BIPOLAR DEPRESSION
Clinical trials for BIPOLAR DEPRESSION explained in plain language.
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New hope for bipolar depression: major trial tests experimental medication
Disease control CompletedThis study tested whether a medication called ITI-007 (Lumateperone) helps reduce depression symptoms in people with bipolar disorder. Researchers enrolled 554 adults with bipolar I or II disorder who were experiencing a depressive episode. Participants received either the medica…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE3 • Sponsor: Intra-Cellular Therapies, Inc. • Aim: Disease control
Last updated Apr 03, 2026 14:43 UTC
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Ketamine shows promise for stubborn bipolar depression
Disease control CompletedThis study tested whether regular ketamine infusions could help maintain relief from severe bipolar depression in people who initially responded to the treatment. Forty-one adults with treatment-resistant bipolar depression received flexible-dose ketamine infusions every 2-4 week…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Ketamine shows promise for stubborn bipolar depression in new trial
Disease control CompletedThis study tested whether repeated low-dose ketamine infusions could help people with treatment-resistant bipolar depression. 71 participants who hadn't responded to standard medications received either ketamine or a sedative placebo over two weeks. Researchers measured changes i…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Scientists scan brains to see how ketamine fights depression
Symptom relief CompletedThis study aimed to understand how ketamine infusions might help people with bipolar depression that hasn't responded to other treatments. Researchers gave 20 participants a series of ketamine infusions and used brain scans (fMRI) before and after treatment to see how brain conne…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Brian Barnett • Aim: Symptom relief
Last updated Apr 03, 2026 22:41 UTC
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Natural compound tested as add-on treatment for bipolar depression
Symptom relief CompletedThis study tested whether adding a supplement called palmitoylethanolamide (PEA) could help reduce depression symptoms in people with bipolar disorder. Thirty-four participants who were already taking standard mood-stabilizing medications received either PEA or a placebo for seve…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Symptom relief
Last updated Apr 03, 2026 22:41 UTC