Which chemo works better for esophageal cancer? study compares two common drugs
NCT ID NCT07549269
First seen Jun 26, 2026 · Last updated Aug 25, 2026 · Updated 3 times
Summary
This study looked back at 387 patients with esophageal cancer to compare two chemotherapy drugs, nab-paclitaxel and paclitaxel, given before surgery. The goal was to see which drug leads to better outcomes like complete cancer removal. The study is completed, but results are not yet published.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nab-paclitaxel and paclitaxel (chemotherapy drugs)
- What this could lead to
- If one drug proves better, it could guide doctors to choose the more effective chemotherapy for esophageal cancer patients before surgery.
- What could go wrong
- This is a retrospective study, not a controlled trial, so results may be less reliable. It also does not test a new treatment, just compares existing ones.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
387 people
The number who actually took part.
- Started
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Apr 2026
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This retrospective study included 1877 ESCC patients who underwent esophagectomy at West China Hospital of Sichuan University and two other centers between June 2019 and December 2024. After screening, 387 eligible patients were included.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Histologically confirmed diagnosis of esophageal squamous cell carcinoma (ESCC). 2. Patients with resectable or potentially resectable disease based on baseline clinical assessment. Exclusion Criteria: 1. Presence of any untreated malignancy within the past five years, except fully treated cervical carcinoma in situ or basal cell carcinoma/squamous cell skin cancer. 2. Receipt of other neoadjuvant treatments, including chemotherapy, chemoradiotherapy, or chemoradiotherapy combined with immunotherapy. Incomplete medical records. 3. Refusal to participate in follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mianzhu People's Hospital(West China Mianzhu Hospital, Sichuan University)
Mianzhu, Sichuan, 861916, China
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Suining Central Hospital
Suining, Sichuan, China
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West China Hospital
Chengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Antibody-Drug conjugate targets advanced esophageal cancer after standard treatments fail
- Can a drug combo stop esophageal cancer from returning after surgery?
- Blood proteins may predict who beats esophageal cancer with chemoradiation
- Experimental drug put to the test against Hard-to-Treat GI cancers
- Can a drug combo shrink esophageal tumors before surgery?
- New Antibody-Drug conjugate put to the test against Hard-to-Treat cancers