ESOPHAGEAL CANCER

This study looked at 387 people with esophageal cancer to compare two chemotherapy drugs, nab-paclitaxel and paclitaxel, given before surgery. The goal was to see which drug helps shrink tumors more effectively. Researchers used past medical records to analyze the results, findin…

This study tested a combination of three drugs (afuresertib, sintilimab, and chemotherapy) in 22 adults with solid tumors like lung, cervical, or stomach cancer that had stopped responding to prior immunotherapy. The goal was to find the safest dose and see if the combo could shr…

This study tested a combination of chemotherapy (CAPOX) and two targeted antibodies (trastuzumab and bevacizumab) in 37 adults with HER2-positive metastatic stomach or esophageal cancer. The goal was to see how well the treatment shrank tumors and how safe it was. Results showed …

This study tested a two-step surgical approach for 22 people with esophageal cancer who had hardened arteries, which raises the risk of a dangerous leak after standard surgery. About two weeks before the main tumor-removal surgery, patients had a key blood vessel temporarily bloc…

This study tested a type of internal radiation called high-dose brachytherapy in 43 people with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver a high dose directly to the tumor. P…

This study tested a new computer-based tool to help doctors adjust chemotherapy doses for people with cancers of the digestive system (like colorectal or stomach cancer). The goal was to reduce unplanned delays in treatment while keeping the dose strong enough to fight the cancer…

This study tested whether adding two immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy could help people with advanced esophageal cancer that cannot be removed by surgery. About 461 participants received either the immunotherapy combo plus chemo or a pla…

This study tested a new treatment for people with advanced gastrointestinal cancers that had spread and stopped responding to standard therapies. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a gene called CISH that slows down the immune …

This early-phase study tested a new treatment for people with esophageal cancer that has spread to other parts of the body. The approach combined a type of internal radiation (brachytherapy) with the immunotherapy drug pembrolizumab. The goal was to see if this combination is saf…

This study compared two surgical methods for esophageal cancer: open surgery and laparoscopically-assisted (keyhole) surgery. The goal was to see if the keyhole approach reduces serious complications within 30 days after the operation. 207 patients with esophageal cancer took par…

This study looked at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen through the nose) can reduce the risk of low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. The trial involved 80 adults …

This study looked at whether a program to improve physical fitness, nutrition, and sleep before surgery is possible for older adults with esophageal cancer. Fifteen patients aged 65 and older took part after finishing chemotherapy or radiation. The goal was to see if patients wou…

This completed study looked at the genetics of esophageal and stomach cancers, which are common causes of cancer death worldwide. Researchers collected DNA samples from over 7,700 people, including cancer patients and healthy individuals from high- and low-risk areas in China. Th…

This study tested a new imaging technique to see a protein called PD-L1 in esophageal cancer tumors. PD-L1 helps doctors decide if immunotherapy might work, but current tests are not always accurate. Researchers gave 21 patients a special fluorescent dye that attaches to PD-L1, t…

This study followed over 2,100 people who had surgery for esophageal cancer. The goal was to see how long they lived after their operation. The research did not test a new treatment but instead collected information to better understand patient outcomes.

This study looked at 159 people with advanced colorectal, pancreatic, biliary, or esophageal cancers to see if simple blood tests (tumor markers and liquid biopsies) and patient-reported symptoms could predict whether the cancer would get worse. Researchers compared changes in th…

This study aimed to understand why esophageal cancer is so common in Iran's Golestan Province. Researchers followed over 50,000 adults aged 40 to 75, collecting lifestyle information and biological samples. The goal was to identify risk factors like diet, hot tea, tobacco, and ge…

This study looked at 272 people with esophageal cancer to compare two types of minimally invasive surgery: Ivor-Lewis and McKeown. The goal was to see which approach leads to fewer complications and better recovery. Both surgeries are done with small incisions and a camera, but t…

This study follows over 32,900 adults from Linxian, China, a region with very high rates of esophageal and stomach cancer. Researchers are tracking cancer cases and deaths years after participants took vitamin and mineral supplements in the 1980s. The goal is to see if the earlie…

This study looked at whether using MRI scans helps doctors outline esophageal tumors more consistently for radiation therapy. 21 patients with advanced esophageal cancer had MRI scans in addition to standard CT and PET/CT scans. Five radiation oncologists independently outlined t…

This study looked at 100 people with esophageal cancer to see if a very narrow esophagus (stricture) caused by the tumor is linked to more advanced cancer. Doctors used an endoscopic ultrasound to stage the cancer and checked if they could pass the scope through the narrowed area…

This study tested whether AI-assisted software can help doctors outline organs at risk during radiation therapy planning for lung, breast, and esophageal cancers. 500 adults scheduled for chest radiation had their CT scans contoured manually, by AI alone, and by AI with manual tw…

This study analyzed tumor and blood samples from 160 people with esophageal or rectal cancer to find genetic markers that predict how well they respond to chemoradiotherapy given before surgery. The goal was to identify which patients are most likely to benefit from this treatmen…

This study looked at whether adding pictures and stories to alcohol warning labels makes people pay more attention and feel more at risk for cancers like mouth, throat, and voice box cancer. Over 1,000 adults who drink regularly took part. They viewed different warning labels, an…