HEART DISEASES

This study tests whether using an insertable heart monitor (or a wearable patch) to detect atrial fibrillation early can guide treatment and reduce the total time spent in AF after catheter ablation. About 120 people with paroxysmal or persistent AF will be monitored for a year a…

This study tests a new device called the PULSTA valve, which is placed inside the heart through a tube in a blood vessel, avoiding open-heart surgery. It is for 58 people with a leaky or narrowed pulmonary valve, often due to a birth defect. The goal is to see if the valve is saf…

This study tests a temporary heart pump called the Supira System in 71 people with severe coronary artery disease who need a high-risk procedure to open blocked arteries. The pump supports the heart for up to 4 hours during the procedure to prevent dangerous drops in blood pressu…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study compares two types of stents (small mesh tubes) used to open blocked heart arteries in people with severe three-vessel coronary artery disease. About 1,550 participants will receive either the SUPRAFLEX Cruz or SYNERGY stent. The goal is to see which stent is safer and…

This study tests whether a computer-based risk score can identify people more likely to have undiagnosed atrial fibrillation (AF), a heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors will use a remote ECG monitor at home.…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having certain heart surgeries will receive either a long-acting or standard form of the numbing drug bupivacaine. Researchers will tr…

This study looks at whether older adults with a specific type of heart disease (cardiac amyloidosis) feel better when they stop taking a common heart medication called a beta-blocker. Twenty participants will each go through two periods—one on the drug and one off—to compare thei…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study looks at whether giving people a combined genetic and lifestyle risk score for heart disease helps doctors make better decisions. About 1,000 adults with moderate risk will be randomly assigned to receive their score or not. Researchers will track if those who get thei…

This study follows over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to under…

This study tests a personalized approach called N-of-1 to help older adults with a type of heart failure (HFpEF) decide whether to keep taking beta-blockers. Participants will try periods on and off the medication and report their confidence and preferences. The goal is to see if…

This study explores whether specially designed online social networks can improve COVID-19 vaccine attitudes and intentions among at-risk populations, including African American and Latinx communities. Over 4,400 participants in the US will be placed in different online groups an…

This study tests whether a community-led program can help rural adults eat better and exercise more to improve heart health. About 2,420 adults from small towns will work together to identify and overcome local barriers to healthy living. The program aims to spark changes in the …

This study follows over 6,000 people over many years to see if feelings like hostility and other psychological factors are linked to heart disease. Researchers are tracking who develops heart problems and looking for patterns. The goal is to better understand how our minds and em…

This study tests whether the PulsePoint app can increase the number of people who receive CPR or a defibrillator from bystanders before paramedics arrive. About 340 adults who suffer sudden cardiac arrest in public places will be included. Half of the 911 calls will trigger the a…

This study follows over 2,300 South Asian adults (ages 40-84) in the U.S. to uncover why they have high rates of heart disease and stroke, even without traditional risk factors. Researchers measure artery calcium and other markers over several years. The goal is to identify new r…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…