BIPOLAR DEPRESSION
Clinical trials for BIPOLAR DEPRESSION explained in plain language.
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Gut health may hold key to bipolar relapse prevention
Disease control OngoingThis study tests whether taking a daily probiotic supplement can help people with bipolar depression stay well after a hospital stay. Researchers will compare the probiotic to a placebo in 80 adults to see if it reduces the chance of needing to go back to the hospital. The goal i…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2 • Sponsor: Sheppard Pratt Health System • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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New drug shows promise for Long-Term bipolar depression control
Disease control ENROLLING_BY_INVITATIONThis study tests the long-term safety and effectiveness of azetukalner in 400 adults with bipolar I or II depression who already completed a previous study on the same drug. Participants will take the medication openly (everyone knows they are getting it) for an extended period. …
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE3 • Sponsor: Xenon Pharmaceuticals Inc. • Aim: Disease control
Last updated May 11, 2026 20:50 UTC
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Shock therapy showdown: MST takes on ECT for depression relief
Symptom relief OngoingThis study compares two types of brain stimulation—Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT)—in 100 adults with severe depression that hasn't improved with standard treatments. The goal is to see which therapy works better for lifting mood and which cause…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE2, PHASE3 • Sponsor: University of Sao Paulo • Aim: Symptom relief
Last updated May 22, 2026 14:01 UTC
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Light therapy shows promise for bipolar depression in night owls
Symptom relief OngoingThis study tests whether using a bright light box for six weeks can improve mood and sleep in people with bipolar depression who naturally feel more alert in the evening. About 70 adults aged 18-65 will either receive the light therapy or a placebo light. The goal is to see if th…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Chinese University of Hong Kong • Aim: Symptom relief
Last updated May 22, 2026 13:53 UTC
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Sweat away the blues: study tests exercise as bipolar depression treatment
Symptom relief TerminatedThis study looks at whether moderate-to-vigorous aerobic exercise can speed up recovery from bipolar depression and help prevent future depressive episodes. Fifty-four adults with bipolar disorder and current depression will be randomly assigned to either supervised aerobic exerc…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated May 22, 2026 13:49 UTC
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Brain scans reveal Lithium's secret workings in bipolar depression
Knowledge-focused OngoingThis study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 6 months in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…
Matched conditions: BIPOLAR DEPRESSION
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated May 26, 2026 04:17 UTC
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Brain scans reveal how gentle magnetic pulses affect bipolar depression in older adults
Knowledge-focused OngoingThis study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. About 40 participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects…
Matched conditions: BIPOLAR DEPRESSION
Phase: NA • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated May 22, 2026 13:52 UTC
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Brain scans aim to unlock antidepressant secrets of bipolar drug
Knowledge-focused TerminatedThis study planned to use brain imaging (PET scans) to see how cariprazine (Vraylar) affects dopamine D3 receptors in people with bipolar depression. The goal was to learn how the medication eases depression, not to test a new treatment. However, the study was withdrawn before an…
Matched conditions: BIPOLAR DEPRESSION
Phase: PHASE4 • Sponsor: New York State Psychiatric Institute • Aim: Knowledge-focused
Last updated May 19, 2026 11:48 UTC