GASTRIC CANCER

This study tests a new immunotherapy drug called iparomlimab tolvorlimab (QL1706) given before surgery to people with a specific type of advanced stomach cancer (MSI-H/dMMR). The goal is to see if the drug can shrink or eliminate the tumor, making surgery more effective. About 30…

This study tests whether adding the experimental drug TST001 to standard chemotherapy and immunotherapy can help people with advanced stomach or gastroesophageal junction cancer live longer without their disease getting worse. About 820 adults with a specific tumor marker (Claudi…

This study tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) plus chemotherapy for people with advanced stomach or gastroesophageal junction cancer whose first treatment stopped working or caused side effects. The goal is to see if this new combo can s…

This study tests whether adding two drugs (adebrelimab and apatinib) to standard chemotherapy (SOX) before surgery can shrink tumors more effectively in people with locally advanced stomach cancer. About 118 adults aged 18-75 with HER2-negative stomach cancer that cannot be remov…

This study tests a new drug called BHB810 in adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. The drug is given as an IV infusion every two weeks. The main goals are to check safety, find the best dose, and see if it …

This study looks at whether adding beta-blockers (a type of blood pressure medicine) to standard immunotherapy before surgery can help shrink tumors in people with locally advanced stomach cancer who also have high blood pressure. About 33 participants will receive the combinatio…

This study tests whether adding the drug ivonescimab to standard chemotherapy (SOX) can better shrink or eliminate tumors in people with locally advanced stomach or gastroesophageal junction cancer. About 154 participants will receive either the combination or chemotherapy alone …

This study tests giving a short course of radiation along with chemotherapy before surgery for early-stage gastric cancer. The goal is to see if this combination leads to a higher rate of complete tumor disappearance compared to standard treatment. About 20 adults with newly diag…

This study tests a new drug called BL-M05D1 in people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2) and has stopped responding to initial treatment. About 438 adults will be randomly assigned to receive either BL-M05D1 or a standa…

This study aims to see if combining a special PET scan (18F-FAPI) with detailed MRI can improve how doctors diagnose and predict outcomes for gastric cancer. About 230 people with suspected or confirmed gastric cancer will receive both scans. The goal is to measure how accurate t…

This study tests a new fluorescent dye that makes stomach cancer cells glow, helping surgeons see exactly where the tumor ends during surgery. The dye is given to removed stomach tissue in a lab setup that mimics blood flow. Researchers will check if the dye's glow matches the ca…

This study tests a special PET scan that looks for a protein called Claudin18.2 on pancreatic and stomach cancer cells. The goal is to see if this scan can accurately find the protein, helping doctors choose the right targeted treatment for each patient. About 64 adults with thes…

This study compares a newer robotic surgery with fewer incisions to the standard laparoscopic surgery for people with early-stage stomach cancer. About 538 adults aged 20 to 80 will be randomly assigned to one of the two procedures. The main goal is to see if the robotic approach…

This study tests two methods to control pain after keyhole stomach surgery for cancer. One group gets a standard ultrasound-guided nerve block, while the other gets a special gel applied directly to the surgical site that slowly releases pain medicine. The goal is to see which ap…

This study tests whether a low dose of olanzapine, a drug often used for nausea, can help people with stomach cancer maintain their weight and appetite while receiving chemotherapy before surgery. About 26 participants will be randomly assigned to receive either olanzapine plus s…

This study tests whether a sedative called remimazolam can lower the chance of confusion (delirium) after stomach cancer surgery in people aged 65 and older. Half of the 170 participants will get remimazolam, the other half standard sedatives. The goal is to see if remimazolam le…

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had surgery to remove their cancer will give blood samples over 9 months. The goal is to see how of…

This study looks at whether a simple blood test that detects tumor DNA can help doctors decide on the best treatment after surgery for people with stage III or IVA stomach or gastroesophageal junction cancer. About 32 participants will have their blood tested at several time poin…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how doct…