BIPOLAR DEPRESSION

This study looked at whether repeated ketamine infusions can help people with bipolar depression who did not get better with other treatments. 41 adults who already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if th…

This small study tested whether low-dose interleukin-2 (IL-2) could help people with bipolar disorder who are currently depressed. Fourteen participants already on mood stabilizers received the drug to see if it would improve their immune system's regulatory cells and ease depres…

This study tested a new, non-invasive treatment for people with depression, anxiety, bipolar disorder, or PTSD. Researchers used low-intensity focused ultrasound to gently stimulate a brain region called the amygdala over 15 sessions. The goal was to see if this approach is safe …

This study tested whether a natural compound called palmitoylethanolamide (PEA) can help reduce depression in people with bipolar disorder. 34 adults who were already taking a mood stabilizer took PEA or a placebo. Researchers measured changes in depression scores and looked for …

This study tested a new medication called ITI-007 (Lumateperone) to see if it can safely ease depression in people with bipolar I or II disorder. About 550 adults experiencing a major depressive episode took either the drug or a placebo for 6 weeks. The main goal was to measure c…

This study tested whether repeated doses of intravenous ketamine can safely and effectively reduce depression in people with bipolar disorder who haven't responded to other treatments. 71 adults with bipolar I or II and current major depression received four ketamine infusions or…

This study looked at how ketamine changes brain connections in people with bipolar depression that hasn't improved with other treatments. Twenty adults received ketamine and had brain scans before and after. The goal was to see if brain activity patterns could predict who gets be…