BIPOLAR DEPRESSION

This study looks at whether giving a more intensive medication plan earlier can help people with schizophrenia, major depression, or bipolar depression who didn't get better with their first treatment. About 1,250 adults will be randomly assigned to either the usual next-step tre…

This study tests whether starting a stronger, six-week medication plan early can help people with bipolar depression whose first treatment didn't work. About 418 adults will either get the intensified treatment or continue usual care. The goal is to see if early action leads to b…

This study tests whether a nutrition program focused on healthy eating patterns can lower cardiovascular risk in 88 adults with bipolar disorder. Participants will either receive usual care or add dietary counseling sessions with a dietitian. The goal is to see if better food cho…

This study tests if deep brain stimulation (DBS) can help people with severe bipolar depression that hasn't improved with other treatments. DBS uses surgically implanted electrodes to send electrical pulses to specific brain areas. The goal is to improve mood and daily function, …

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can reduce depression symptoms in adolescents with bipolar disorder. One hundred teens will receive either real or sham stimulation over two weeks, alongside their usual care. Researchers will also…

This study tests a new medication called azetukalner for people with bipolar I or II disorder who are currently in a depressive episode. Researchers want to see if it reduces depression symptoms better than a placebo over 6 weeks. The trial involves 400 adults aged 18 to 74 and i…

This study tests whether a strict high-fat, low-carbohydrate (ketogenic) diet can help ease depression in people with bipolar disorder. Thirty adults aged 18 to 50 will follow the diet for 8 weeks while researchers track mood changes and heart health. The goal is to see if this d…

This study tests whether limiting eating to a 10-hour window each day is a safe and practical addition to standard treatment for bipolar disorder. Forty adults with bipolar I or II who are currently experiencing depression will either receive nutritional counseling alone or combi…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can help ease depression in people with bipolar disorder. About 100 adults with bipolar depression will receive either real or fake dTMS alongside their usual …

This study tests if a type of brain stimulation called iTBS can reduce depression symptoms in people with bipolar disorder that hasn't improved with other treatments. About 124 adults will receive either real or fake (sham) stimulation daily for 30 days. Researchers will track mo…

This study follows 1,000 adults with hard-to-treat depression or OCD who receive advanced treatments like brain stimulation or ketamine. Researchers will collect data from brain scans, cognitive tests, and voice recordings to find markers that predict which treatment works best f…

This study looks at whether changes in RNA editing can help predict how well people with depression respond to treatment. Researchers at Mayo Clinic will follow 120 adults with unipolar or bipolar depression to track RNA patterns and depression scores. The goal is to better under…