ESOPHAGEAL CANCER

This study is for people with esophageal cancer that has spread to a few other parts of the body. It tests whether adding a special high-dose radiation treatment (SBRT) to standard chemotherapy and immunotherapy can help control the disease longer. About 22 adults will take part.…

This study tests a new robotic surgery system that lets doctors operate remotely on patients with colorectal, esophageal, liver, or cervical cancer. About 98 adults aged 18 to 80 will have their surgeries assisted by this system. The main goal is to see how often the surgery can …

This study tests a new drug called QL1706 combined with chemotherapy for people with a type of esophageal cancer that is hard to remove completely with surgery. The goal is to shrink the tumor before surgery and then continue treatment afterward to improve long-term outcomes. Abo…

This early-stage trial tests a new approach: injecting a virus that carries a human gene (endostatin) directly into tumors, along with an immunotherapy drug. The goal is to see if this combination is safe and can shrink tumors in people with advanced head and neck cancer or esoph…

This study tests whether using a blood test to detect leftover cancer DNA can help decide who needs extra chemotherapy after esophageal cancer surgery. About 172 adults with stage 2-3 esophageal cancer will be randomly assigned to either standard follow-up or chemotherapy plus an…

This study tests a new surgical technique for people with esophageal cancer. The method uses a special dye to check blood flow to the stomach, then wraps the surgical connection with a piece of the patient's own stomach lining to prevent leaks. About 73 adults will take part to s…

This phase 3 trial tests whether the drug toripalimab, given after surgery, can help prevent esophageal cancer from returning in high-risk patients. About 435 adults who had surgery after chemo-immunotherapy will either receive toripalimab or just be watched. The main goal is to …

This early-phase trial tests the safety of a new drug, IM-1617, in about 175 adults with advanced solid tumors (colorectal, lung, breast, stomach, esophageal, or other cancers that have spread or can't be removed by surgery). The study first finds a safe dose, then checks how wel…

This study tests whether freezing cancerous tissue with liquid nitrogen before chemotherapy can improve outcomes for people with advanced esophageal cancer. About 40 adults will be randomly assigned to receive either the freezing treatment plus chemo or chemo alone. The freezing …

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests whether a special dye called indocyanine green (ICG) can help surgeons find cancer that has spread to nearby lymph nodes during esophageal cancer surgery. About 144 adults with esophageal squamous cell cancer will receive the dye around their tumor, and surgeons …

This study tests a symptom management program for 252 people recovering from esophageal cancer surgery. The program uses patient feedback to guide care and aims to reduce complications, hospital readmissions, and symptom burden. Participants will use a smartphone app to report sy…

This study tests whether a dye called indocyanine green, given before surgery, can help surgeons see and protect the recurrent laryngeal nerve during esophageal cancer removal. About 144 adults with esophageal cancer will be randomly assigned to get the dye or standard surgery. T…

This early-stage trial tests a new robotic surgery method for esophageal cancer that avoids cuts between the ribs, which may cause less chest pain and faster recovery. About 31 patients will be randomly assigned to either the new approach or standard surgery. The main goals are t…

This study compares two ways to manage pain after minimally invasive surgery for esophageal cancer: a paravertebral catheter versus the standard epidural. The goal is to see if the paravertebral approach provides similar or better recovery quality by day three. About 506 adults h…

This study aims to see if a specific type of immune cell (called Tpex) found in cancer-free lymph nodes can predict whether esophageal cancer will completely disappear after immunotherapy given before surgery. Researchers will compare this method to the current standard test (PD-…

This observational study aims to see if a specific type of immune cell (Tpex) found in cancer-free lymph nodes can predict how well PD-1 inhibitors work for people with advanced or recurrent esophageal cancer. Researchers will follow 158 participants to compare survival times bas…

This study aims to develop an artificial intelligence system that helps doctors choose the best treatment for each person with esophageal cancer. Researchers will collect data from 7,000 patients, including medical images and tissue samples, to train the AI. The goal is to predic…

This early-phase study tests a new imaging method called fluorescence endoscopy to see if certain proteins (PD-1 and PD-L1) are present in esophageal cancer. About 15 participants will receive two 'glow-in-the-dark' tracers before a routine endoscopic exam. The goal is to learn w…