HEART DISEASES

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This study compares two types of heart bypass surgery: using one artery graft versus multiple artery grafts. Researchers want to see if using more arteries reduces the chance of death, stroke, heart attack, or the need for another procedure. About 4,300 patients will take part ac…

This study is tracking 2,000 people with coronary artery disease who receive either a Synergy XD or Synergy Megatron stent during a routine procedure to open blocked heart arteries. Researchers want to see how these stents perform in everyday medical practice compared to other dr…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue standard medical …

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study tests if a new drug called KPL-387 can safely replace standard treatments for people with recurrent pericarditis (repeated heart lining inflammation). About 80 adults whose condition is well-controlled on current therapy will switch to KPL-387 alone. Researchers will t…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This study tests whether a less extensive ablation approach, guided by advanced heart mapping, works as well as standard ablation for people with atrial tachycardia after prior heart surgery or atrial fibrillation treatment. About 100 adults will be randomly assigned to one of tw…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, reducing blood backflow. The goal is to see if it improves symptoms, walking ability, and …

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study compares two types of heart bypass surgery in 2,300 women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which approach reduces the risk of heart attac…

This study will give heart ultrasounds to 1050 nursing home residents to see if catching heart problems early reduces flare-ups and unplanned hospital stays. Researchers will also check if the scans are practical and affordable for nursing homes. The goal is to improve heart care…

This study is testing a new smartphone-connected 12-lead ECG device to see if it can accurately diagnose heart attacks (STEMI and NSTEMI) in people with chest pain. Researchers will compare the smartphone ECG readings to standard hospital ECGs in 1000 adults. The goal is to valid…

This study tests two methods of giving a contrast agent called Lumason during heart ultrasound. It compares giving the drug as a slow drip versus a single injection to see which provides clearer images of the heart's left ventricle. The study involves 106 adults whose initial ult…

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This early study tests a small device placed in a heart vein to improve blood flow and reduce chest pain in people with coronary microvascular dysfunction. About 30 adults with persistent symptoms will receive the implant. The goal is to see if the device is safe and can relieve …

This registry is collecting information from 8,000 people undergoing heart or chest surgery. The goal is to see how factors before and during surgery relate to serious complications like death, shock, or infection. By analyzing this data, researchers hope to find ways to improve …

This study aims to describe how a genetic heart condition called PKP2-ACM naturally progresses over time in people who receive standard care. Researchers will monitor heart rhythm, biomarkers, and quality of life in 36 participants aged 12 and older. The goal is to better underst…

This study involves 50 people who need a pacemaker or defibrillator. Researchers want to see if using contrast dye and X-rays alone works as well as using an electrocardiogram (ECG) plus dye and X-rays to place a wire in a specific part of the heart called the Bachmann bundle. Th…

This study aims to understand why people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to improve prevention and care for heart problems in this g…

This study is tracking the safety and performance of special tools (like delivery sets and pushers) used by doctors during heart implant procedures. About 685 people who receive these tools as part of their heart treatment will be observed. The goal is to make sure the tools work…

This study looks at whether showing people a bedside ultrasound of their heart in the emergency room can help them understand their risk for heart failure and motivate them to eat better, exercise, and see a doctor. About 100 adults aged 45 or older with high blood pressure, diab…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study aims to learn why American Indians are at high risk for chronic kidney disease and heart disease. Researchers will follow 500 participants over time, measuring kidney function and tracking heart problems. The goal is to identify key risk factors to improve prevention a…

This study looks at how well people from underrepresented groups (Black or non-White Hispanic) with heart or diabetes conditions can stick with a digital clinical trial done from home. Researchers will track how many participants follow the study plan and stay involved. The goal …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This study looks for new genes and blood markers linked to arrhythmogenic cardiomyopathy, a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1,000 people with the condition or their family members from the US and UK. By collecting medical data…

This study is a registry that collects information on Abbott heart devices used in routine care. It will include up to 2500 people with conditions like holes in the heart or valve disease. The goal is to confirm the devices are safe and work well in everyday practice, not to test…

This study looks at how whole milk and skim milk affect blood sugar and cholesterol in 100 adults who drink at least one cup of dairy milk daily. Participants will switch between drinking only whole milk and only skim milk for set periods, while researchers track changes in their…

This study is testing a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations on topics like blood pressure, cholesterol, and lifestyle changes. Researchers will enroll 2000 participants to …

This study collects blood, tissue, and other biological samples from 10,000 volunteers, including healthy people and those with conditions like cancer, heart disease, and diabetes. The samples are stored in a biobank and shared with researchers to uncover how diseases develop and…

This study tests whether a smartwatch connected to a digital platform can help doctors spot heart rhythm problems like atrial fibrillation early. About 520 adults with heart disease or who recently had a heart procedure will wear a smartwatch and a standard heart monitor. The goa…

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…