
Last updated May 18, 2026 12:07 UTC
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Study tests if exercise can ease fatigue in heart failure patients
Knowledge-focused OngoingThis study looks at how exercise training might help Veterans with heart failure with preserved ejection fraction (HFpEF) feel less tired and exercise longer. Researchers want to understand the role of nerves in the leg muscles that may limit exercise ability. 45 Veterans with HF…
Matched conditions: HEART FAILURE WITH PRESERVED EJECTION FRACTION
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 11, 2026 20:39 UTC