CORONARY ARTERIAL DISEASE (CAD)

This study tests a new approach for opening blocked heart arteries using a special dissolvable scaffold (bioresorbable scaffold) instead of a permanent metal stent. The procedure includes precise imaging and specific steps to ensure the scaffold is placed correctly. About 117 adu…

This study is testing a special balloon coated with a drug (sirolimus) to treat blocked heart arteries. About 1,100 adults with coronary artery disease will receive this balloon treatment during a standard procedure. The goal is to see if it safely opens blockages and keeps arter…

This study tests whether taking algae supplements (spirulina or seaweed) for 20 weeks can improve heart health markers and gut bacteria in 150 adults aged 50+ with conditions like heart disease, diabetes, or kidney disease. Participants are randomly assigned to receive algae or a…

This study tests a new device that freezes high-risk plaque in heart arteries to reduce the risk of future heart attacks. About 30 adults with stable angina or acute coronary syndrome will receive the freezing treatment during a planned procedure. Doctors will use special imaging…

This study is testing a new device called the Supira System in 45 people with heart failure and severe coronary artery disease who need a high-risk heart procedure. The device helps pump blood during and after the procedure, potentially reducing complications. The goal is to see …

This study tests whether leaving a special chest tube in place for up to three days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart operations will be randomly assigned to get the…

This study tests whether using a genetic score (ABCD-GENE) to guide reducing blood thinners after heart stent placement works better than the usual approach. About 90 adults who have had a stent and are on two blood thinners will be randomly assigned to either a gene-guided or st…

This study compares two methods—orbital atherectomy and intravascular lithotripsy—for treating hard calcium deposits in heart arteries. About 50 adults with coronary artery disease will be randomly assigned to one of the two techniques before getting a stent. The goal is to see w…

This study tests a drug called orticumab in 240 people who have had a heart attack and still have high inflammation in their heart arteries. The goal is to see if orticumab can lower this inflammation better than a placebo over 6 months. Participants will have CT scans to measure…

This study tests whether placing a stent in artery plaques that are vulnerable but not yet blocking blood flow can prevent future heart attacks or chest pain. About 2,190 people with coronary artery disease will either get a stent plus intensive drug therapy or drugs alone. The g…

This study tests whether a drug-coated balloon can be a safe and effective alternative to stents for people with coronary artery disease. About 1,600 participants will be randomly assigned to receive either the balloon or standard stent treatment. The goal is to see if the balloo…

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower-dose one (prasugrel) can better control blood clotting in heart patients who have both high bleeding and high clotting risks after getting a stent. About 40 adults who have been on dual b…

This study looks at whether adjusting the dose of the blood thinner cangrelor based on individual test results can better control clotting risk in people with coronary artery disease who need to pause their regular medication before surgery. About 50 adults will receive either a …

This study looks at whether using both a drug-coated balloon and a drug-eluting stent together is better than using just one of them to open blocked heart arteries. It involves 120 adults with diabetes and coronary artery disease who have not had a stent before. Participants are …

This study compares two types of drug-coated balloons used to open blocked heart arteries, specifically at branch points (bifurcations). About 250 adults with coronary artery disease will receive either a sirolimus-coated or a paclitaxel-coated balloon. The goal is to see if the …

This early study tests a new device that uses sound waves to break up hard calcium deposits in heart arteries, making it easier to place a stent. Up to 15 adults with severe coronary artery disease will receive the treatment. The goal is to see if the device is safe and helps ope…

This study tests a special catheter that sends shockwaves to break up hard calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and helps open blocked arterie…

This study tests whether a lower dose of the blood thinner prasugrel, taken without aspirin, is safe and effective for people who have had a heart stent placed. About 300 adults with acute or chronic coronary artery disease will receive 5 mg of prasugrel daily for 6 to 12 months.…

This study tests whether a super high-pressure balloon or a special shockwave device (intravascular lithotripsy) works better to crack open severely calcified coronary arteries before placing a stent. About 78 adults with hardened heart arteries will be randomly assigned to one o…

This study looks at whether measuring how well the left side of the heart pumps in sync can help doctors diagnose microvascular dysfunction—a condition where tiny heart blood vessels don't work properly. Researchers will use a special imaging test (SPECT) to check heart timing in…

This study tests whether adding special breathing muscle exercises to a standard cardiac rehab program helps people with narrowed heart arteries recover better. About 72 adults who had a heart procedure will participate. The goal is to see if this extra training improves exercise…

This study tests whether applying shockwaves to the leg wound after heart bypass surgery can reduce healing problems. About 120 adults needing bypass with vein grafts will receive either shockwave treatment or a sham procedure. The goal is to see if this simple addition lowers in…

This study tests two traditional Chinese medicines—Compound Danshen Dripping Pill and Qishen Yiqi Dripping Pill—in people aged 75 to 90 with coronary heart disease who still have chest pain or discomfort despite standard treatments. The goal is to see if these herbal remedies can…

This study looks at whether artificial intelligence (AI) can detect a type of heart attack that standard tests often miss. Researchers will observe 1,500 adults with suspected acute coronary syndrome but no clear signs on their ECG. The goal is to see if AI can identify these hid…

This study looks at a newer, less invasive heart bypass surgery that avoids touching the main artery (aorta) compared to the standard open-chest method. Researchers want to see if the new technique is just as safe and effective at keeping bypass grafts open. About 260 people need…

This study is looking at 1500 adults with coronary artery disease to find out which factors—like genetics, heart activity, blood markers, and lifestyle—best predict sudden cardiac arrest or death. Researchers hope to identify high-risk patients who could benefit from implantable …

This study reviews medical records of 1,500 adults who had a coronary angioplasty with a drug-eluting balloon between 2010 and 2025. Researchers will track major heart problems like heart attack, stroke, or need for another procedure. The goal is to understand how well these ball…

This study looks at how feeling empowered and having a sense of purpose (called 'ikigai') relate to each other in people with stable coronary artery disease. Researchers will survey 300 adults to understand these connections and help nurses provide better, more personalized care.…

This study follows 1500 adults with coronary artery disease who receive a drug-coated balloon instead of a stent during a heart procedure. Researchers want to see how successful the balloon is right away and over time, including risks like death, heart attack, or needing another …