HEART DISEASES

This completed study tested whether combining valsartan and hydrochlorothiazide works better than valsartan alone for people with hypertensive heart disease. 118 adults aged 18-70 took part over 8 weeks. Researchers measured blood pressure, heart changes on ECG, and symptoms to s…

This study tested a drug called tovinontrine in 303 adults with chronic heart failure with preserved ejection fraction. Participants received either the drug or a placebo for 12 weeks. The main goal was to see if tovinontrine could lower a heart stress marker called NT-proBNP mor…

This study looked at the SAPIEN XT heart valve, which is placed through a thin tube (catheter) to fix a failed valve in the heart's right ventricle. Researchers wanted to confirm it is safe and works well. They enrolled 57 people with a narrowed or leaky heart valve conduit. The …

This study tested whether providing medically tailored meals to people with heart failure could improve their diet quality. Sixty participants received heart-healthy meals delivered to their homes for 12 weeks. The main goal was to see if their diet scores improved by the end of …

The HARMONY study tested whether a stress management program designed specifically for African American women could help reduce their risk of heart disease, stroke, and diabetes. The program included exercise, nutrition education, and stress management techniques over several mon…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with severely blocked heart arteries (chronic total occlusions). The balloon was used to open the blockage before placing a stent. The main goal was to see if the device could be safely delivered, inflated…

This study tested a new drug called tovinontrine in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if it safely lowers a key heart stress marker (NT-proBNP) compared to a placebo over 12 weeks. Participants had heart failure symptoms for at…

This study tested whether metoprolol, an FDA-approved heart medication, can reduce heart damage after surgery in people with coronary artery disease. 72 adults aged 50 and older who were not already on beta-blockers took part. The drug was given after anesthesia and during hospit…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time can prevent major heart problems like heart attacks, strokes, or death in people with multiple blocked heart arteries. Over 8,000 adults who had a stent placed were randomly assigne…

This study tested a new automatic tool in a small, portable ultrasound device to measure how well the heart pumps blood. Researchers compared the tool's results to those from heart MRI scans, the gold standard. The goal was to see if the automatic tool gives more consistent readi…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study looked at whether eating soy foods can lower the risk of heart attacks and fatal heart disease in women. Over 135,000 Chinese women aged 40 to 70 took part. Researchers tracked their soy intake and heart health over time to see if soy offers protection.

This study tested a device called preCARDIA that temporarily blocks a large vein in the chest to help patients with sudden, severe heart failure. The goal was to see if it is safe and can help remove excess fluid when standard treatments are not working. The study included 60 adu…

This study looked at people with coronary heart disease to see if silent myocardial ischemia (reduced blood flow to the heart without symptoms) raises the risk of heart problems or death. Researchers followed participants for one to three years. The goal was to understand whether…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study compared how full-fat and fat-free milk and yogurt affect the bacteria in your gut and your risk for heart disease. Researchers studied 37 adults over age 50 who were overweight but otherwise healthy. The goal was to see if the fat content and fermentation of dairy pro…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at how a high-fat, high-sugar Western diet changes immune cells called monocytes in healthy, normal-weight adults aged 20-45. Eight participants ate a controlled Western diet for 8 weeks. Researchers measured specific proteins and genes in the blood to understan…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This study looked at whether a heart ultrasound (TEE) should be used routinely or only when needed during low-risk coronary bypass surgery. Researchers enrolled 40 adults with good heart function to test if such a study is feasible. The goal is to help doctors decide when TEE is …