CELIAC DISEASE

This study tests a drug called DONQ52 in people with active celiac disease who still have gut damage and symptoms even after trying a gluten-free diet. The goal is to see if the drug can heal the small intestine and reduce symptoms like belly pain and bloating. About 92 adults wi…

This study tests whether taking omega-3 supplements (2.4 grams daily for 3 months) can reduce inflammation and improve gut healing in 40 adults newly diagnosed with celiac disease, who are also starting a gluten-free diet. Half the participants get omega-3s, half get a placebo, a…

This study tests an experimental drug called FB102 in 100 adults with well-controlled celiac disease who follow a strict gluten-free diet. Participants will receive either the drug or a placebo and then undergo a controlled gluten challenge to see if FB102 can reduce intestinal d…

This study will collect images and videos from 10,000 patients who undergo capsule endoscopy (a pill-sized camera that takes pictures of the digestive tract). Researchers will use this data to train artificial intelligence to detect bowel diseases like Crohn's, celiac disease, an…

This early-stage study tests the safety of a single dose of HB-2121 in 20 adults with suspected celiac disease. Participants take the drug before a standard endoscopy, and researchers monitor side effects and how the drug interacts with the small intestine over 30 days. The goal …

This study is developing an artificial intelligence (AI) system to detect damage in the small bowel caused by celiac disease and similar conditions. Researchers will train the AI using past endoscopy images and then test it in a new group of 380 adult patients. The goal is to see…

This study tests whether the drug ZED1227 can reduce ongoing celiac disease symptoms in people who already follow a strict gluten-free diet. About 356 adults with confirmed celiac disease will receive either the drug or a placebo. The goal is to see if the drug improves stomach p…

This early-stage study tests whether a new drug called VTP-1000 is safe for adults with celiac disease. About 45 participants will receive either the drug or a placebo. Some will also eat gluten to see how the drug affects their immune response. The goal is to find a treatment th…

This study tests whether a special toothpaste and mousse can reduce tooth sensitivity and enamel damage in adults with celiac disease. Forty participants will use either the toothpaste alone or with an added mousse for six months. The goal is to see if the mousse provides extra r…

This study tests whether a mobile app, backed by a nurse navigator, can help adults newly diagnosed with celiac disease feel better day-to-day. Sixty participants will either use the app for six months or receive standard education. The goal is to see if the app improves quality …

This study looks at how people with celiac disease react to gluten in liquid form (a shake) versus solid form (a cookie). Researchers want to see if one causes a stronger immune response. Thirty adults who follow a strict gluten-free diet will take part, giving blood samples and …

This study aims to uncover the genetic and biological differences between various forms of celiac disease and a related skin condition called dermatitis herpetiformis. Researchers will analyze blood, gut, and skin samples from 3,500 participants, including patients and their heal…

This study looks at how gluten affects the gut in people with celiac disease, focusing on tissue damage and healing. Researchers will study 220 adults, including those on a gluten-free diet, those with symptoms not on the diet, and healthy controls. The goal is to better understa…

This study looks at how the immune system of children with celiac disease reacts to tiny, controlled amounts of gluten. Kids on a strict gluten-free diet will get either a placebo, a small gluten dose, or a larger one for three days. Researchers will analyze blood, stool, and uri…

This study looks at why the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells from 200 adults to understand how these cells cause problems and sometimes lead to cancer. The goal is to learn more abo…

This study collects health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a phone app to share symptoms, wearables data, and lifestyle details. The goal is to help researchers better understand these illness…

This study follows 500 infants who have a parent or sibling with celiac disease. Researchers collect stool and blood samples over time to track gut bacteria, gut health, and immune responses. The goal is to identify early signs that may predict who will develop celiac disease, wh…

This study is testing whether it's possible to screen all children for type 1 diabetes and celiac disease during regular doctor visits. Researchers will enroll up to 33,000 children from birth to age 6 at Sanford Health clinics. The goal is to see if parents will agree to screeni…

This study collects tissue and blood samples from 300 people with autoimmune diseases like ulcerative colitis, multiple sclerosis, and Crohn's disease. Researchers will identify which T-cells are active in inflamed tissues and find their targets. The goal is to discover new targe…

This study aims to find out how many relatives of people with celiac disease have wheat sensitivity or other gut problems like irritable bowel syndrome. Researchers will ask 600 adult relatives to follow a wheat-free diet for 6 weeks and report their symptoms. The goal is to bett…

This study is collecting tissue samples from 300 people to improve how doctors diagnose small-bowel diseases like celiac disease. Researchers will use advanced tools like AI and genetic analysis to create more accurate reference values and diagnostic methods. The goal is to bette…