HEART DISEASES

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump helps the heart pump blood and is designed to be safer and more effective than current options. About 780 adults will take part to see …

This study compares two methods of closing the breastbone after open-heart surgery: rigid plate fixation and traditional wire cerclage. Researchers want to see which technique leads to better bone healing and fewer wound problems. The trial involves 250 adults at high risk for co…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. The goal is to see if more grafts lower the risk of death, stroke, heart attack, or needing another procedure. About 4,300 adults with coronary artery disease wi…

This study aims to find out if using multiple arteries for heart bypass surgery is better than using just one artery in women with coronary artery disease. About 2,300 women will be randomly assigned to one of the two surgical approaches. Researchers will track heart-related even…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or people with high bleeding risk who have had a heart procedure using a drug-coated balloon. About 5…

This study looks at how well two types of heart stents (Synergy XD and Synergy Megatron) work in real-life patients with coronary artery disease. About 2000 adults receiving these stents will be followed to see if they have fewer heart attacks, need repeat procedures, or survive …

This study tests whether people with well-controlled recurrent pericarditis (a painful heart inflammation that keeps coming back) can safely switch from their current combination of medicines to just one drug, KPL-387. About 80 adults whose symptoms are stable will be followed fo…

This study tests whether a mechanical heart pump called HeartMate 3 helps people with advanced heart failure live longer and avoid serious problems like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue with standard medica…

This study is testing a new smartphone-connected ECG device to see if it can accurately detect heart attacks (STEMI and NSTEMI) in people coming to the emergency room with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs. About 1,000 adul…

This study tests two methods of giving the contrast agent Lumason during a heart ultrasound: a slow drip versus a single injection. The goal is to see which approach provides clearer images of the heart's left ventricle in people whose initial ultrasound was unclear. About 106 ad…

This study tests whether the experimental drug acoramidis can prevent or delay heart and nerve damage in people who carry a faulty gene for transthyretin amyloidosis (ATTR) but have no symptoms yet. About 582 adults aged 18 to 75 with a known disease-causing TTR gene variant will…

This study tests a new device (TS-RF system) against a standard needle used to access the left atrium of the heart during treatment for arrhythmia (irregular heartbeat) and mitral stenosis (narrowed heart valve). About 70 adults will be randomly assigned to receive either the new…

This study will have 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help spot heart problems earlier and better understand hea…

This study follows 36 people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to understand how the disease naturally progresses under standard care. No new treatments are given…

This study is testing a digital app called VIRTUES to help people with heart conditions manage their health at home. The app provides personalized recommendations on medications, diet, exercise, and more. Researchers will enroll 2000 participants to use the app for one month and …

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). It aims to understand why some of them have a stroke even while taking blood thinners. Researchers will collect blood samples and heart ultrasound images to find bette…

This study tests whether showing people a bedside ultrasound of their heart in the emergency room helps them understand their risk for heart failure and motivates them to improve diet, exercise, and see a doctor. About 100 adults aged 45+ with high blood pressure, diabetes, or ob…

This study looks at whether giving routine heart ultrasounds to nursing home residents can help catch heart problems early and reduce hospital visits. About 1050 residents will take part. Researchers will track how well the screening works and whether it leads to fewer heart fail…

This study is a registry that collects information on Abbott heart devices used in routine care. It will include up to 2,500 people with various heart conditions who receive these devices. The goal is to confirm the devices are safe and work well in real-world settings, not to te…